Article
Cell Biology
Zhen Tang, Xinghui Wei, Tian Li, Wei Wang, Hao Wu, Hui Dong, Yichao Liu, Feilong Wei, Lei Shi, Xiaokang Li, Zheng Guo, Xin Xiao
Summary: The study elucidates the potential role of Sestrin2 in regulating the sensitivity of osteosarcoma to chemotherapy, demonstrating that Sestrin2 activates autophagy by inhibiting the mTOR pathway and decreases apoptosis via Bcl-2, ultimately slowing down tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Moein Ala
Summary: Sestrin2 acts as an antioxidant, metabolism regulator, and inhibitor of cancer development. However, it can also enhance cancer cell survival and chemoresistance, inhibit oncogenic signaling pathways, and decrease the cytotoxic activity of immune cells.
BIOMARKER RESEARCH
(2022)
Article
Cell Biology
Sue Young Oh, Namju Kang, Jung Yun Kang, Ki Woo Kim, Jong-Hoon Choi, Yu-Mi Yang, Dong Min Shin
Summary: This study revealed that Sestrin2 plays a crucial role in bone homeostasis and osteoclast differentiation by regulating NFATc1 and the TRAF6/p62 interaction in the RANKL-RANK-TRAF6 signaling pathway. The deletion of Sestrin2 led to a decrease in osteoclast differentiation and function, as well as reduced bone mass, suggesting its novel role in bone metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daewon Han, Haeil Kim, Soojin Kim, Qui Anh Le, Seung Yun Han, Jeongyun Bae, Hye Won Shin, Hyun-Goo Kang, Kyung Ho Han, Jongdae Shin, Hwan-Woo Park
Summary: Sestrin2 plays a crucial role in cholestatic liver injury, with its deficiency leading to heightened ER stress and severe liver damage. Additionally, Sestrin2 deficiency promotes cholestasis-induced hepatic pyroptosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Shang-Der Chen, Jenq-Lin Yang, Yi-Heng Hsieh, Tsu-Kung Lin, Yi-Chun Lin, A-Ching Chao, Ding- Yang
Summary: Alzheimer's disease is a common age-related neurodegenerative disease with complex pathogenic mechanisms and no effective treatment currently available. Sestrin2 may play a crucial role in the treatment of neurodegenerative diseases like AD, but limited research has been conducted on its potential benefits.
Article
Medical Laboratory Technology
Vahid Saeedi, Mona Nourbakhsh, Mitra Nourbakhsh, Ladan Haghighi, Leila Kamalzadeh, Samira Ezzati Mobasser, Maryam Razzaghy-Azar
Summary: Plasma levels of Sestrin2 were significantly lower in PCOS patients compared to healthy controls and showed potential as a novel biomarker for PCOS. However, there were no significant differences in plasma levels of beclin1 between the two groups, indicating the need for further research on its role in the pathophysiology of PCOS.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Oncology
Josef Gillson, Yomna S. Abd El-Aziz, Lionel Y. W. Leck, Patric J. Jansson, Nick Pavlakis, Jaswinder S. Samra, Anubhav Mittal, Sumit Sahni
Summary: This review discusses the importance of the autophagy pathway and tumor microenvironment in pancreatic cancer, as well as novel therapeutic strategies to inhibit autophagy. Pancreatic cancer is characterized by fast growth, invasiveness, and chemo-resistance, with low survival rates. The autophagy pathway plays a crucial role as a survival pathway in pancreatic cancer cells and promotes tumor progression and metastasis. Therefore, investigating therapeutic strategies targeting the autophagy pathway is crucial for overcoming chemo-resistance in pancreatic cancer.
Article
Biochemistry & Molecular Biology
Olga Fedorova, Alexandra Daks, Sergey Parfenyev, Oleg Shuvalov, Sofia Netsvetay, Julia Vasileva, Anastasia Gudovich, Vasilii Golotin, Oleg Semenov, Alexey Petukhov, Ekaterina Baiduik, Nurken Berdigaliyev, Eugene M. Tulchinsky, Nikolai A. Barlev
Summary: The text delves into the role of autophagy in cellular processes, exploring the relationship between autophagy and DNA damage, as well as the mechanisms through which tumor cells and breast cancer cells handle anticancer drugs and drug resistance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yi-Heng Hsieh, A-Ching Chao, Yi-Chun Lin, Shang-Der Chen, Ding- Yang
Summary: Senile plaques composed of neurotoxic amyloid-beta peptide are a pathological hallmark of Alzheimer's disease. Sestrin2, induced by various stressors, promotes autophagy and exerts antioxidative effects. The molecular mechanisms underlying A beta induction of sestrin2 involve the transcription factors p53 and NF-kappa B.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Na Qu, Junsheng Qu, Na Huang, Kexin Zhang, Tongtong Ye, Junfeng Shi, Bing Chen, Chengxia Kan, Jingwen Zhang, Fang Han, Ningning Hou, Xiaodong Sun, Ruiyan Pan
Summary: Calycosin inhibits the migration and invasion of papillary thyroid cancer cells by promoting apoptosis and autophagy through the Sestrin2/AMPK/mTOR pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Venturina Stagni, Alessandra Ferri, Claudia Cirotti, Daniela Barila
Summary: There is a strong interplay between autophagy and genomic stability, with recent evidence linking DNA Damage Response (DDR) and autophagy in influencing cell fate. ATM kinase plays a crucial role in balancing senescence and apoptosis in response to stimuli, and its aberrant deregulation is linked to the development of pathologies like cancer and neurodegeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Moussa Omorou, Yiwei Huang, Meng Gao, Chenxi Mu, Weijing Xu, Yuchun Han, Hui Xu
Summary: Forkhead box O3 (FOXO3) is a protein encoded by the FOXO3 gene expressed throughout the body and could play a crucial role in longevity and various pathologies. This study comprehensively reviews the expression of FOXO3 under ischemia and reperfusion (IR) conditions and its molecular mechanisms. The expression level of FOXO3 is tissue-specific, with increased expression in lung and intestinal epithelial cells after IR but downregulation in the kidney after IR and skeletal muscles following ischemia. FOXO3 expression in the brain, liver, and heart following IR can be both increased and decreased, contributing to ischemia and reperfusion injury. Controlling FOXO3 expression genetically or pharmacologically may help prevent or treat IR damage.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Juntae Kwon, Hyeongjwa Choi, Anna D. Ware, Bernadette Cecilia Morillo, Haiyang Wang, Kerrie B. Bouker, Xiongbin Lu, Todd Waldman, Cecil Han
Summary: Epithelial ovarian cancer is a lethal gynecologic malignancy, with USP13 gene amplification and overexpression being correlated with poor survival outcomes. In a mouse model, overexpression of USP13 accelerated ovarian tumorigenesis and led to decreased survival, enhanced peritoneal metastasis, and development of hemorrhagic ascites. Inhibition of USP13 decreased the viability of ovarian cancer cells and reduced tumorigenic and metastatic abilities. USP13 may be a potential therapeutic target for ovarian cancer.
Review
Cell Biology
Xinyue Wang, Xiao Tan, Jinping Zhang, Jiaping Wu, Hongjuan Shi
Summary: Ferroptosis, a newly discovered form of programmed cell death, is characterized by peroxidative damage to polyunsaturated-fatty-acid-containing phospholipids and is highly dependent on iron ions. It is closely associated with the pathogenesis of various diseases and is regulated by multiple signaling pathways, including the MAPK-AMPK pathway. This review summarizes the molecular mechanisms underlying the regulation of ferroptosis by the MAPK-AMPK pathway and discusses the potential therapeutic strategies targeting this pathway.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, Research & Experimental
Hui Gong, Xing Lyu, Yang Liu, Naling Peng, Shengyu Tan, Lini Dong, Xiangyu Zhang
Summary: Eupatilin alleviates pulmonary fibrosis through the Sestrin2/PI3K/Akt/mTOR-dependent autophagy pathway, reducing the expression of fibrotic markers. This study provides a new insight and potential drug target for the treatment of IPF.
