Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling

(2012) Isabel F. Fernández et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage

(2012) Marta Sanz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2

(2012) Marta Vázquez-Cedeira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of VRK1 as a new player in the control of biological processes required for cell division

(2011) Alberto Valbuena et al.   CELLULAR SIGNALLING

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity

(2011) Joon Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macro Histone H2A1.2 (MacroH2A1) Protein Suppresses Mitotic Kinase VRK1 during Interphase

(2011) Wanil Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications

(2011) Marta Sanz-García et al.   Journal of Proteomics

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2

(2011) Marta Vázquez-Cedeira et al.   PLoS One

Mitochondrial HEP27 Is a c-Myb Target Gene That Inhibits Mdm2 and Stabilizes p53

(2010) C. Deisenroth et al.   MOLECULAR AND CELLULAR BIOLOGY

VRK2 Inhibits Mitogen-Activated Protein Kinase Signaling and Inversely Correlates with ErbB2 in Human Breast Cancer

(2010) I. F. Fernandez et al.   MOLECULAR AND CELLULAR BIOLOGY

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions

(2009) M Reis-Sobreiro et al.   ONCOGENE

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

(2009) Eric D. Scheeff et al.   STRUCTURE

VRK1 phosphorylates CREB and mediates CCND1 expression

(2008) T.-H. Kang et al.   JOURNAL OF CELL SCIENCE

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities

(2008) Marta Sanz-García et al.   MOLECULAR & CELLULAR PROTEOMICS

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

(2008) I. Lopez-Sanchez et al.   MOLECULAR AND CELLULAR BIOLOGY

Cytochrome c: functions beyond respiration

(2008) Yong-Ling P. Ow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expansion and evolution of cell death programmes

(2008) Alexei Degterev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

(2008) Alberto Valbuena et al.   PLoS One

Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein

(2008) Sandra Blanco et al.   PLoS One

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY