VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling

Roles of VRK1 as a new player in the control of biological processes required for cell division

(2011) Alberto Valbuena et al.   CELLULAR SIGNALLING

Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress

(2011) Abhisek Mukherjee et al.   CURRENT OPINION IN CELL BIOLOGY

Compartmentalization of the MAPK scaffold protein KSR1 modulates synaptic plasticity in hippocampal neurons

(2011) Frédéric Canal et al.   FASEB JOURNAL

Valosin-Containing Protein Gene Mutations: Cellular Phenotypes Relevant to Neurodegeneration

(2011) Karen S. Poksay et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway

(2011) Alberto Valbuena et al.   PLoS One

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2

(2011) Marta Vázquez-Cedeira et al.   PLoS One

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

VRK2 Inhibits Mitogen-Activated Protein Kinase Signaling and Inversely Correlates with ErbB2 in Human Breast Cancer

(2010) I. F. Fernandez et al.   MOLECULAR AND CELLULAR BIOLOGY

A Ceramide-binding C1 Domain Mediates Kinase Suppressor of Ras Membrane Translocation

(2009) Xianglei Yin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

(2009) S.-Y. Shin et al.   JOURNAL OF CELL SCIENCE

C-Raf Inhibits MAPK Activation and Transformation by B-RafV600E

(2009) Florian A. Karreth et al.   MOLECULAR CELL

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Cell fate decisions are specified by the dynamic ERK interactome

(2009) Alex von Kriegsheim et al.   NATURE CELL BIOLOGY

Signaling dynamics of the KSR1 scaffold complex

(2009) M. M. McKay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

IMP Modulates KSR1-dependent Multivalent Complex Formation to Specify ERK1/2 Pathway Activation and Response Thresholds

(2008) Chiyuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Functional Interaction of 14-3-3 Proteins with the ERK1/2 Scaffold KSR1 Occurs in an Isoform-specific Manner

(2008) Lucas R. Jagemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

(2008) Alberto Valbuena et al.   PLoS One

Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein

(2008) Sandra Blanco et al.   PLoS One

VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues

(2007) Tae-Hong Kang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH