Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2

VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling

(2012) Isabel F. Fernández et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

COX2 overexpression is a prognostic marker for Stage III breast cancer

(2011) Hee Sung Kim et al.   BREAST CANCER RESEARCH AND TREATMENT

Exposure to cyclooxygenase-2 inhibitors and risk of cancer: nested case–control studies

(2011) Y Vinogradova et al.   BRITISH JOURNAL OF CANCER

Roles of VRK1 as a new player in the control of biological processes required for cell division

(2011) Alberto Valbuena et al.   CELLULAR SIGNALLING

Cyclooxygenase-2 and Akt mediate multiple growth-factor-induced epithelial-mesenchymal transition in human hepatocellular carcinoma

(2011) Olorunseun O Ogunwobi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway

(2011) Alberto Valbuena et al.   PLoS One

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2

(2011) Marta Vázquez-Cedeira et al.   PLoS One

VRK2 Inhibits Mitogen-Activated Protein Kinase Signaling and Inversely Correlates with ErbB2 in Human Breast Cancer

(2010) I. F. Fernandez et al.   MOLECULAR AND CELLULAR BIOLOGY

NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma

(2009) R J Flockhart et al.   BRITISH JOURNAL OF CANCER

Mechanoregulation of Proliferation

(2009) X. Jiang et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrin ( 6 4) Signals Through Src to Increase Expression of S100A4, a Metastasis-Promoting Factor: Implications for Cancer Cell Invasion

(2009) T. H. Kim et al.   MOLECULAR CANCER RESEARCH

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

(2009) Eric D. Scheeff et al.   STRUCTURE

Targeted Deletion of the Calcineurin Inhibitor DSCR1 Suppresses Tumor Growth

(2008) Sandra Ryeom et al.   CANCER CELL

Cyclooxygenase-2 Inhibition Inhibits c-Met Kinase Activity and Wnt Activity in Colon Cancer

(2008) J. B. Tuynman et al.   CANCER RESEARCH

VRK1 phosphorylates CREB and mediates CCND1 expression

(2008) T.-H. Kang et al.   JOURNAL OF CELL SCIENCE

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

(2008) Alberto Valbuena et al.   PLoS One

Modulation of Interleukin-1 Transcriptional Response by the Interaction between VRK2 and the JIP1 Scaffold Protein

(2008) Sandra Blanco et al.   PLoS One

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53

(2008) Alberto Valbuena et al.   PLoS One