Article
Cell Biology
Jiamin Deng, Shangqi Wang, Nan Li, Xiaoyan Chen, Biying Wang, Han Liu, Lei Zhu, Wei Cong, Jing Xiao, Chao Liu
Summary: The study demonstrates the significant role of BMP signaling in soft palate development, affecting cell proliferation, survival, soft palate shelf size, and muscle development. It is suggested that the BMP-Shh-Gli1 network plays a similar role in soft palate development as in hard palate development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Justin T. Avery, Ruowen Zhang, Rebecca J. Boohaker
Summary: GLI1, a transcriptional effector in the Hedgehog signaling pathway, is tightly regulated during normal tissue development but aberrant activation in cancer can promote hallmarks such as proliferation, metastasis, and chemoresistance. Its oncogenic activities mainly involve regulating cell cycle, DNA replication, and DNA damage repair processes. Understanding the mechanisms of GLI1 dysregulation can provide prognostic and diagnostic biomarkers for targeted therapy in cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Saki Fujii, Hiroaki Takebe, Toshihide Mizoguchi, Hiroaki Nakamura, Tsuyoshi Shimo, Akihiro Hosoya
Summary: During socket healing after tooth extraction, Gli1+-PDL cells differentiate into osteoblasts that form the bone matrix in the tooth socket, and this differentiation may be regulated by bone morphogenetic protein (BMP) signaling. The absence of Gli1+-PDL cells significantly reduces the amount of newly formed bone matrix in the tooth socket. These findings provide insights into the cellular mechanisms of tooth socket healing and suggest potential targets for promoting bone regeneration in dental procedures.
Article
Biology
Sumit Siddharth, Sheetal Parida, Nethaji Muniraj, Shawn Hercules, David Lim, Arumugam Nagalingam, Chenguang Wang, Balazs Gyorffy, Juliet M. Daniel, Dipali Sharma
Summary: African American women with TNBC have inherently aggressive cells with enriched GLI1 and Notch1 pathways compared to White American women. Inhibition of these pathways improves chemotherapy efficacy in AA-TNBC cells, suggesting a potential triple-combination therapy for improving outcomes in AA-TNBC.
Article
Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Article
Oncology
Taiji Hamada, Michiyo Higashi, Seiya Yokoyama, Toshiaki Akahane, Masanori Hisaoka, Hirotsugu Noguchi, Tatsuhiko Furukawa, Akihide Tanimoto
Summary: This study elucidates the structure and function of the MALAT1::GLI1 fusion gene. The researchers found that MALAT1 exhibits transcriptional activity and induces expression of GLI1 from the fusion gene. Truncated GLI1, lacking certain binding sites, upregulates mRNA expression of GLI1 target genes in the hedgehog signaling pathway. These findings will contribute to future research on MALAT1 and its fusion gene partners.
Article
Pharmacology & Pharmacy
Minyu Wang, Wanying Huang
Summary: This study found that FOXS1 activates the Hedgehog (Hh) signaling pathway by blocking the ubiquitination of Gli1, thereby promoting the growth and metastasis of prostate cancer cells. High levels of FOXS1 were associated with worse tumor stage and shorter survival in prostate cancer patients.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Food Science & Technology
Selda Gezginci-Oktayoglu, Merve Ercin, Serap Sancar, Ertan Celik, Meral Koyuturk, Sema Bolkent, Sehnaz Bolkent
Summary: The study showed that aspartame increases cancer stem cell population and aggressiveness of pancreatic cancer cells, while glucose does not have the same effect. Glucose exposure can induce differentiation through specific genes, while aspartame activates certain signaling pathways affecting cell proliferation.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Virology
Maria Dolci, Lucia Signorini, Wafa Toumi, Giuseppe Basile, Sarah D'Alessandro, Pasquale Ferrante, Serena Delbue
Summary: This study found the presence of HPyVs in colon cancer patients, with a higher positivity rate in tumor tissues, indicating a potentially significant role of MCPyV in colon tumorigenesis.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Heping Cao, Kandan Sethumadhavan, Xiaoyu Wu, Xiaochun Zeng, Lin Zhang
Summary: This study investigated the effects of cottonseed extracts on cell viability and gene expression in human colon cancer cells. The results showed that cottonseed extracts had minor effects on cell viability, but glandless seed kernel extract significantly reduced mRNA levels of many genes involved in glucose transport, lipid biosynthesis, and inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Qiong Wu, Jue Wei, Chen Zhao, Shihao Xiang, Min Shi, Yugang Wang
Summary: In this study, it was discovered that the long non-coding RNA EPIC1 binds to the MYC protein and its expression is elevated in human colon cancer cells. Silencing Lnc-EPIC1 inhibited cancer cell growth, proliferation, migration, and invasion, while overexpression of Lnc-EPIC1 augmented these cellular functions. The results suggest that Lnc-EPIC1 plays an important role in the progression of human colon cancer.
Article
Oncology
Antonia M. Stehr, Guangxia Wang, Richard Demmler, Marc P. Stemmler, Julia Krug, Philipp Tripal, Benjamin Schmid, Carol Geppert, Arndt Hartmann, Luis E. Munoz, Janina Schoen, Simon Voelkl, Susanne Merkel, Christoph Becker, Georg Schett, Robert Gruetzmann, Elisabeth Naschberger, Martin Herrmann, Michael Stuerzl
Summary: Neutrophil extracellular traps (NETs), released by neutrophils, have been found in colorectal cancer (CRC) tissues and are associated with disease progression. This study used high-resolution microscopy to detect citrullinated NETs in colon cancer tissues and found that citrullinated NETs were significantly associated with high tumour grades and lymph node metastasis. In vitro experiments also showed that purified NETs induced filopodia formation and cell motility in CRC cell lines, indicating their potential contribution to CRC metastasis.
JOURNAL OF PATHOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Arwa Althomali, Maha H. Daghestani, Fatimah Basil Almukaynizi, Sabah Ahmed Al-Zahrani, Manal A. Awad, Nada M. Merghani, Wadha Bukhari, Eiman M. Ibrahim, Sherifah M. Alzahrani, Nouf Altowair, Afaf S. AL-Ghamdi, Asma M. AlQahtani, Rasha Ramadan, Ramesa Shafi Bhat
Summary: By using Moringa oleifera leaves as reducing and stabilizing agents, this study synthesized green-synthesized AgNPs which exhibited significant cytotoxicity against cancer cells. Compared with the M. oleifera leaf extract, the synthesized nanoparticles showed better inhibitory effects on colon cancer cell growth and regulated the expression levels of multiple genes.
GREEN PROCESSING AND SYNTHESIS
(2022)
Article
Plant Sciences
Jing Chen, Da Ma, Cuicui Zeng, Lorenzo V. White, Huanqing Zhang, Yinglai Teng, Ping Lan
Summary: The steroidal alkaloid solasodine has been found to directly suppress Hh/Gli1 signaling, inhibiting the proliferation and self-renewal ability of cancer stem-like cells (CSCs). This compound may serve as a novel anticancer candidate targeting CSCs.
Article
Plant Sciences
Xiang Zhou, Weiming Wang, Zhaofeng Li, Lin Chen, Chunmei Wen, Qingqing Ruan, Zheng Xu, Rongdiao Liu, Jinzhong Xu, Yongheng Bai, Jie Deng
Summary: This study found that RA inhibited the nuclear translocation of Gli1 and facilitated Gli1 degradation via the proteasome pathway, reducing the malignancy of PDAC cells. Additionally, RA suppressed PDAC cell migration and invasion by regulating the expression of key proteins. These findings highlight the potential of RA as a therapeutic agent for PDAC.
Article
Cell Biology
Grigori Singovski, Carolina Bernal, Monika Kuciak, Irene Siegl-Cachedenier, Arwen Conod, Ariel Ruiz i Altaba
JOURNAL OF MOLECULAR CELL BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Chandan Seth, Ariel Ruiz I. Altaba
Article
Multidisciplinary Sciences
Chandan Seth, Christophe Mas, Arwen Conod, Jens Mueller, Karsten Siems, Monika Kuciak, Isabel Borges, Ariel Ruiz I. Altaba
Review
Pharmacology & Pharmacy
Christophe Mas, Ariel Ruiz I Altaba
BIOCHEMICAL PHARMACOLOGY
(2010)
Article
Medicine, Research & Experimental
Frederic Varnat, Irene Siegl-Cachedenier, Monica Malerba, Pascal Geruaz, Ariel Ruiz i Altaba
EMBO MOLECULAR MEDICINE
(2010)
Article
Medicine, Research & Experimental
Arnaud Duquet, Alice Melotti, Sonakshi Mishra, Monica Malerba, Chandan Seth, Arwen Conod, Ariel Ruiz i Altaba
EMBO MOLECULAR MEDICINE
(2014)
Article
Medicine, Research & Experimental
Alice Melotti, Christophe Mas, Monika Kuciak, Aiala Lorente-Trigos, Isabel Borges, Ariel Ruiz i Altaba
EMBO MOLECULAR MEDICINE
(2014)
Article
Developmental Biology
Frederic Varnat, Giovanna Zacchetti, Ariel Ruiz i Altaba
MECHANISMS OF DEVELOPMENT
(2010)
Review
Biology
M. Verbeni, O. Sanchez, E. Mollica, I. Siegl-Cachedenier, A. Carleton, I. Guerrero, A. Ruiz i Altaba, J. Soler
PHYSICS OF LIFE REVIEWS
(2013)
Review
Cell Biology
Fritz Aberger, Ariel Ruiz i Altaba
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2014)
Review
Cell Biology
Barbara Stecca, Ariel Ruiz i Altaba
JOURNAL OF MOLECULAR CELL BIOLOGY
(2010)
Review
Biochemistry & Molecular Biology
Patrycja Nowak-Sliwinska, Leonardo Scapozza, Ariel Ruiz i Altaba
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2019)
Article
Cell Biology
Carolina Bernal, Marianna Silvano, Yann Tapponnier, Santosh Anand, Cecilia Angulo, Ariel Ruiz i Altaba
Article
Multidisciplinary Sciences
Monika Kuciak, Christophe Mas, Isabel Borges, Pilar Sanchez-Gomez, Ariel Ruiz i Altaba
SCIENTIFIC REPORTS
(2019)