Towards bacterial adhesion-based therapeutics and detection methods

CH−π “T-Shape” Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA

(2013) Rameshwar U. Kadam et al.   ACS Chemical Biology

Discovery of Two Classes of Potent Glycomimetic Inhibitors of Pseudomonas aeruginosa LecB with Distinct Binding Modes

(2013) Dirk Hauck et al.   ACS Chemical Biology

Bridging lectin binding sites by multivalent carbohydrates

(2013) Valentin Wittmann et al.   CHEMICAL SOCIETY REVIEWS

Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors

(2013) Jean-Louis Reymond et al.   CHEMICAL SOCIETY REVIEWS

Optimizing Divalent Inhibitors ofPseudomonas aeruginosaLectin LecA by Using A Rigid Spacer

(2013) Francesca Pertici et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Multivalent Carbohydrate-Centered Glycoclusters as Nanomolar Ligands of the Bacterial Lectin LecA fromPseudomonas aeruginosa

(2013) Marina L. Gening et al.   CHEMISTRY-A EUROPEAN JOURNAL

Heptyl α-D-Mannosides Grafted on a β-Cyclodextrin Core To Interfere withEscherichia coliAdhesion: An In Vivo Multivalent Effect

(2013) Julie Bouckaert et al.   CHEMISTRY-A EUROPEAN JOURNAL

Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn’s Disease Patients

(2013) Sami Brument et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycan-functionalized diamond nanoparticles as potent E. coli anti-adhesives

(2013) Alexandre Barras et al.   Nanoscale

Aromatic thioglycoside inhibitors against the virulence factor LecA from Pseudomonas aeruginosa

(2013) Jacques Rodrigue et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

(2012) Francesca Pertici et al.   CHEMICAL COMMUNICATIONS

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Saccharide-Modified Nanodiamond Conjugates for the Efficient Detection and Removal of Pathogenic Bacteria

(2012) Mirja Hartmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rational Design and Synthesis of Optimized Glycoclusters for Multivalent Lectin-Carbohydrate Interactions: Influence of the Linker Arm

(2012) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

FimH Antagonists: Structure-Activity and Structure-Property Relationships for Biphenyl α-D-Mannopyranosides

(2012) Lijuan Pang et al.   ChemMedChem

Inhibition of bacterial adhesion to live human cells: Activity and cytotoxicity of synthetic mannosides

(2012) Mirja Hartmann et al.   FEBS LETTERS

Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success

(2012) Xiaohua Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides

(2012) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms

(2011) Rameshwar U. Kadam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Squaric Acid Monoamide Mannosides as Ligands for the Bacterial Lectin FimH: Covalent Inhibition or Not?

(2011) Carsten Grabosch et al.   CHEMBIOCHEM

Clustering of Escherichia coli Type-1 Fimbrial Adhesins by Using Multimeric Heptyl α-D-Mannoside Probes with a Carbohydrate Core

(2011) Mehdi Almant et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Bacterial Lectin FimH, a Target for Drug Discovery - Carbohydrate Inhibitors of Type 1 Fimbriae-Mediated Bacterial Adhesion

(2011) Mirja Hartmann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Identification of a Novel Streptococcal Adhesin P (SadP) Protein Recognizing Galactosyl-α1–4-galactose-containing Glycoconjugates

(2011) Annika Kouki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

(2011) C. K. Cusumano et al.   Science Translational Medicine

Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

(2011) Emma M. V. Johansson et al.   MedChemComm

Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity

(2011) Ondřej Šulák et al.   PLoS Pathogens

Bishydrazide Glycoconjugates for Lectin Recognition and Capture of Bacterial Pathogens

(2010) Avijit Kumar Adak et al.   BIOCONJUGATE CHEMISTRY

Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray

(2010) Núria Parera Pera et al.   CHEMBIOCHEM

The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives

(2010) Maxime Durka et al.   CHEMICAL COMMUNICATIONS

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

(2010) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

(2010) Tobias Klein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Detection of pathogenic Streptococcus suis bacteria using magnetic glycoparticles

(2010) Núria Parera Pera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Role of LecA and LecB Lectins in Pseudomonas aeruginosa-Induced Lung Injury and Effect of Carbohydrate Ligands

(2009) C. Chemani et al.   INFECTION AND IMMUNITY

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Biotinylated Bi- and Tetra-antennary Glycoconjugates forEscherichia coliDetection

(2008) Duane M. Hatch et al.   CHEMBIOCHEM

Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB

(2008) Emma M.V. Johansson et al.   CHEMISTRY & BIOLOGY

Synthesis of multivalent Streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and ‘click’ conjugation

(2008) Hilbert M. Branderhorst et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bacterial detection using carbohydrate-functionalised CdS quantum dots: a model study exploiting E. coli recognition of mannosides

(2008) Balaram Mukhopadhyay et al.   TETRAHEDRON LETTERS