Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and in Vitro Antimalarial Testing of Neocryptolepines: SAR Study for Improved Activity by Introduction and Modifications of Side Chains at C2 and C11 on Indolo[2,3-b]quinolines

(2013) Zhen-Wu Mei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase–Lens Epithelium-Derived Growth Factor/p75 (IN–LEDGF/p75) Interaction

(2013) Erik Serrao et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

(2012) Danling Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure–activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription

(2012) Bingbing X. Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors

(2012) Adrian Wai-Hing Cheung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Updates in the treatment of basal/triple-negative breast cancer

(2012) Mythili Shastry et al.   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Chemical and Biological Properties of Frequent Screening Hits

(2012) Jianwei Che et al.   Journal of Chemical Information and Modeling

Design, Synthesis, and Biological Evaluation of Conformationally Constrained Analogues of Naphthol AS-E as Inhibitors of CREB-Mediated Gene Transcription

(2012) Min Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy

(2012) Jonathan A. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Aided Design of Novel Inhibitors of HIV Protease Based on a Benzodiazepine Scaffold

(2012) Jiří Schimer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fully Functionalized Small-Molecule Probes for Integrated Phenotypic Screening and Target Identification

(2012) Justin S. Cisar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting CREB for Cancer Therapy: Friend or Foe

(2010) X. Xiao et al.   CURRENT CANCER DRUG TARGETS

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protease-activated receptor 1 antagonists prevent platelet aggregation and adhesion without affecting thrombin time

(2010) Florence Nadal-Wollbold et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Discovery of a Small-Molecule Inhibitor of the KIX–KID Interaction

(2009) Bingbing X. Li et al.   CHEMBIOCHEM

Triple negative breast cancer: current understanding of biology and treatment options

(2009) Soonmo Peter Kang et al.   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY