Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

Testing Physical Models of Passive Membrane Permeation

(2012) Siegfried S. F. Leung et al.   Journal of Chemical Information and Modeling

Predicting and Improving the Membrane Permeability of Peptidic Small Molecules

(2012) Salma B. Rafi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified

(2012) Johannes G. Beck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a new permeability assay using low‐efflux MDCKII cells

(2011) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

(2008) Eric Biron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High Throughput ADME Screening: Practical Considerations, Impact on the Portfolio and Enabler of In Silico ADME Models

(2008) Cornelis Hop et al.   CURRENT DRUG METABOLISM