期刊
MEDCHEMCOMM
卷 3, 期 10, 页码 1282-1289出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2md20203d
关键词
-
资金
- NIH [R01-GM086602]
A series of cyclic peptides were designed and prepared to investigate the physicochemical properties that affect oral bioavailabilty of this chemotype in rats. In particular, the ionization state of the peptide was examined by the incorporation of naturally occurring amino acid residues that are charged in differing regions of the gut. In addition, data was generated in a variety of in vitro assays and the usefulness of this data in predicting the subsequent oral bioavailability observed in the rat is discussed.
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