The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

Extraction of tacit knowledge from large ADME data sets via pairwise analysis

(2011) Christopher E. Keefer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Deep understanding of structure–solubility relationship for a diverse set of organic compounds using matched molecular pairs

(2011) Liying Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

(2011) Nicholas A. Meanwell   CHEMICAL RESEARCH IN TOXICOLOGY

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity

(2011) Robert J. Young et al.   DRUG DISCOVERY TODAY

Matched Molecular Pairs as a Medicinal Chemistry Tool

(2011) Ed Griffen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxadiazoles in Medicinal Chemistry

(2011) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

The influence of the 'organizational factor' on compound quality in drug discovery

(2011) Paul D. Leeson et al.   NATURE REVIEWS DRUG DISCOVERY

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Are pyridazines privileged structures?

(2011) Camille G. Wermuth   MedChemComm

Molecular obesity, potency and other addictions in drug discovery

(2011) Michael M. Hann   MedChemComm

The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Impact of ion class and time on oral drug molecular properties

(2010) Paul D. Leeson et al.   MedChemComm

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Straightforward Recursive Partitioning Model for Discarding Insoluble Compounds in the Drug Discovery Process

(2008) Claudia Lamanna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY