The MEP pathway and the development of inhibitors as potential anti-infective agents

Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

(2012) Qinglin Du et al.   International Journal of Biological Sciences

Structural and functional studies of mycobacterial IspD enzymes

(2011) Christofer Björkelid et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding

(2011) Matthias C. Witschel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis

(2011) Mounir Andaloussi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Emerging trends in metalloprotein inhibition

(2011) Matthieu Rouffet et al.   DALTON TRANSACTIONS

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance inToxoplasma gondii

(2011) Sethu C. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr)

(2011) Christoph T. Behrendt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyridine Inhibitor Binding to the 4Fe-4S ProteinA. aeolicusIspH (LytB): A HYSCORE Investigation

(2011) Weixue Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY

Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

(2010) Julie G. Geist et al.   ChemMedChem

Structure of theE-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (GcpE) fromThermus thermophilus

(2010) Ingo Rekittke et al.   FEBS LETTERS

The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae

(2010) Yukiko Matsue et al.   JOURNAL OF ANTIBIOTICS

The Nonmevalonate Pathway of Isoprenoid Biosynthesis in Mycobacterium tuberculosis Is Essential and Transcriptionally Regulated by Dxs

(2010) A. C. Brown et al.   JOURNAL OF BACTERIOLOGY

Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe–4S] Cluster Protein IspG

(2010) Matthias Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of the Fe4S4-Cluster-Containing Protein IspH (LytB): Electron Paramagnetic Resonance, Metallacycles, and Mechanisms

(2010) Ke Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)

(2010) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes

(2010) Lisheng Deng et al.   ACS Medicinal Chemistry Letters

Structure of Active IspH Enzyme fromEscherichia coliProvides Mechanistic Insights into Substrate Reduction

(2009) Tobias Gräwert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene

(2009) Audrey R. Odom et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Probing the reaction mechanism of IspH protein by x-ray structure analysis

(2009) T. Grawert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure–activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase

(2008) Jialin Mao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake

(2008) Amanda C Brown et al.   BMC MICROBIOLOGY

The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets

(2008) Anna K. H. Hirsch et al.   CHIMIA

Structure of (E)-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

(2008) Ingo Rekittke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors of the kinase IspE: structure–activity relationships and co-crystal structure analysis

(2008) Anna K. H. Hirsch et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The plastidial MEP pathway: unified nomenclature and resources

(2008) M PHILLIPS et al.   TRENDS IN PLANT SCIENCE

Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis

(2007) Christine M. Crane et al.   ChemMedChem