Carba-LNA modified siRNAs targeting HIV-1 TAR region downregulate HIV-1 replication successfully with enhanced potency

Allele-Selective Inhibition of MutantHuntingtinExpression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat

(2010) Keith T. Gagnon et al.   BIOCHEMISTRY

Why Carba-LNA-Modified Oligonucleotides Show Considerably Improved 3′-Exonuclease Stability Compared to That of the LNA Modified or the Native Counterparts: A Michaelis−Menten Kinetic Analysis

(2010) Chuanzheng Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides

(2009) Koji Nagahama et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Smart conferring of nuclease resistance to DNA by 3′-end protection using 2′,4′-bridged nucleoside-5′-triphosphates

(2009) Masayasu Kuwahara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Conformationally Locked Carba-LNAs through Intramolecular Free-Radical Addition to C═N. Electrostatic and Steric Implication of the Carba-LNA Substituents in the Modified Oligos for Nuclease and Thermodynamic Stabilities

(2009) Jianfeng Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1

(2009) M. J. Dapp et al.   JOURNAL OF VIROLOGY

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

HIV Evades RNA Interference Directed at TAR by an Indirect Compensatory Mechanism

(2008) Joshua N. Leonard et al.   Cell Host & Microbe

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY

Transgenic Overexpression of Hdac3 in the Heart Produces Increased Postnatal Cardiac Myocyte Proliferation but Does Not Induce Hypertrophy

(2008) Chinmay M. Trivedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cPLA2phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells

(2008) Zoran Pavicevic et al.   JOURNAL OF LIPID RESEARCH

Synthesis of 6′-Branched Locked Nucleic Acid by a Radical TEMPO-Scavanged Stereoselective Mercury Cyclization

(2008) Gerald Enderlin et al.   JOURNAL OF ORGANIC CHEMISTRY

Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′,4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties

(2008) Chuanzheng Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, Synthesis, and Properties of 2‘,4‘-BNANC:  A Bridged Nucleic Acid Analogue

(2008) S. M. Abdur Rahman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the guide-strand-containing argonaute silencing complex

(2008) Yanli Wang et al.   NATURE

Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex

(2008) H. Van Melckebeke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA