Zwitterlation mitigates protein bioactivity loss in vitro over PEGylation

Simple Protein Modification Using Zwitterionic Polymer to Mitigate the Bioactivity Loss of Conjugated Insulin

(2017) Jinbing Xie et al.   Advanced Healthcare Materials

Inhibition of protein aggregation by zwitterionic polymer-based core-shell nanogels

(2017) Robin Rajan et al.   Scientific Reports

Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

(2016) Qi Yang et al.   ANALYTICAL CHEMISTRY

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Zwitterionic polymer-protein conjugates reduce polymer-specific antibody response

(2016) Sijun Liu et al.   Nano Today

Zwitterionic cryogels for sustained release of proteins

(2016) Gulsu Sener et al.   RSC Advances

Probing the Surface Hydration of Nonfouling Zwitterionic and PEG Materials in Contact with Proteins

(2015) Chuan Leng et al.   ACS Applied Materials & Interfaces

Conjugation of PolyPEG to Interferon Alpha Extends Serum Half-Life while Maintaining Low Viscosity of the Conjugate

(2015) B. Podobnik et al.   BIOCONJUGATE CHEMISTRY

Neutron reflectometry from poly (ethylene-glycol) brushes binding anti-PEG antibodies: Evidence of ternary adsorption

(2015) Emanuel Schneck et al.   BIOMATERIALS

Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation

(2015) Somnath Bhattacharjee et al.   CHEMBIOCHEM

Protein–polymer conjugation—moving beyond PEGylation

(2015) Yizhi Qi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity

(2015) Peng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Understanding and Design of Zwitterionic Materials

(2014) Qing Shao et al.   ADVANCED MATERIALS

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zwitterionic Coatings: Zwitterionic-Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System (Small 13/2014)

(2014) Karina Pombo García et al.   Small

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

(2014) Michael S Hershfield et al.   ARTHRITIS RESEARCH & THERAPY

Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout

(2014) Peter E Lipsky et al.   ARTHRITIS RESEARCH & THERAPY

Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins

(2013) Mark G.P. Saifer et al.   MOLECULAR IMMUNOLOGY

Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

(2013) Lei Zhang et al.   NATURE BIOTECHNOLOGY

Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates

(2012) Merry R. Sherman et al.   BIOCONJUGATE CHEMISTRY

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon

(2012) Kouichi Shiraishi et al.   JOURNAL OF CONTROLLED RELEASE

Site-Selective Glycosylation of Hemoglobin with Variable Molecular Weight Oligosaccharides: Potential Alternative to PEGylation

(2012) Thomas J. Styslinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Pharmacology and Toxicology Evaluation of Polyethylene Glycol-Conjugated Interferon  -1a

(2011) X. Hu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity

(2011) Andrew J. Keefe et al.   Nature Chemistry

Surface hydration: Principles and applications toward low-fouling/nonfouling biomaterials

(2010) Shenfu Chen et al.   POLYMER

Conformational recovery and preservation of protein nature from heat-induced denaturation by water-soluble phospholipid polymer conjugation

(2009) Ji-Hun Seo et al.   BIOMATERIALS

Poly(2-methacryloyloxyethyl phosphorylcholine) for Protein Conjugation

(2008) Andrew Lewis et al.   BIOCONJUGATE CHEMISTRY

The Impact of PEGylation on Biological Therapies

(2008) Francesco M Veronese et al.   BIODRUGS

The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics

(2008) C.Simone Fishburn   JOURNAL OF PHARMACEUTICAL SCIENCES

Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes

(2007) Tatsuhiro Ishida et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY