Negative regulation of NF-κB and its involvement in rheumatoid arthritis

A20 suppresses inflammatory responses and bone destruction in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis

(2010) Young-Sool Hah et al.   ARTHRITIS AND RHEUMATISM

SIGIRR/TIR-8 is an inhibitor of toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis

(2010) Stefan K. Drexler et al.   ARTHRITIS AND RHEUMATISM

Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation

(2010) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

(2010) Y. Chu et al.   BLOOD

Expanding role of ubiquitination in NF-κB signaling

(2010) Siqi Liu et al.   CELL RESEARCH

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

(2010) Lu Wang et al.   IMMUNITY

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

(2010) Rita M. Tavares et al.   IMMUNITY

A polymorphism in the 3’-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility

(2010) Anthoula Chatzikyriakidou et al.   JOINT BONE SPINE

Allosteric Regulation of the Ubiquitin:NIK and Ubiquitin:TRAF3 E3 Ligases by the Lymphotoxin-β Receptor

(2010) Hideki Sanjo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential TRAF3 Utilization by a Variant Human CD40 Receptor with Enhanced Signaling

(2010) A. L. Peters et al.   JOURNAL OF IMMUNOLOGY

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Negative Feedback in Noncanonical NF- B Signaling Modulates NIK Stability Through IKK -Mediated Phosphorylation

(2010) B. Razani et al.   Science Signaling

Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis

(2010) Koichi Murata et al.   ARTHRITIS RESEARCH & THERAPY

Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis

(2010) Jingyi Li et al.   ARTHRITIS RESEARCH & THERAPY

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2009) Yuji Nakamachi et al.   ARTHRITIS AND RHEUMATISM

TRAF1polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians

(2009) Tae-Un Han et al.   ARTHRITIS AND RHEUMATISM

ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling

(2009) Lynn Verstrepen et al.   BIOCHEMICAL PHARMACOLOGY

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis

(2009) Valerio Fulci et al.   HUMAN IMMUNOLOGY

Gene discovery in rheumatoid arthritis highlights the CD40/NF-ĸB signaling pathway in disease pathogenesis

(2009) Lindsey A. Criswell   IMMUNOLOGICAL REVIEWS

A20 Negatively Regulates T Cell Receptor Signaling to NF- B by Cleaving Malt1 Ubiquitin Chains

(2009) M. Duwel et al.   JOURNAL OF IMMUNOLOGY

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

Autoregulatory feedback loops terminating the NF-κB response

(2009) Florian Renner et al.   TRENDS IN BIOCHEMICAL SCIENCES

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

(2009) Lars Vereecke et al.   TRENDS IN IMMUNOLOGY

Toll-like receptors and NOD-like receptors in rheumatic diseases

(2009) William J McCormack et al.   ARTHRITIS RESEARCH & THERAPY

The role of Toll-like receptors in rheumatoid arthritis

(2009) Qi-Quan Huang et al.   Current Rheumatology Reports

Expression of microRNA-146 in rheumatoid arthritis synovial tissue

(2008) Tomoyuki Nakasa et al.   ARTHRITIS AND RHEUMATISM

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-κB activation

(2008) Hidekatsu Iha et al.   EMBO JOURNAL

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

(2008) Osamu Hitotsumatsu et al.   IMMUNITY

Targeting NF-κB: A Promising Molecular Therapy in Inflammatory Arthritis

(2008) Jorge A. Roman-Blas et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice

(2008) Wei Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

(2008) Shigeru Oshima et al.   NATURE

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins

(2008) S Wagner et al.   ONCOGENE

Biomarkers in osteoarthritis

(2008) Frances MK Williams et al.   ARTHRITIS RESEARCH & THERAPY

The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis

(2008) Keith D Brown et al.   ARTHRITIS RESEARCH & THERAPY

A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2

(2008) Monica Chang et al.   PLoS Genetics