Allosteric Regulation of the Ubiquitin:NIK and Ubiquitin:TRAF3 E3 Ligases by the Lymphotoxin-β Receptor

Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation

(2009) Rebecca A. Csomos et al.   BIOCHEMICAL JOURNAL

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

(2009) James E. Vince et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Cytoprotective Effects of the Inhibitor of Apoptosis Protein Cellular IAP1 through Stabilization with TRAF2

(2009) Rebecca A. Csomos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic control of negative feedback regulators of NF- B/RelA determines their pathogen- and cytokine-receptor signaling specificity

(2009) V. F.-S. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

(2009) Peyman Nakhaei et al.   PLoS Pathogens

The TNF receptor and Ig superfamily members form an integrated signaling circuit controlling dendritic cell homeostasis

(2008) Carl De Trez et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways

(2008) Carl F. Ware   IMMUNOLOGICAL REVIEWS

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY