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Title
Current Perspectives on HIV-1 Antiretroviral Drug Resistance
Authors
Keywords
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Journal
Viruses-Basel
Volume 6, Issue 10, Pages 4095-4139
Publisher
MDPI AG
Online
2014-10-24
DOI
10.3390/v6104095
References
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Note: Only part of the references are listed.- Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors
- (2014) Maureen Oliveira et al. AIDS
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- (2013) Aiman A. Haqqani et al. ANTIVIRAL RESEARCH
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- (2013) Laurence Rimsky et al. ANTIVIRAL THERAPY
- Resistance to HIV Integrase Strand Transfer Inhibitors Among Clinical Specimens in the United States, 2009–2012
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- (2013) Arun K. Ghosh et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2013) Thibault Mesplède et al. Retrovirology
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- (2013) Janet D Siliciano et al. Current Opinion in Virology
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- (2012) Eugene L. Asahchop et al. AIDS
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- (2012) M. Sharma et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
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- (2012) Kamalendra Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2012) Joseph J. Eron et al. JOURNAL OF INFECTIOUS DISEASES
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- (2012) H.-T. Xu et al. JOURNAL OF VIROLOGY
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- (2012) Barry C Johnson et al. Retrovirology
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- (2012) Celia Perales et al. TRENDS IN MICROBIOLOGY
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- (2010) Helen H. Lee et al. JOURNAL OF INFECTIOUS DISEASES
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- (2010) Eric B. Lansdon et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2010) R. Sanjuan et al. JOURNAL OF VIROLOGY
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- (2010) C. L. Clouser et al. JOURNAL OF VIROLOGY
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- (2010) Xiongying Tu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanistic interplay among the M184I HIV-1 reverse transcriptase mutant, the central polypurine tract, cellular dNTP concentrations and drug sensitivity
- (2010) Sarah K. Van Cor-Hosmer et al. VIROLOGY
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- (2010) Akbar Ali et al. Viruses-Basel
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- (2009) G. Yang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2009) Charles Hicks et al. CLINICAL INFECTIOUS DISEASES
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- (2009) Youcef Mehellou et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2009) Tsuyoshi Watabe et al. JOURNAL OF MOLECULAR BIOLOGY
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- (2009) M. J. Dapp et al. JOURNAL OF VIROLOGY
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- (2009) O. Delelis et al. NUCLEIC ACIDS RESEARCH
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- (2009) Delphine Lavens et al. NUCLEIC ACIDS RESEARCH
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- (2009) C. G. Anastassopoulou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) John P Moore et al. Current Opinion in HIV and AIDS
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- (2009) Elisabeth Dam et al. PLoS Pathogens
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- (2008) Eva Poveda et al. AIDS
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- (2008) Ya-Lin Chiu et al. Annual Review of Immunology
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