Advanced Vaccine Candidates for Lassa Fever

Nonmucosal Alphavirus Vaccination Stimulates a Mucosal Inductive Environment in the Peripheral Draining Lymph Node

(2014) J. M. Thompson et al.   JOURNAL OF IMMUNOLOGY

Absence of CTL Responses to Early Viral Antigens Facilitates Viral Persistence

(2014) A. Schildknecht et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells Are Productively Infected and Activated through TLR-7 Early after Arenavirus Infection

(2012) Mónica Macal et al.   Cell Host & Microbe

Toll-like Receptor 7 Is Required for Effective Adaptive Immune Responses that Prevent Persistent Virus Infection

(2012) Kevin B. Walsh et al.   Cell Host & Microbe

Clinical development of IMOJEV®—a recombinant Japanese encephalitis chimeric vaccine (JE-CV)

(2012) Mohan Babu Appaiahgari et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Technologies for enhanced efficacy of DNA vaccines

(2012) Fadi Saade et al.   Expert Review of Vaccines

ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases

(2012) A. Baz Morelli et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Cell Surface Molecules Involved in Infection Mediated by Lymphocytic Choriomeningitis Virus Glycoprotein

(2012) Masayuki SHIMOJIMA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Pathogenic Old World Arenaviruses Inhibit TLR2/Mal-Dependent Proinflammatory Cytokines In Vitro

(2012) M. W. Hayes et al.   JOURNAL OF VIROLOGY

Functional Interferon System Is Required for Clearance of Lassa Virus

(2012) N. E. Yun et al.   JOURNAL OF VIROLOGY

Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever

(2012) K. G. Andersen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Impact of Human Conflict on the Genetics of Mastomys natalensis and Lassa Virus in West Africa

(2012) Aude Lalis et al.   PLoS One

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model

(2012) Marco A. Goicochea et al.   VACCINE

Identification, Characterization, and In Vitro Culture of Highly Divergent Arenaviruses from Boa Constrictors and Annulated Tree Boas: Candidate Etiological Agents for Snake Inclusion Body Disease

(2012) M. D. Stenglein et al.   mBio

Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses

(2012) Kathryn M Hastie et al.   Current Opinion in Virology

Junín Virus Infection Activates the Type I Interferon Pathway in a RIG-I-Dependent Manner

(2012) Cheng Huang et al.   PLoS Neglected Tropical Diseases

Alphavirus replicon vaccines

(2012) Ryan L. Vander Veen et al.   ANIMAL HEALTH RESEARCH REVIEWS

Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever

(2011) Juan C. Zapata et al.   ANTIVIRAL RESEARCH

Ebola and Marburg haemorrhagic fever viruses: major scientific advances, but a relatively minor public health threat for Africa

(2011) E.M. Leroy et al.   CLINICAL MICROBIOLOGY AND INFECTION

Vaccines against viral hemorrhagic fevers: Non-human primate models

(2011) Ricardo Carrion Jr. et al.   Human vaccines & immunotherapeutics

Argentine hemorrhagic fever vaccines

(2011) Ana Ambrosio et al.   Human vaccines & immunotherapeutics

Common marmoset (Callithrix jacchus) as a primate model of dengue virus infection: development of high levels of viraemia and demonstration of protective immunity

(2011) T. Omatsu et al.   JOURNAL OF GENERAL VIROLOGY

Recombinant Vesicular Stomatitis Virus–Based Vaccines Against Ebola and Marburg Virus Infections

(2011) Thomas W. Geisbert et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of Cell Surface Molecules Involved in Dystroglycan-Independent Lassa Virus Cell Entry

(2011) M. Shimojima et al.   JOURNAL OF VIROLOGY

Molecular Determinants of Arenavirus Z Protein Homo-Oligomerization and L Polymerase Binding

(2011) M. E. Loureiro et al.   JOURNAL OF VIROLOGY

Cross-Species Analysis of the Replication Complex of Old World Arenaviruses Reveals Two Nucleoprotein Sites Involved in L Protein Function

(2011) R. Kerber et al.   JOURNAL OF VIROLOGY

Efficient Rescue of Recombinant Lassa Virus Reveals the Influence of S Segment Noncoding Regions on Virus Replication and Virulence

(2011) C. G. Albarino et al.   JOURNAL OF VIROLOGY

Substitutions in the Glycoprotein (GP) of the Candid#1 Vaccine Strain of Junin Virus Increase Dependence on Human Transferrin Receptor 1 for Entry and Destabilize the Metastable Conformation of GP

(2011) M. E. Droniou-Bonzom et al.   JOURNAL OF VIROLOGY

The Major Determinant of Attenuation in Mice of the Candid1 Vaccine for Argentine Hemorrhagic Fever Is Located in the G2 Glycoprotein Transmembrane Domain

(2011) C. G. Albarino et al.   JOURNAL OF VIROLOGY

Lassa Virus Nucleoprotein Mutants Generated by Reverse Genetics Induce a Robust Type I Interferon Response in Human Dendritic Cells and Macrophages

(2011) X. Carnec et al.   JOURNAL OF VIROLOGY

Human Dendritic Cells Infected with the Nonpathogenic Mopeia Virus Induce Stronger T-Cell Responses than Those Infected with Lassa Virus

(2011) D. Pannetier et al.   JOURNAL OF VIROLOGY

Novel Arenavirus Sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: Implications for Evolution of Arenaviruses in Africa

(2011) David Coulibaly-N'Golo et al.   PLoS One

Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression

(2011) K. M. Hastie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From research to phase III: Preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine

(2011) Bruno Guy et al.   VACCINE

Pathogenesis of lassa fever in cynomolgus macaques

(2011) Lisa E Hensley et al.   Virology Journal

Emerging trends in Lassa fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection

(2011) Luis M Branco et al.   Virology Journal

Progress in recombinant DNA-derived vaccines for Lassa virus and filoviruses

(2011) Rebecca J. Grant-Klein et al.   VIRUS RESEARCH

Pathogenesis of arenavirus hemorrhagic fevers

(2010) Marie-Laurence Moraz et al.   Expert Review of Anti-Infective Therapy

Progress in filovirus vaccine development: evaluating the potential for clinical use

(2010) Darryl Falzarano et al.   Expert Review of Vaccines

Genomic and phylogenetic characterization of Merino Walk virus, a novel arenavirus isolated in South Africa

(2010) G. Palacios et al.   JOURNAL OF GENERAL VIROLOGY

A Multivalent Vaccination Strategy for the Prevention of Old World Arenavirus Infection in Humans

(2010) J. Botten et al.   JOURNAL OF VIROLOGY

Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques

(2010) M. C. Bonaldo et al.   JOURNAL OF VIROLOGY

Viral Protein Determinants of Lassa Virus Entry and Release from Polarized Epithelial Cells

(2010) K. Schlie et al.   JOURNAL OF VIROLOGY

Cap binding and immune evasion revealed by Lassa nucleoprotein structure

(2010) Xiaoxuan Qi et al.   NATURE

Rationalizing the development of live attenuated virus vaccines

(2010) Adam S Lauring et al.   NATURE BIOTECHNOLOGY

Comparison of the Immune Responses Induced by Chimeric Alphavirus-Vectored and Formalin-Inactivated Alum-Precipitated Measles Vaccines in Mice

(2010) M. Jeff Bergen et al.   PLoS One

Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii

(2010) Cristina T. Stoyanov et al.   VACCINE

Yellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs

(2010) Xiaohong Jiang et al.   VACCINE

Alphavirus replicon-based adjuvants enhance the immunogenicity and effectiveness of Fluzone® in rhesus macaques

(2010) Timothy D. Carroll et al.   VACCINE

Establishing Efficacy of Human Products Using Animals

(2010) P. J. Snoy   VETERINARY PATHOLOGY

Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response

(2010) Michael B.A. Oldstone et al.   VIROLOGY

Lassa virus-like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever

(2010) Luis M Branco et al.   Virology Journal

Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection

(2010) Persephone Borrow et al.   Viruses-Basel

T Cell-Dependence of Lassa Fever Pathogenesis

(2010) Lukas Flatz et al.   PLoS Pathogens

Clinical and Immunological Insights on Severe, Adverse Neurotropic and Viscerotropic Disease following 17D Yellow Fever Vaccination

(2009) M. L. Silva et al.   Clinical and Vaccine Immunology

Innate immune control of nucleic acid-based vaccine immunogenicity

(2009) Shohei Koyama et al.   Expert Review of Vaccines

Arenavirus genetic diversity and its biological implications

(2009) Sebastien F. Emonet et al.   INFECTION GENETICS AND EVOLUTION

Characterization of Lassa Virus Cell Entry and Neutralization with Lassa Virus Pseudoparticles

(2009) F.-L. Cosset et al.   JOURNAL OF VIROLOGY

Early and Strong Immune Responses Are Associated with Control of Viral Replication and Recovery in Lassa Virus-Infected Cynomolgus Monkeys

(2009) S. Baize et al.   JOURNAL OF VIROLOGY

An N-Terminal Region of Lassa Virus L Protein Plays a Critical Role in Transcription but Not Replication of the Virus Genome

(2009) M. Lelke et al.   JOURNAL OF VIROLOGY

Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus

(2009) L. Martinez-Sobrido et al.   JOURNAL OF VIROLOGY

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Preclinical and clinical development of YFV 17D-based chimeric vaccines against dengue, West Nile and Japanese encephalitis viruses

(2009) Bruno Guy et al.   VACCINE

Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus–host interaction

(2009) Stefan Kunz   VIROLOGY

Risk Maps of Lassa Fever in West Africa

(2009) Elisabeth Fichet-Calvet et al.   PLoS Neglected Tropical Diseases

Genetic Detection and Characterization of Lujo Virus, a New Hemorrhagic Fever–Associated Arenavirus from Southern Africa

(2009) Thomas Briese et al.   PLoS Pathogens

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY

Phylogeny of the genus Arenavirus

(2008) Rémi N Charrel et al.   CURRENT OPINION IN MICROBIOLOGY

Post-translational modification of  -dystroglycan is not critical for lymphocytic choriomeningitis virus receptor function in vivo

(2008) M. Imperiali et al.   JOURNAL OF GENERAL VIROLOGY

MyD88 Intrinsically Regulates CD4 T-Cell Responses

(2008) S. Zhou et al.   JOURNAL OF VIROLOGY

Basolateral Entry and Release of New and Old World Arenaviruses from Human Airway Epithelia

(2008) D. E. Dylla et al.   JOURNAL OF VIROLOGY

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

(2008) Matthias Habjan et al.   PLoS One

Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates

(2008) Igor S. Lukashevich et al.   VACCINE

Adverse event reports following yellow fever vaccination

(2008) Nicole P. Lindsey et al.   VACCINE

Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen

(2008) Joseph M. Thompson et al.   VACCINE

Animal models of highly pathogenic RNA viral infections: Hemorrhagic fever viruses

(2007) Brian B. Gowen et al.   ANTIVIRAL RESEARCH

New opportunities for field research on the pathogenesis and treatment of Lassa fever

(2007) Sheik Humarr Khan et al.   ANTIVIRAL RESEARCH