Article
Medicine, General & Internal
Bahar Behrouzi, Deepak L. Bhatt, Christopher P. Cannon, Orly Vardeny, Douglas S. Lee, Scott D. Solomon, Jacob A. Udell
Summary: This study found that influenza vaccination is associated with a lower risk of major adverse cardiovascular events, especially for patients with recent acute coronary syndrome (ACS). Providing influenza vaccination to high-risk patients is of great importance during the COVID-19 pandemic.
Article
Immunology
Sansone Pasquale, Giaccari Luca Gregorio, Aurilio Caterina, Coppolino Francesco, Passavanti Maria Beatrice, Pota Vincenzo, Pace Maria Caterina
Summary: Managing the COVID-19 pandemic is challenging for LMICs, with economic and health resource issues. Recommendations include targeted testing, personal protective measures, patient triage, and efficient resource utilization.
Review
Immunology
Kay Choong See
Summary: Monkeypox virus infection in humans is a global public health concern, with over 3000 reported cases in more than 50 countries. Adults generally have mild disease, while poorer outcomes are observed in children, immunocompromised patients, and pregnant women. The risk-benefit profile of monkeypox-specific treatments is unclear, but two effective vaccines exist for prevention. Vaccination is likely to be a key strategy for mitigating the spread of monkeypox, with priority given to healthcare workers, immunocompromised patients, and children.
Article
Medicine, Research & Experimental
Wandi Zhu, Lai Wei, Chunhong Dong, Ye Wang, Joo Kim, Yao Ma, Gilbert X. Gonzalez, Bao-Zhong Wang
Summary: mRNA lipid nanoparticle vaccines can induce strong cellular and antibody immune responses when administered through cutaneous immunization. The addition of cGAMP as an adjuvant enhances the immunogenicity of the vaccine, leading to stronger immune responses compared to other adjuvants.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Multidisciplinary Sciences
Ibrahim A. Naqid, Ahmed A. Mosa, Shah Vahel Ibrahim, Nizar Hussein Ibrahim, Nawfal R. Hussein
Summary: The study aims to determine the knowledge of the Hepatitis B virus among medical professionals in Duhok province, Kurdistan Region of Iraq, and to determine their knowledge of the importance of vaccination.
Article
Medicine, General & Internal
Chengyi Zheng, Jonathan Duffy, In-Lu Amy Liu, Lina S. Sy, Wansu Chen, Lei Qian, Ronald A. Navarro, Denison S. Ryan, Sunhea S. Kim, Cheryl Mercado, Steven J. Jacobsen
Summary: This retrospective cohort study estimated the risk for shoulder conditions after vaccination and identified possible risk factors. The results suggest a small absolute risk for shoulder conditions after vaccination, with factors such as age, sex, outpatient visits, comorbidity index, and vaccine type associated with an increased risk of shoulder conditions.
ANNALS OF INTERNAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Macarena Martinez-Bailen, Javier Rojo, Javier Ramos-Soriano
Summary: Human lectins play important roles in various biological processes and have attracted the attention of researchers in the glycoscience field. Multivalent glycosystems have been used as valuable tools to study carbohydrate-lectin binding and for biomedical applications. This review summarizes the different scaffolds designed for multivalent presentation of sugars and their interactions with lectins, highlighting the progress in this active field. Overall, this paper provides relevant information on carbohydrate-lectin interactions and contributes to our understanding of this topic.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Cell Biology
Michel P. M. Vierboom, Karin Dijkman, Claudia C. Sombroek, Sam O. Hofman, Charelle Boot, Richard A. W. Vervenne, Krista G. Haanstra, Maarten van der Sande, Liesbeth van Emst, Jorge Dominguez-Andres, Simone J. C. F. M. Moorlag, Clemens H. M. Kocken, Jelle Thole, Esteban Rodriguez, Eugenia Puentes, Joost H. A. Martens, Reinout van Crevel, Mihai G. Netea, Nacho Aguilo, Carlos Martin, Frank A. W. Verreck
Summary: BCG vaccination can enhance protection against pathogens by inducing epigenetic and metabolic reprogramming of innate immune cells, known as trained immunity. In rhesus macaques, intravenous BCG was shown to better protect against Mycobacterium tuberculosis infection and TB disease compared to standard intradermal vaccination, correlating with local adaptive immune signatures. Additionally, mucosal vaccination, either with BCG or the MTBVAC candidate, was found to enhance innate cytokine production by monocytes derived from blood and bone marrow, showing metabolic rewiring typical of trained immunity.
CELL REPORTS MEDICINE
(2021)
Article
Medicine, General & Internal
Scott C. Brakenridge, Uan- Chen, Tyler Loftus, Ricardo Ungaro, Marvin Dirain, Austin Kerr, Luer Zhong, Rhonda Bacher, Petr Starostik, Gabriella Ghita, Uros Midic, Dijoia Darden, Brittany Fenner, James Wacker, Philip A. Efron, Oliver Liesenfeld, Timothy E. Sweeney, Lyle L. Moldawer
Summary: This study developed a novel metric based on whole-blood multivalent host-messenger RNA expression to accurately assess the risk of bacterial infection and 30-day mortality. The performance of this metric was comparable to or better than other commonly used biomarkers and clinical parameters at admission, and it provided additional information over time.
Editorial Material
Biochemistry & Molecular Biology
Daniel G. Bausch
Summary: The outbreaks of Ebola virus disease in the Democratic Republic of the Congo and Republic of Guinea, amidst the COVID-19 pandemic, highlight the necessity for a revision in vaccination strategies in the area.
Editorial Material
Multidisciplinary Sciences
Justin Sandefur
Summary: International financial institutions say that vaccines are the highest-return investment on Earth and it's time for them to fulfill their commitments.
Article
Immunology
Gopika Punchhi, Rainbow Negus, Hammad Saif, Sharon Pritchard, Olivia Owen, Aman Sehmbi, Caroline Hamm
Summary: Measles outbreaks have raised concerns about fatal infections in immunocompromised patients. A retrospective study found significant differences in measles, mumps, and rubella immunity between autologous and allogeneic hematopoietic stem cell transplant recipients. A large proportion of autologous transplant patients were on contraindicated medications at two years post-transplant.
Review
Oncology
Gilla K. Shapiro
Summary: This paper synthesizes the impact of HPV on the global burden of cancer and the potential benefit of HPV vaccination. While cervical cancer is the primary concern in low- and middle-income countries, HPV-associated head and neck cancers are increasing in high-income countries and have surpassed cervical cancer in some countries. Therefore, it is critical to improve gender-neutral HPV vaccination.
Review
Medicine, General & Internal
Binshan Jiang, Qiangru Huang, Mengmeng Jia, Xinai Xue, Qing Wang, Weizhong Yang, Luzhao Feng
Summary: This study provides a systematic review of the association between influenza vaccination and COVID-19, showing that influenza vaccination can help limit SARS-CoV-2 infection and severe outcomes. However, further studies are needed for a more comprehensive understanding.
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, Research & Experimental
Ruixue Hou, Lewis E. Tomalin, Jessica Pintado Silva, Seunghee Kim-Schulze, Stephen S. Whitehead, Ana Fernandez-Sesma, Anna P. Durbin, Mayte Suarez-Farinas
Summary: Understanding the immune response to dengue virus is crucial for dengue vaccine development. This study showed that the tetravalent vaccine has better protective effects against DENV compared to the trivalent admixture. Additionally, differences in immune responses between Black and White participants were observed.
Article
Immunology
SunAh Kang, Amanda B. Keener, Shannon Z. Jones, Robert J. Benschop, Alfredo Caro-Maldonado, Jeffrey C. Rathmell, Stephen H. Clarke, Glenn K. Matsushima, Jason K. Whitmire, Barbara J. Vilen
JOURNAL OF IMMUNOLOGY
(2016)
Article
Genetics & Heredity
Andrew P. Morgan, Chen-Ping Fu, Chia-Yu Kao, Catherine E. Welsh, John P. Didion, Liran Yadgary, Leeanna Hyacinth, Martin T. Ferris, Timothy A. Bell, Darla R. Miller, Paola Giusti-Rodriguez, Randal J. Nonneman, Kevin D. Cook, Jason K. Whitmire, Lisa E. Gralinski, Mark Keller, Alan D. Attie, Gary A. Churchill, Petko Petkov, Patrick F. Sullivan, Jennifer R. Brennan, Leonard McMillan, Fernando Pardo-Manuel de Villena
G3-GENES GENOMES GENETICS
(2016)
Review
Allergy
Bradly J. Thrasher, Lee Kyung Hong, Jason K. Whitmire, Maureen A. Su
CURRENT ALLERGY AND ASTHMA REPORTS
(2016)
Article
Immunology
Kevin D. Cook, Jason K. Whitmire
JOURNAL OF IMMUNOLOGY
(2016)
Article
Multidisciplinary Sciences
Asuka Hirai-Yuki, Lucinda Hensley, David R. McGivern, Olga Gonzalez-Lopez, Anshuman Das, Hui Feng, Lu Sun, Justin E. Wilson, Fengyu Hu, Zongdi Feng, William Lovell, Ichiro Misumi, Jenny P. -Y. Ting, Stephanie Montgomery, John Cullen, Jason K. Whitmire, Stanley M. Lemon
Article
Microbiology
Asuka Hirai-Yuki, Lucinda Hensley, Jason K. Whitmire, Stanley M. Lemon
Article
Microbiology
Anshuman Das, Asuka Hirai-Yuki, Olga Gonzalez-Lopez, Bethany Rhein, Sven Moller-Tank, Rachel Brouillette, Lucinda Hensley, Ichiro Misumi, William Lovell, John M. Cullen, Jason K. Whitmire, Wendy Maury, Stanley M. Lemon
Article
Medicine, Research & Experimental
Asuka Hirai-Yuki, Jason K. Whitmire, Michael Joyce, D. Lorne Tyrrell, Stanley M. Lemon
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2019)
Article
Immunology
Toru Uchimura, Yoshitaka Oyama, Meng Deng, Haitao Guo, Justin E. Wilson, Elena Rampanelli, Kevin D. Cook, Ichiro Misumi, Xianming Tan, Liang Chen, Brandon Johnson, Jason Tam, Wei-Chun Chou, W. June Brickey, Alex Petrucelli, Jason K. Whitmire, Jenny P. Y. Ting
Article
Cell Biology
Ichiro Misumi, Joshua Starmer, Toru Uchimura, Melinda A. Beck, Terry Magnuson, Jason K. Whitmire
Article
Cell Biology
Ichiro Misumi, Kevin D. Cook, Joseph E. Mitchell, Makayla M. Lund, Sarah C. Vick, Robert H. Lee, Toru Uchimura, Wolfgang Bergmeier, Piotr Mieczkowski, Fernando Pardo-Manuel de Villena, Jenny P. Y. Ting, Jason K. Whitmire
Article
Microbiology
Daisuke Yamane, Hui Feng, Efrain E. Rivera-Serrano, Sara R. Selitsky, Asuka Hirai-Yuki, Anshuman Das, Kevin L. McKnight, Ichiro Misumi, Lucinda Hensley, William Lovell, Olga Gonzalez-Lopez, Ryosuke Suzuki, Mami Matsuda, Hiroki Nakanishi, Takayo Ohto-Nakanishi, Takayuki Hishiki, Eliane Wauthier, Tsunekazu Oikawa, Kouichi Morita, Lola M. Reid, Praveen Sethupathy, Michinori Kohara, Jason K. Whitmire, Stanley M. Lemon
NATURE MICROBIOLOGY
(2019)
Article
Gastroenterology & Hepatology
Ichiro Misumi, Joseph E. Mitchell, Makayla M. Lund, John M. Cullen, Stanley M. Lemon, Jason K. Whitmire
Summary: The study shows that T cells protect against liver injury caused by HAV and can be targeted to improve liver health.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Chandrav De, Raymond J. Pickles, Wenbo Yao, Baolin Liao, Allison Boone, Mingyu Choi, Diana M. Battaglia, Frederic B. Askin, Jason K. Whitmire, Guido Silvestri, J. Victor Garcia, Angel Wahl
Summary: RSV infection causes severe morbidity and mortality in high-risk groups. The study demonstrated the extensive lung damage, proinflammatory immune response and protective adaptive immune response against RSV infection. Human T cells, specifically primed CD8+ T cells or CD4+ T cells, played a key role in controlling RSV replication in the absence of RSV-specific antibodies. These findings support the development of RSV vaccines to improve efficacy by inducing effective T cell responses.
Article
Immunology
Hui Feng, Erik M. Lenarcic, Daisuke Yamane, Eliane Wauthier, Jinyao Mo, Haitao Guo, David R. McGivern, Olga Gonzalez-Lopez, Ichiro Misumi, Lola M. Reid, Jason K. Whitmire, Jenny P-Y Ting, Joseph A. Duncan, Nathaniel J. Moorman, Stanley M. Lemon