Article
Biochemistry & Molecular Biology
Justin Taft, Michael Markson, Diana Legarda, Roosheel Patel, Mark Chan, Louise Malle, Ashley Richardson, Conor Gruber, Marta Martin-Fernandez, Grazia M. S. Mancini, Jan A. M. van Laar, Philomine van Pelt, Sofija Buta, Beatrijs H. A. Wokke, Ira K. D. Sabli, Vanessa Sancho-Shimizu, Pallavi Pimpale Chavan, Oskar Schnappauf, Raju Khubchandani, Muserref Kasap Cuceoglu, Seza Ozen, Daniel L. Kastner, Adrian T. Ting, Ivona Aksentijevich, Iris H. I. M. Hollink, Dusan Bogunovic
Summary: The loss of TBK1 leads to decreased IFN-I induction but affects autoinflammation and TNF-induced cell death, and treatment with anti-TNF can improve the clinical condition of patients.
Article
Medicine, Research & Experimental
Younglang Lee, Alex W. Wessel, Jiazhi Xu, Julia G. Reinke, Eries Lee, Somin M. Kim, Amy P. Hsu, Jevgenia Zilberman-Rudenko, Sha Cao, Clinton Enos, Stephen R. Brooks, Zuoming Deng, Bin Lin, Adriana A. de Jesus, Daniel N. Hupalo, Daniela G. P. Piotto, Maria T. Terreri, Victoria R. Dimitriades, Clifton L. Dalgard, Steven M. Holland, Raphaela Goldbach-Mansky, Richard M. Siegel, Eric P. Hanson
Summary: This study characterized a pediatric autoinflammatory syndrome called NEMO deleted exon 5 autoinflammatory syndrome (NDAS) in three unrelated male patients. The syndrome is caused by distinct X-linked IKBKG germline mutations that lead to overexpression of a NEMO protein isoform lacking the domain encoded by exon 5 (NEMO-Aex5). The patients exhibited increased NF-KB activation and IFN production in immune cells and blood cells.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Yihua Zhang, Bowen Xin, Yinan Liu, Wenyi Jiang, Wendong Han, Jian Deng, Peihui Wang, Xiaowu Hong, Dapeng Yan
Summary: This study reveals a previously unknown mechanism by which the SARS-COV-2 protein NSP9 promotes cytokine storm and tissue damage. NSP9 interacts with and activates TBK1, leading to increased cytokine production. Additionally, NSP9 is ubiquitinated and degraded by MID1, but virus infection inhibits this degradation process. These findings provide insights into the pathogenesis of COVID-19 and present a potential target for therapeutic intervention.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Seoyun Yum, Minghao Li, Yan Fang, Zhijian J. Chen
Summary: This study shows that STING can function independently of type I interferons and autophagy, and that TBK1 recruitment to STING is essential for antiviral and antitumor immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Chao Sui, Tongyang Xiao, Shengyuan Zhang, Hongxiang Zeng, Yi Zheng, Bingyu Liu, Gang Xu, Chengjiang Gao, Zheng Zhang
Summary: This study reveals that SARS-CoV-2 inhibits the host interferon response by using NSP13 to recruit TBK1 for autophagic degradation. The findings provide new insights into the transmission and pathogenesis of SARS-CoV-2 infection.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Nathalie Scrima, Romain Le Bars, Quentin Nevers, Damien Glon, Guillaume Chevreux, Ahmet Civas, Danielle Blondel, Cecile Lagaudriere-Gesbert, Yves Gaudin
Summary: Rabies virus P protein can inhibit interferon production by binding to TBK1, which is a key kinase in interferon induction pathways. This study reveals that upon RABV infection or detection of dsRNA, TBK1 and its adaptor proteins can form liquid condensates in the cytoplasm, and P protein binding disrupts the formation of these structures.
Article
Immunology
Felix B. He, Hira Khan, Moona Huttunen, Pekka Kolehmainen, Krister Melen, Sari Maljanen, Mengmeng Qu, Miao Jiang, Laura Kakkola, Ilkka Julkunen
Summary: Filovirus family is a highly pathogenic virus family that has caused deadly outbreaks, especially in African countries. Previous research has focused on Ebola, Sudan, and Marburg viruses, leaving other filoviruses less studied. These viruses have the ability to downregulate the innate immune system, and VP24 proteins have been shown to interfere with interferon gene expression and signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Yuexuan Wang, Qi Zheng, Suifeng Xu, Yewen Wang, Youhua Huang, Xiaohong Huang, Jingguang Wei, Qiwei Qin, Shina Wei
Summary: The study found that Stearoyl-CoA desaturase 1 (SCD1) plays a crucial role in fish virus infection. Overexpression of SCD1 promoted the infection of Singapore grouper iridovirus (SGIV) and suppressed interferon (IFN) immune responses. Additionally, SCD1 overexpression facilitated the formation of lipid droplets, which were essential for virus replication.
Article
Cell Biology
Thomas Clapes, Aikaterini Polyzou, Pia Prater, Sagar, Antonio Morales-Hernandez, Mariana Galvao Ferrarini, Natalie Kehrer, Stylianos Lefkopoulos, Veronica Bergo, Barbara Hummel, Nadine Obier, Daniel Maticzka, Anne Bridgeman, Josip S. Herman, Ibrahim Ilik, Lheanna Klaeyle, Jan Rehwinkel, Shannon McKinney-Freeman, Rolf Backofen, Asifa Akhtar, Nina Cabezas-Wallscheid, Ritwick Sawarkar, Rita Rebollo, Dominic Gruen, Eirini Trompouki
Summary: Chemotherapy induces chromatin reorganization and increased expression of transposable elements in HSCs, promoting an MDA5-driven inflammatory response that enhances haematopoietic regeneration.
NATURE CELL BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Yongkui Li, Ying Huang, Pan Pan, Xu Che, Yaru Zhang, Yeshun Zhang, Algahtany Amal, Xin Li, Wenjing Niu, Nachuan Luo, Wen Zhang, Daolong Gao, Qiuping Tan, Qiwei Zhang, Xiwen Xing, Zhen Luo, Jianguo Wu
Summary: The study reveals that sericin and its derived peptide F5-SP enhance antiviral innate immune response by inhibiting lactate production, showing promising antiviral activity both in vitro and in vivo. This discovery suggests a new biomedical application of sericin in the prevention and treatment of viral infectious diseases.
APPLIED MATERIALS TODAY
(2021)
Article
Cell Biology
Xibao Zhao, Qianqian Di, Juan Yu, Jiazheng Quan, Yue Xiao, Huihui Zhu, Hongrui Li, Jing Ling, Weilin Chen
Summary: Research has shown that USP19 plays a crucial role in promoting TBK1 lysosomal degradation through chaperone-mediated autophagy, contributing to immune response and infectious diseases. This study uncovers a novel role for USP19 in CMA-mediated TBK1 degradation.
Article
Microbiology
Qinting Dong, Xinyue Zhu, Leping Wang, Wenchao Zhang, Lifei Lu, Jun Li, Shuhong Zhong, Chunxia Ma, Kang Ouyang, Ying Chen, Zuzhang Wei, Yifeng Qin, Hao Peng, Weijian Huang
Summary: Porcine astrovirus type 1 (PAstV1) induces the production of IFN-beta through the IRF3 signaling pathway and inhibits viral replication. Knockdown of RIG-I and MDA5 results in decreased expression of IFN-beta and increased viral replication induced by PAstV1.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
John Victor Napoleon, Satish Sagar, Sydney P. Kubica, Lidia Boghean, Smit Kour, Hannah M. King, Yogesh A. Sonawane, Ayrianne J. Crawford, Nagsen Gautam, Smitha Kizhake, Pawel A. Bialk, Eric Kmiec, Jayapal Reddy Mallareddy, Prathamesh P. Patil, Sandeep Rana, Sarbjit Singh, Janani Prahlad, Paul M. Grandgenett, Gloria E. O. Borgstahl, Gargi Ghosal, Yazen Alnouti, Michael A. Hollingsworth, Prakash Radhakrishnan, Amarnath Natarajan
Summary: Activation of IKK beta, characterized by phosphorylation of serine residues 177 and 181, has been implicated in the early onset of cancer. This study used various models to assess the role of IKK beta and its activation in cancer, and identified 39-100 as a potent inhibitor of MAP3K1. It was found that IKK beta activation is critical for tumor growth in Kras mutant pancreatic cancer, and the compound 39-100 inhibits MAP3K1-mediated IKK beta phosphorylation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Zhenzhen Yan, Haifeng Wu, Hansen Liu, Guimin Zhao, Honghai Zhang, Wanxin Zhuang, Feng Liu, Yi Zheng, Bingyu Liu, Lei Zhang, Chengjiang Gao
Summary: PRMT1 is an essential regulator of TBK1 activation, promoting its oligomerization and subsequent interferon production through asymmetric methylation. Mice with myeloid-specific Prmt1 knockout are more susceptible to infection with DNA and RNA viruses.
Article
Pharmacology & Pharmacy
Gina Cordoba-David, Jorge Garcia-Gimenez, Regiane Cardoso Castelo-Branco, Susana Carrasco, Pablo Cannata, Alberto Ortiz, Adrian M. Ramos
Summary: The study investigates the impact of the type I interferon (TI-IFN) pathway and upstream signaling pathways on tubular injury in kidney disease. The results demonstrate that activation of the TI-IFN pathway and upstream signaling pathways leads to proinflammatory and antiviral responses in tubular cells. Pharmacological inhibition and gene knockdown experiments reveal that inhibition of TBK1/IKK epsilon and IFNAR can protect against tubular injury.
FRONTIERS IN PHARMACOLOGY
(2022)