Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes

Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures andin silicomodeling

(2012) Dong Dong et al.   DRUG METABOLISM REVIEWS

First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics

(2011) Baojian Wu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms

(2011) Baojian Wu et al.   PHARMACEUTICAL RESEARCH

The Molecular Basis for the Broad Substrate Specificity of Human Sulfotransferase 1A1

(2011) Ilana Berger et al.   PLoS One

Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity

(2011) A. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases

(2011) Sanna Kaivosaari et al.   XENOBIOTICA

Three-Dimensional Quantitative Structure-Activity Relationship Studies on UGT1A9-Mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-Based Comparative Molecular Field Analysis Model

(2010) B. Wu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9

(2010) Shenggu Xie et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Influence of N-Terminal Domain Histidine and Proline Residues on the Substrate Selectivities of Human UDP-Glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10

(2009) O. Kerdpin et al.   DRUG METABOLISM AND DISPOSITION

The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families

(2009) Anna Radominska-Pandya et al.   DRUG METABOLISM REVIEWS

Crystal Structures of Glycosyltransferase UGT78G1 Reveal the Molecular Basis for Glycosylation and Deglycosylation of (Iso)flavonoids

(2009) Luzia V. Modolo et al.   JOURNAL OF MOLECULAR BIOLOGY

Substrate specificity of plant UDP-dependent glycosyltransferases predicted from crystal structures and homology modeling

(2009) Sarah A. Osmani et al.   PHYTOCHEMISTRY

Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli

(2008) Xian-Zhi He et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biochemical and Structural Insights of the Early Glycosylation Steps in Calicheamicin Biosynthesis

(2008) Changsheng Zhang et al.   CHEMISTRY & BIOLOGY

Recent Advances in the In Silico Modelling of UDP Glucuronosyltransferase Substrates

(2008) Michael Sorich et al.   CURRENT DRUG METABOLISM

Pharmacogenetics of Gilbert’s syndrome

(2008) Christian P Strassburg   PHARMACOGENOMICS

Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases

(2008) A.-S. Patana et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry

Exploring the sequence-structure protein landscape in the glycosyltransferase family

(2003) Ziding Zhang et al.   PROTEIN SCIENCE