Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures andin silicomodeling

Methodologies for Investigating Drug Metabolism at the Early Drug Discovery Stage: Prediction of Hepatic Drug Clearance and P450 Contribution

(2011) Chie Emoto et al.   CURRENT DRUG METABOLISM

Clinical Drugs Undergoing Polymorphic Metabolism by Human Cytochrome P450 2C9 and the Implication in Drug Development

(2011) S.-M. He et al.   CURRENT MEDICINAL CHEMISTRY

Substrate inhibition kinetics in drug metabolism reactions

(2011) Baojian Wu   DRUG METABOLISM REVIEWS

Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains

(2011) M. B. Shah et al.   MOLECULAR PHARMACOLOGY

New Insights into the Structural Features and Functional Relevance of Human Cytochrome P450 2C9. Part I

(2010) Sui-Lin Mo et al.   CURRENT DRUG METABOLISM

Molecular Modeling of Cytochrome P450 and Drug Metabolism

(2010) Jing-Fang Wang et al.   CURRENT DRUG METABOLISM

Human Cytochrome P450 2E1 Structures with Fatty Acid Analogs Reveal a Previously Unobserved Binding Mode

(2010) Patrick R. Porubsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization of the Complex between α-Naphthoflavone and Human Cytochrome P450 1B1

(2010) An Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-A Resolution

(2010) S. C. Gay et al.   MOLECULAR PHARMACOLOGY

Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir

(2010) I. F. Sevrioukova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the Substrate Specificity, Inhibitors, Regulation, and Polymorphisms and the Clinical Impact of Human Cytochrome P450 1A2

(2009) Shu-Feng Zhou et al.   AAPS Journal

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2

(2009) Shu-Feng Zhou et al.   DRUG METABOLISM REVIEWS

Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity

(2009) D. F. V. Lewis et al.   XENOBIOTICA

Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants

(2008) Y. Tu et al.   DRUG METABOLISM AND DISPOSITION

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

(2008) Dmitri R Davydov et al.   Expert Opinion on Drug Metabolism & Toxicology

Determinants of Cytochrome P450 2C8 Substrate Binding

(2008) Guillaume A. Schoch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a New Predictive Model for Interactions with Human Cytochrome P450 2A6 Using Pharmacophore Ensemble/Support Vector Machine (PhE/SVM) Approach

(2008) Max K. Leong et al.   PHARMACEUTICAL RESEARCH

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY