Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis

Autotaxin Is Regulated by Glucose and Insulin in Adipocytes

(2017) Kenneth D’Souza et al.   ENDOCRINOLOGY

Hepatocyte autotaxin expression promotes liver fibrosis and cancer

(2017) Eleanna Kaffe et al.   HEPATOLOGY

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication

(2017) Michelle J. Farquhar et al.   JOURNAL OF HEPATOLOGY

Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain

(2017) María Velasco et al.   NEUROPHARMACOLOGY

Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels

(2016) Kenichiro Enooku et al.   PLoS One

Comparative analyses of lysophosphatidic acid receptor-mediated signaling

(2015) Nobuyuki Fukushima et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease

(2015) Guoxun Chen   CURRENT DRUG TARGETS

Lysophosphatidic acid signalling in development

(2015) X. Sheng et al.   DEVELOPMENT

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate

(2015) Matthew G. K. Benesch et al.   JOURNAL OF LIPID RESEARCH

Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity

(2015) Vikrant P. Rachakonda et al.   Obesity

Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity

(2015) Valerie L. Reeves et al.   Obesity

Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer

(2015) Efrosini Barbayianni et al.   PROGRESS IN LIPID RESEARCH

A transgenic mouse model for the in vivo bioluminescence imaging of the expression of the lysophosphatidic acid receptor 3: relevance for inflammation and uterine physiology research

(2015) Chenqi Zhao et al.   TRANSGENIC RESEARCH

Lysophosphatidic acid receptor-5 negatively regulates cellular responses in mouse fibroblast 3T3 cells

(2014) Yan Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interaction of platelet-derived autotaxin with tumor integrin  V 3 controls metastasis of breast cancer cells to bone

(2014) R. Leblanc et al.   BLOOD

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma

(2014) Mayuko Kondo et al.   CLINICA CHIMICA ACTA

ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity

(2014) S. Nishimura et al.   DIABETES

Inhibitory effects of lysophosphatidic acid receptor-5 on cellular functions of sarcoma cells

(2014) Mutsumi Araki et al.   GROWTH FACTORS

Lysophosphatidic acid as a lipid mediator with multiple biological actions

(2014) S. Aikawa et al.   JOURNAL OF BIOCHEMISTRY

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Autotaxin and LPA 1 and LPA 5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

(2014) Sue-Chin Lee et al.   MOLECULAR CANCER RESEARCH

In Silico Analysis of Missense Mutations in LPAR6 Reveals Abnormal Phospholipid Signaling Pathway Leading to Hypotrichosis

(2014) Syed Irfan Raza et al.   PLoS One

Serum Autotaxin Is a Parameter for the Severity of Liver Cirrhosis and Overall Survival in Patients with Liver Cirrhosis – A Prospective Cohort Study

(2014) Thomas Pleli et al.   PLoS One

Towards selective lysophospholipid GPCR modulators

(2014) Julia K. Archbold et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

(2014) Gülsüm Özlem Elpek   WORLD JOURNAL OF GASTROENTEROLOGY

Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis

(2013) Chloé Rancoule et al.   BIOCHIMIE

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice

(2013) C. Rancoule et al.   DIABETOLOGIA

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic schwann cell migration, myelination, and cell-to-axon segregation

(2013) Brigitte Anliker et al.   GLIA

Plasma Proteome Analysis Reveals Overlapping, yet Distinct Mechanisms of Immune Activation in Chronic HCV and HIV Infections

(2013) Daniela M. Schlatzer et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Simultaneous profiling of polar lipids by supercritical fluid chromatography/tandem mass spectrometry with methylation

(2013) Jae Won Lee et al.   JOURNAL OF CHROMATOGRAPHY A

Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis

(2013) Z. Bai et al.   JOURNAL OF IMMUNOLOGY

Current progress in non-Edg family LPA receptor research

(2012) Keisuke Yanagida et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lysophospholipid receptor activation of RhoA and lipid signaling pathways

(2012) Sunny Yang Xiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish

(2012) S.-L. Lai et al.   DEVELOPMENT

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions

(2012) Andreas E. Kremer et al.   HEPATOLOGY

The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans

(2012) Anna J. S. Houben et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depot-specific regulation of autotaxin with obesity in human adipose tissue

(2012) Chloé Rancoule et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Autotaxin and Its Product Lysophosphatidic Acid Suppress Brown Adipose Differentiation and Promote Diet-Induced Obesity in Mice

(2012) Lorenzo Federico et al.   MOLECULAR ENDOCRINOLOGY

Update on activities at the Universal Protein Resource (UniProt) in 2013

(2012)   NUCLEIC ACIDS RESEARCH

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

(2012) Melissa N. Barber et al.   PLoS One

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway

(2011) L. Li et al.   Biochemistry and Cell Biology

Autotaxin as a novel serum marker of liver fibrosis

(2011) Hayato Nakagawa et al.   CLINICA CHIMICA ACTA

Identification and biochemical characterization of a novel autotaxin isoform, ATX , with a four-amino acid deletion

(2011) T. Hashimoto et al.   JOURNAL OF BIOCHEMISTRY

Non-Edg family LPA receptors: the cutting edge of LPA research

(2011) K. Yanagida et al.   JOURNAL OF BIOCHEMISTRY

Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells

(2011) Zachary Fulkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

(2011) Rodolphe Dusaulcy et al.   JOURNAL OF LIPID RESEARCH

Insights into autotaxin: how to produce and present a lipid mediator

(2011) Wouter H. Moolenaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of substrate discrimination and integrin binding by autotaxin

(2011) Jens Hausmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

(2011) Hiroshi Nishimasu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release

(2011) Anders Lundequist et al.   PLoS One

LPA Is a Chemorepellent for B16 Melanoma Cells: Action through the cAMP-Elevating LPA5 Receptor

(2011) Maikel Jongsma et al.   PLoS One

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

Differential involvement of caveolin-1 in brown adipocyte signaling: Impaired β3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling

(2010) Charlotte L. Mattsson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biological roles of lysophosphatidic acid signaling through its production by autotaxin

(2010) Shinichi Okudaira et al.   BIOCHIMIE

LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis

(2010) H. Sumida et al.   BLOOD

A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp

(2010) S. Nahum et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Effects of lysophosphatidic acid on the in vitro proliferation and differentiation of a novel porcine preadipocyte cell line

(2010) Hiroyuki Nobusue et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes

(2010) Therese E. Holmström et al.   EXPERIMENTAL CELL RESEARCH

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

(2010) Andreas E. Kremer et al.   GASTROENTEROLOGY

Abnormalities in α/β-CaMKII and related mechanisms suggest synaptic dysfunction in hippocampus of LPA1 receptor knockout mice

(2010) Laura Musazzi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review

(2010) J J Reilly et al.   INTERNATIONAL JOURNAL OF OBESITY

Autotaxin--an LPA producing enzyme with diverse functions

(2010) K. Nakanaga et al.   JOURNAL OF BIOCHEMISTRY

LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4

(2010) Yao-Bin Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography–electrospray tandem mass spectrometry

(2010) Niina Aaltonen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Altered food consumption in mice lacking lysophosphatidic acid receptor-1

(2010) R. Dusaulcy et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Autotaxin expression and its connection with the TNF-alpha-NF-κB axis in human hepatocellular carcinoma

(2010) Jian-Min Wu et al.   Molecular Cancer

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

(2010) J. Chun et al.   PHARMACOLOGICAL REVIEWS

LPA3, a unique G protein-coupled receptor for lysophosphatidic acid

(2010) Kotaro Hama et al.   PROGRESS IN LIPID RESEARCH

P2Y5 is a Gαi, Gα12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion

(2009) Mike Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Phosphatidic acid potentiates Gαq stimulation of phospholipase C-β1 signaling

(2009) Irene Litosch   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The synergistic effects of lysophosphatidic acid receptor agonists and calcitriol on MG63 osteoblast maturation at titanium and hydroxyapatite surfaces

(2009) Jason P. Mansell et al.   BIOMATERIALS

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

(2009) Shuying Liu et al.   CANCER CELL

Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells

(2009) Silvia Jansen et al.   CANCER LETTERS

Autotaxin

(2009) Jean A. Boutin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

High-Throughput Analysis of Sphingosine 1-Phosphate, Sphinganine 1-Phosphate, and Lysophosphatidic Acid in Plasma Samples by Liquid Chromatography-Tandem Mass Spectrometry

(2009) M. Scherer et al.   CLINICAL CHEMISTRY

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

(2009) E. Arner et al.   DIABETES

Impaired Preadipocyte Differentiation in Human Abdominal Obesity: Role of Wnt, Tumor Necrosis Factor- , and Inflammation

(2009) P. Isakson et al.   DIABETES

Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA5 and NHERF2

(2009) Songbai Lin et al.   GASTROENTEROLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

(2009) Keisuke Yanagida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis

(2009) Zehra Pamuklar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Ligand Selectivity of the GPR92/LPA5Lysophosphatidate Receptor Indicates Role in Human Platelet Activation

(2009) Jesica R. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol

(2009) Kumiko Makide et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lysophosphatidic acid (LPA) signaling in vertebrate reproduction

(2009) Xiaoqin Ye et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions

(2008) Tae Nakasaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Roles of lysophosphatidic acid in cardiovascular physiology and disease

(2008) S SMYTH   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Biological roles of lysophospholipid receptors revealed by genetic null mice: An update

(2008) J CHOI   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulation of the LPA2 receptor signaling through the carboxyl-terminal tail-mediated protein–protein interactions

(2008) F LIN   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autotaxin (ATX): A multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties

(2008) L YUELLING   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

LPA and its Analogs-Attractive Tools for Elucidation of LPA Biology and Drug Development

(2008) Kuniyuki Kano et al.   CURRENT MEDICINAL CHEMISTRY

Expression patterns of the lysophospholipid receptor genes during mouse early development

(2008) Hideyo Ohuchi et al.   DEVELOPMENTAL DYNAMICS

Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in theP2RY5gene

(2008) Yutaka Shimomura et al.   EXPERIMENTAL DERMATOLOGY

Subtype-specific Residues Involved in Ligand Activation of the Endothelial Differentiation Gene Family Lysophosphatidic Acid Receptors

(2008) William J. Valentine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine and Human Autotaxin α, β, and γ Isoforms

(2008) Adeline Giganti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid phosphate phosphatases and signaling

(2008) David N. Brindley et al.   JOURNAL OF LIPID RESEARCH

Role of LPA4/p2y9/GPR23 in Negative Regulation of Cell Motility

(2008) Zendra Lee et al.   MOLECULAR BIOLOGY OF THE CELL

G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

(2008) Sandra M Pasternack et al.   NATURE GENETICS

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Measurement of plasma lysophosphatidic acid concentration in healthy subjects: strong correlation with lysophospholipase D activity

(2008) S. Hosogaya et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Gene expression profiling for the identification of G-protein coupled receptors in human platelets

(2007) Stefan Amisten et al.   THROMBOSIS RESEARCH