Nuclear receptors and pathogenesis of pancreatic cancer

The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of theCyp7a1promoter through physical interaction with COUP-TFII

(2013) Tomoko Yamazaki et al.   BIOCHEMICAL JOURNAL

Chronic pancreatitis: A path to pancreatic cancer

(2013) Andreia V. Pinho et al.   CANCER LETTERS

Differential gene expression of the key signalling pathway in para-carcinoma, carcinoma and relapse human pancreatic cancer

(2013) Zheng-Yan Chang et al.   CELL BIOCHEMISTRY AND FUNCTION

Nr5a2heterozygosity sensitises to, and cooperates with, inflammation inKRasG12V-driven pancreatic tumourigenesis

(2013) Marta Flandez et al.   GUT

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

(2013) Guido von Figura et al.   GUT

The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ

(2013) Hang-zi Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

COUP-TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression

(2013) Simone Polvani et al.   INTERNATIONAL JOURNAL OF CANCER

Structure-based Discovery of Antagonists of Nuclear Receptor LRH-1

(2013) Cindy Benod et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Peroxisome Proliferator-Activated Receptorβ/δand B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells

(2013) Jeffrey D. Coleman et al.   PPAR Research

Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3′-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells

(2012) Xi Li et al.   BIOCHEMICAL PHARMACOLOGY

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer

(2012) Donghui Li et al.   CARCINOGENESIS

MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1

(2012) Satyanarayana Rachagani et al.   CARCINOGENESIS

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy

(2012) Satyanarayana Rachagani et al.   Journal of Hematology & Oncology

Therapeutic potential of Liver Receptor Homolog-1 modulators

(2012) Kyren A. Lazarus et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

An emerging role for retinoid X receptor α in malignant hematopoiesis

(2012) Mariam Thomas et al.   LEUKEMIA RESEARCH

Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway

(2012) L Adesso et al.   ONCOGENE

Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and human

(2012) Kyoko Kojima et al.   PROTEOMICS

A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4

(2012) Kyung-Won Min et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Correlations among PPAR, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer

(2012) Valerio Pazienza et al.   PPAR Research

Time-Qualified Patterns of Variation of PPARγ, DNMT1, and DNMT3B Expression in Pancreatic Cancer Cell Lines

(2012) Valerio Pazienza et al.   PPAR Research

PPAR and Oxidative Stress: Con() Catenating NRF2 and FOXO

(2012) Simone Polvani et al.   PPAR Research

PPARs and angiogenesis: Figure 1

(2011) David Bishop-Bailey   BIOCHEMICAL SOCIETY TRANSACTIONS

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells

(2011) Giovanni Vitale et al.   BIOTECHNOLOGY ADVANCES

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Body Mass Index and Obesity- and Diabetes-Associated Genotypes and Risk for Pancreatic Cancer

(2011) H. Tang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors

(2011) Kyungsil Yoon et al.   CARCINOGENESIS

Markers of Pancreatic Cancer: Working Toward Early Detection

(2011) M. Goggins   CLINICAL CANCER RESEARCH

Genetic and Epigenetic Alterations in Pancreatic Carcinogenesis

(2011) Yannick Delpu et al.   CURRENT GENOMICS

Coup d'Etat: An Orphan Takes Control

(2011) Fu-Jung Lin et al.   ENDOCRINE REVIEWS

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function

(2011) S. R. Holmstrom et al.   GENES & DEVELOPMENT

Genome profiling of pancreatic adenocarcinoma

(2011) David J. Birnbaum et al.   GENES CHROMOSOMES & CANCER

PPARγ potentiates anticancer effects of gemcitabine on human pancreatic cancer cells

(2011) Hironori Koga   INTERNATIONAL JOURNAL OF ONCOLOGY

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Cystic Lesions of the Pancreas: Changes in the Presentation and Management of 1,424 Patients at a Single Institution over a 15-Year Time Period

(2011) Sébastien Gaujoux et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Cystic precursors to invasive pancreatic cancer

(2011) Hanno Matthaei et al.   Nature Reviews Gastroenterology & Hepatology

Pancreatic Cancer Susceptibility Loci and Their Role in Survival

(2011) Cosmeri Rizzato et al.   PLoS One

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation

(2011) C. Benod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complexities of obesity and diabetes with the development and progression of pancreatic cancer

(2010) Bin Bao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

(2010) S.-O. Lee et al.   CANCER RESEARCH

Inhibition of peroxisome proliferator-activated receptor γ activity suppresses pancreatic cancer cell motility

(2010) Atsushi Nakajima et al.   CANCER SCIENCE

A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation

(2010) Alessandro Rosa et al.   EMBO JOURNAL

MCC-555-induced NAG-1 expression is mediated in part by KLF4

(2010) Maria Cekanova et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus-transgenic mice by peroxisome proliferator-activated receptor γ-independent regulation of nucleophosmin

(2010) Andrea Galli et al.   HEPATOLOGY

What are nuclear receptor ligands?

(2010) Frances M. Sladek   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

(2010) Gloria M Petersen et al.   NATURE GENETICS

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Peroxisome proliferator-activated receptor γ-dependent activity of indole ring-substituted 1,1-bis(3′-indolyl)-1-(p-biphenyl)methanes in cancer cells

(2009) Jingjing Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Randomized Double-Blind Phase II Trial Comparing Gemcitabine Plus LY293111 Versus Gemcitabine Plus Placebo in Advanced Adenocarcinoma of the Pancreas

(2009) Muhammad Wasif Saif et al.   CANCER JOURNAL

Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling

(2009) Seiko Hirono et al.   CANCER SCIENCE

A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental Contaminants

(2009) Kathryn Z. Guyton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor-Induced B  (Nur77) in Pancreatic Cancer Cells

(2009) S.-O. Lee et al.   MOLECULAR CANCER RESEARCH

Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative

(2009) Indira Jutooru et al.   MOLECULAR CARCINOGENESIS

Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor γ involves angiogenesis inhibition

(2009) Yu-Wei Dong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Role of PPAR Receptors and Leukotriene Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer

(2009) Thomas E. Adrian et al.   PPAR Research

Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease

(2009) Tommaso Mello et al.   PPAR Research

Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor γ synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells

(2008) Wei-Hao Sun et al.   CANCER LETTERS

Nuclear receptor drug discovery

(2008) Taosheng Chen   CURRENT OPINION IN CHEMICAL BIOLOGY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated Receptor

(2008) Schoen W Kruse et al.   PLOS BIOLOGY

Peroxisome Proliferator-Activated Receptor-α Regulates the Expression of Pancreatic/Duodenal Homeobox-1 in Rat Insulinoma (INS-1) Cells and Ameliorates Glucose-Induced Insulin Secretion Impaired by Palmitate

(2007) Ying Sun et al.   ENDOCRINOLOGY