Structure-based Discovery of Antagonists of Nuclear Receptor LRH-1

Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation

(2012) Jullien Rey et al.   ChemMedChem

Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation

(2012) Paul M Musille et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

(2011) Richard J. Whitby et al.   JOURNAL OF MEDICINAL CHEMISTRY

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

(2011) Jae Man Lee et al.   NATURE

Colon cancer cells produce immunoregulatory glucocorticoids

(2011) D Sidler et al.   ONCOGENE

Structural basis of coactivation of liver receptor homolog-1 by  -catenin

(2011) F. Yumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation

(2011) C. Benod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells

(2010) Paul T. R. Thiruchelvam et al.   BREAST CANCER RESEARCH AND TREATMENT

Biology of Colorectal Cancer

(2010) Muhammad Wasif Saif et al.   CANCER JOURNAL

The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells

(2010) Jian-Chien Dominic Heng et al.   Cell Stem Cell

The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion

(2010) A L Chand et al.   ENDOCRINE-RELATED CANCER

Rapid Context-Dependent Ligand Desolvation in Molecular Docking

(2010) Michael M. Mysinger et al.   Journal of Chemical Information and Modeling

Structure-Based Discovery of A2AAdenosine Receptor Ligands

(2010) Jens Carlsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Colloid Formation by Drugs in Simulated Intestinal Fluid

(2010) Allison K. Doak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flexible ligand docking using conformational ensembles

(2010) David M. Lorber et al.   PROTEIN SCIENCE

Canonical Wnt/β-Catenin Regulation of Liver Receptor Homolog-1 Mediates Pluripotency Gene Expression

(2010) Ryan T. Wagner et al.   STEM CELLS

Automated Docking Screens: A Feasibility Study

(2009) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors

(2008) Charlotte Dubé et al.   CANCER LETTERS

Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors

(2008) Kristin E. D. Coan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1

(2008) E. P. Sablin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA