Targeted siRNA delivery using aptamer-siRNA chimeras and aptamer-conjugated nanoparticles

Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of A10-3.2 aptamer targeted and siRNA-loaded cationic nanobubbles for therapy of prostate cancer

(2018) Meng Wu et al.   DRUG DELIVERY

Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44 expressing murine triple-negative breast cancer model

(2018) Walhan Alshaer et al.   JOURNAL OF CONTROLLED RELEASE

Aptamer-functionalized hybrid nanoparticle for the treatment of breast cancer

(2017) David Powell et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

(2017) Shuaijian Ni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of cell proliferation through an ATP-responsive co-delivery system of doxorubicin and Bcl-2 siRNA

(2017) Jianxu Zhang et al.   International Journal of Nanomedicine

Aptamer-incorporated DNA Holliday junction for the targeted delivery of siRNA

(2017) Eun Hye Jeong et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Dual Tumor-Targeting Nanocarrier System for siRNA Delivery Based on pRNA and Modified Chitosan

(2017) Lin Li et al.   Molecular Therapy-Nucleic Acids

Selection, Characterization and Application of Artificial DNA Aptamer Containing Appended Bases with Sub-nanomolar Affinity for a Salivary Biomarker

(2017) Hirotaka Minagawa et al.   Scientific Reports

Cancer-targeted Nucleic Acid Delivery and Quantum Dot Imaging Using EGF Receptor Aptamer-conjugated Lipid Nanoparticles

(2017) Min Woo Kim et al.   Scientific Reports

A specific aptamer-cell penetrating peptides complex delivered siRNA efficiently and suppressed prostate tumor growthin vivo

(2016) Yanjun Diao et al.   CANCER BIOLOGY & THERAPY

Lipid nanoparticles for targeted siRNA delivery – going from bench to bedside

(2016) Victor Kotelianski et al.   International Journal of Nanomedicine

Multivalent Aptamer-RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug-Resistant Cells

(2016) Hyosook Jeong et al.   MACROMOLECULAR BIOSCIENCE

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Construction of an Aptamer–SiRNA Chimera-Modified Tissue-Engineered Blood Vessel for Cell-Type-Specific Capture and Delivery

(2015) Wen Chen et al.   ACS Nano

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

(2015) Ulrich Lächelt et al.   CHEMICAL REVIEWS

Single-walled carbon nanotubes functionalized with aptamer and piperazine–polyethylenimine derivative for targeted siRNA delivery into breast cancer cells

(2015) Marzieh Mohammadi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells

(2015) A. Gilboa-Geffen et al.   MOLECULAR CANCER THERAPEUTICS

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

(2015) Chao Liang et al.   NATURE MEDICINE

Targeting Cancer Cells Using LNA-Modified Aptamer-siRNA Chimeras

(2015) Nithya Subramanian et al.   Nucleic Acid Therapeutics

EpCAM Aptamer-mediated Survivin Silencing Sensitized Cancer Stem Cells to Doxorubicin in a Breast Cancer Model

(2015) Tao Wang et al.   Theranostics

EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer

(2015) Nithya Subramanian et al.   PLoS One

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

(2014) Liyu Li et al.   BIOMATERIALS

Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras

(2014) Wei-Yun Lai et al.   BIOMATERIALS

Multivalent comb-type aptamer–siRNA conjugates for efficient and selective intracellular delivery

(2014) Hyundong Yoo et al.   CHEMICAL COMMUNICATIONS

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

(2014) Andreas Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery

(2014) Phapanin Charoenphol et al.   MOLECULAR PHARMACEUTICS

Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease Therapy

(2014) Jiehua Zhou et al.   Molecular Therapy-Nucleic Acids

Effect of Polyplex Morphology on Cellular Uptake, Intracellular Trafficking, and Transgene Expression

(2013) Julie Shi et al.   ACS Nano

Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity

(2013) Alexey Berezhnoy et al.   JOURNAL OF CLINICAL INVESTIGATION

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Aptamer-functionalized silver nanoclusters-mediated cell type-specific siRNA delivery and tracking

(2013) Jingjing Li et al.   Chemical Science

A Universal Protein Tag for Delivery of SiRNA-Aptamer Chimeras

(2013) Hong Yan Liu et al.   Scientific Reports

Inhibition of HIV-1 protease expression in T cells owing to DNA aptamer-mediated specific delivery of siRNA

(2012) Qinchang Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic RNA aptamers in clinical trials

(2012) Padma Sundaram et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Aptamers and Their Biological Applications

(2012) Kyung-Mi Song et al.   SENSORS

EpCAM and its potential role in tumor-initiating cells

(2012) Sannia Imrich et al.   Cell Adhesion & Migration

Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition

(2012) Alexey Berezhnoy et al.   Molecular Therapy-Nucleic Acids

An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

(2012) Samantha E Wilner et al.   Molecular Therapy-Nucleic Acids

siRNA-Aptamer Chimeras on Nanoparticles: Preserving Targeting Functionality for Effective Gene Silencing

(2011) Vaishali Bagalkot et al.   ACS Nano

Improving the Stability of Aptamers by Chemical Modification

(2011) R. E. Wang et al.   CURRENT MEDICINAL CHEMISTRY

RNAi medicine for the brain: progresses and challenges

(2011) R. L. Boudreau et al.   HUMAN MOLECULAR GENETICS

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Hybrid Polymeric Nanomaterials for siRNA Delivery and Imaging

(2011) Hyejung Mok et al.   MACROMOLECULAR BIOSCIENCE

Understanding the Dual Nature of CD44 in Breast Cancer Progression

(2011) J. M. V. Louderbough et al.   MOLECULAR CANCER RESEARCH

Rational Truncation of an RNA Aptamer to Prostate-Specific Membrane Antigen Using Computational Structural Modeling

(2011) William M. Rockey et al.   Nucleic Acid Therapeutics

A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma

(2011) Nianxi Zhao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Delivery of siRNA Therapeutics: Barriers and Carriers

(2010) Jie Wang et al.   AAPS Journal

Nanoparticle-Based Delivery System for Application of siRNA In Vivo

(2010) Yan Wang et al.   CURRENT DRUG METABOLISM

Efficient and targeted delivery of siRNA in vivo

(2010) Min Suk Shim et al.   FEBS Journal

Breaking down the barriers: siRNA delivery and endosome escape

(2010) M. Dominska et al.   JOURNAL OF CELL SCIENCE

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting cancer cells with nucleic acid aptamers

(2010) Laura Cerchia et al.   TRENDS IN BIOTECHNOLOGY

Lipid-based systemic delivery of siRNA

(2009) Yu-Cheng Tseng et al.   ADVANCED DRUG DELIVERY REVIEWS

Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape

(2009) Tamaki Endoh et al.   ADVANCED DRUG DELIVERY REVIEWS

The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

(2009) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles

(2009) Gary J. Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Chemical Modification of siRNAs for In Vivo Use

(2008) Mark A. Behlke   OLIGONUCLEOTIDES

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

(2008) S. Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamer-based endocytosis of a lysosomal enzyme

(2008) C.-h. B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanotechnology and aptamers: applications in drug delivery

(2008) Etgar Levy-Nissenbaum et al.   TRENDS IN BIOTECHNOLOGY