Review
Cell Biology
Laleh Pezhman, Abd Tahrani, Myriam Chimen
Summary: Type 2 Diabetes Mellitus is a chronic inflammatory disorder associated with obesity, insulin resistance, and hyperglycemia, with white blood cell accumulation in adipose tissue playing a key role in insulin resistance and beta-cell dysfunction. Therapeutic targeting of leukocyte trafficking may be an effective way to control inflammation, diabetes, and its vascular complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Stav Kozlovski, Ofer Regev, Anita Sapoznikov, Marina Kizner, Hagit Achdout, Ekaterina Petrovich-Kopitman, Jacob Elkahal, Yoseph Addadi, Fernanda Vargas E. Silva Castanheira, Sara W. Feigelson, Paul Kubes, Noam Erez, Natalio Garbi, Ronen Alon
Summary: In this study, the role of ICAM-1 and ICAM-2 in immune responses to influenza infection was investigated in mice. The results showed that lung capillary ICAMs were not essential for the entry of NK and neutrophils into virus-infected lungs. Additionally, ICAM-1 and ICAM-2 had little effect on the recruitment of naive T cells and B lymphocytes in mediastinal lymph nodes, but were critical for humoral immunity and the differentiation of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kun Xiang, Zhiwei Xu, Yu-Qian Hu, Yi-Sheng He, Guo-Cui Wu, Tian-Yu Li, Xue-Rong Wang, Li-Hong Ding, Qin Zhang, Sha-Sha Tao, Dong-Qing Ye, Hai-Feng Pan, De-Guang Wang
Summary: Circadian rhythm plays a crucial role in immune system function, with disruptions to clock genes increasing the risk of autoimmune diseases. Research on synthetic ligands of circadian clock genes may help reduce the susceptibility and severity of autoimmune diseases.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
ChunYan Yuan
Summary: IL-33 is a cytokine that modulates inflammation and immune responses, primarily associated with the development of Th2 immunological responses. It has been shown to be elevated in various autoimmune disorders, suggesting a role in inducing autoimmunity and inflammatory damage. The IL-33/ST2 axis holds promising potential as a therapeutic target for autoimmune disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Michael Trauner, Claudia Daniela Fuchs
Summary: Cholestatic and non-alcoholic fatty liver disease have shared pathophysiological mechanisms that can be targeted for intervention through novel therapeutic concepts. Nuclear receptors play a crucial role in the treatment of these diseases, with high affinity therapeutic ligands being developed for specific or multiple isoforms. In addition, other therapeutic approaches targeting inflammation and fibrosis directly are also available. Combination strategies that target metabolic disturbances, inflammation, and fibrosis may be necessary for successful treatment of these complex disorders.
Review
Immunology
Qi Jiang, Xin Wang, Enyu Huang, Qiao Wang, Chengping Wen, Guocan Yang, Liwei Lu, Dawei Cui
Summary: Inflammasome is a cellular complex involved in the innate inflammatory response, and its excessive or abnormal activation has been implicated in various diseases. In rheumatoid arthritis, inflammasome activation plays a key role in immune dysregulation and joint inflammation. This review summarizes recent research on inflammasome activation and its effector mechanisms in the pathogenesis of rheumatoid arthritis, as well as potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Maria Dema, Herena Eixarch, Luisa M. Villar, Xavier Montalban, Carmen Espejo
Summary: The number of elderly multiple sclerosis patients is increasing due to improved life expectancy and available treatments. Current treatments cannot halt disability accumulation associated with disease progression, potentially due to the impact of immunosenescence, leading to abnormal immune cell subsets contributing to autoimmune disease development. Strategies including senolytics, regenerative therapies, and rejuvenation of immune cells have been proposed to potentially reverse immunosenescence and benefit MS progression.
AUTOIMMUNITY REVIEWS
(2021)
Review
Chemistry, Medicinal
Doha Anka Idrissi, Nezha Senhaji, Asmae Aouiss, Loubna Khalki, Youssef Tijani, Nabil Zaid, Fatima Zahra Marhoume, Abdallah Naya, Mounia Oudghiri, Mostafa Kabine, Younes Zaid
Summary: UC and CD are chronic and multifactorial diseases affecting the intestinal tract, characterized by recurrent inflammation leading to symptoms such as abdominal pain, diarrhea, vomiting, and rectal bleeding. IBD involves defects in the intestinal mucosal barrier in genetically predisposed individuals due to an uncontrolled inflammatory response to normal flora, potentially triggered by environmental factors or specific lifestyle choices. The involvement of the CD40/CD40L platelet complex and IL-1 in the development of IBD, particularly CD, has been extensively studied and may provide insights for future therapeutic approaches targeting these pathways.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Miguel Camba-Gomez, Laura Arosa, Oreste Gualillo, Javier Conde-Aranda
Summary: Despite the benefits of current therapeutic options, there is a need for novel pharmacological targets to improve the treatment of inflammatory bowel disease (IBD). Chemokine and chemokine receptors have emerged as appealing options, as they regulate leukocyte trafficking and other processes related to intestinal inflammation development.
DRUG DISCOVERY TODAY
(2022)
Article
Immunology
Hantao Lou, Guang Sheng Ling, Xuetao Cao
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by organ damage and a wide range of autoantibodies. The mechanisms of tissue damage and inflammation caused by autoantibodies are not fully understood, but studying autoreactive B cells and pathogenic autoantibodies can enhance our understanding of the origins and targets of SLE. Developing specific therapies targeting pathogenic B cell subsets and autoantibodies remains a challenge. Comprehensive autoantibody profiling and functional characterization can provide new insights into the etiology and pathogenesis of SLE.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Mansour Haddad, Federica Cherchi, Mohammad Alsalem, Yousef M. Al-saraireh, Saba Madae'en
Summary: This review presents new findings on the role of adenosine and its receptors in neuropathic and inflammatory pain. Adenosine receptor ligands have shown promising efficacy and safety in clinical research and could be used as therapeutic targets for various pain disorders. The review also discusses the latest studies on adenosine receptor ligands in different pain models and the potential of newly synthesized allosteric adenosine receptor modulators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Maneesha Kunnathattil, Pedapudi Rahul, Tom Skaria
Summary: This article critically reviews the potential of soluble vascular endothelial glycocalyx proteoglycans in modulating pathological inflammatory responses. It discusses the beneficial anti-inflammatory effects of syndecan-1, syndecan-3, and biglycan, as well as the proinflammatory effects of versikine and decorin. It suggests that targeting these soluble proteoglycans may be a potential therapeutic strategy to suppress overstimulated cytokine and leukocyte responses in inflammatory diseases.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Review
Immunology
Swati Sharma, Tarun Tyagi, Silvio Antoniak
Summary: Thrombo-inflammation, characterized by the formation of microvascular thrombosis and inflammation, is a clinical manifestation observed in various diseases. Platelets play a crucial role in this process by contributing to coagulation, inflammatory processes, and leukocyte recruitment. Understanding the role of platelets in thrombo-inflammatory disorders, including COVID-19, can provide valuable insights for potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Mary K. Crow
Summary: Research has identified type I interferon (IFN-I) and autoantibodies targeting nucleic acids and nucleic acid-binding proteins as fundamental contributors to the pathogenesis of systemic lupus erythematosus (SLE). This review summarizes recent genetic analyses of SLE patients and current studies on innate and adaptive immune function, which contribute to sustained IFN-I pathway activation, immune activation, autoantibody production, inflammatory mediator generation, and tissue damage. The goal of these studies is to understand disease mechanisms, identify therapeutic targets, and develop better treatments for patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
Michael P. Czubryt, Taben M. Hale
Summary: Cardiac fibrosis is a characteristic of end-stage heart disease, but there are no approved therapies directly targeting the extracellular matrix. Research on cardiac fibroblasts is hindered by the lack of a clear marker.
CELLULAR SIGNALLING
(2021)
Article
Critical Care Medicine
Claudio Sorio, Alessio Montresor, Matteo Bolomini-Vittori, Sara Caldrer, Barbara Rossi, Silvia Dusi, Stefano Angiari, Jan E. Johansson, Marzia Vezzalini, Teresinha Leal, Elisa Calcaterra, Baroukh M. Assael, Paola Melotti, Carlo Laudanna
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Editorial Material
Cell Biology
Stefano Angiari, Luke A. O'Neill
Article
Biochemistry & Molecular Biology
Richard G. Carroll, Zbigniew Zaslona, Silvia Galvan-Pena, Emma L. Koppe, Daniel C. Sevin, Stefano Angiari, Martha Triantafilou, Kathy Triantafilou, Louise K. Modis, Luke A. O'Neill
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
James O. Early, Deepthi Menon, Cathy A. Wyse, Mariana P. Cervantes-Silva, Zbigniew Zaslona, Richard G. Carroll, Eva M. Palsson-McDermott, Stefano Angiari, Dylan G. Ryan, Sarah E. Corcoran, George Timmons, Sarah S. Geiger, Darren J. Fitzpatrick, Daniel O'Connell, Ramnik J. Xavier, Karsten Hokamp, Luke A. J. O'Neill, Annie M. Curtis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Cell Biology
Rosa C. Paolicelli, Stefano Angiari
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2019)
Article
Cell Biology
Stefano Angiari, Marah C. Runtsch, Caroline E. Sutton, Eva M. Palsson-McDermott, Beth Kelly, Nisha Rana, Harry Kane, Gina Papadopoulou, Erika L. Pearce, Kingston H. G. Mills, Luke A. J. O'Neill
Article
Cell Biology
Mark M. Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Palsson-McDermott, Sinead C. Corr, Kingston H. G. Mills, Roger J. S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board, Luke A. J. O'Neill
Article
Immunology
Silvia Dusi, Stefano Angiari, Enrica Caterina Pietronigro, Nicola Lopez, Gabriele Angelini, Elena Zenaro, Vittorina Della Bianca, Gabriele Tosadori, Francesca Paris, Antonella Amoruso, Tommaso Carlucci, Gabriela Constantin, Barbara Rossi
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Cell Biology
Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark M. Hughes, Alan D. Irvine, Roman Fischer, Luke A. J. O'Neill
Review
Biochemistry & Molecular Biology
Marah C. Runtsch, Giovanni Ferrara, Stefano Angiari
Summary: Neuroinflammatory and neurodegenerative diseases involve the recruitment of circulating immune cells into the central nervous system, which can either perpetuate detrimental responses or dampen inflammation and promote tissue repair. Recent research highlights the role of metabolic reprogramming in regulating immune cell activity and function, with implications for potential therapeutic targeting in neurological disorders.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Hauke J. Weiss, Stefano Angiari
Review
Immunology
Johannes Fessler, Stefano Angiari
Summary: Immunosenescence is a dysregulated state characterized by cell cycle arrest, telomere shortening, cellular stress markers expression, and pro-inflammatory mediators secretion. This process mainly occurs during aging, but can also be induced in other pathological conditions. Senescent immune cells may contribute to chronic inflammation and tissue damage, particularly in neurological diseases such as multiple sclerosis and Alzheimer's disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, Maria A. Argiriadi, Anne F. McGettrick, Rui Santalla Mendez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayamaran, Kamal Dua, Alexandra C. Brown, Richard Y. Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke A. J. O'Neill
Summary: Itaconate and 4-octyl itaconate inhibit M2 macrophage polarization and metabolic remodeling by suppressing JAK1 phosphorylation and kinase activity. This discovery provides a new strategy to inhibit JAK1 in M2 macrophage-driven diseases.
Editorial Material
Behavioral Sciences
Stefano Angiari, Giuseppina D'Alessandro, Rosa Chiara Paolicelli, Ilaria Prada, Eleonora Vannini
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
