Review
Immunology
Animesh Sarker, Nidhi Dhama, Rinkoo Devi Gupta
Summary: Dengue is a common viral infection transmitted by mosquitoes in tropical countries. While the initial infection is usually mild, secondary infections can be severe and potentially fatal. The antibodies produced in response to vaccination or primary infection are often weakly neutralizing and can increase the risk of antibody-dependent enhancement (ADE) during subsequent infections.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hong-Jyun Huang, Martyr Yang, Hsin-Wei Chen, Shuying Wang, Chih-Peng Chang, Tzong-Shiann Ho, Yu-San Kao, Sen-Mao Tien, Hsing-Han Lin, Po-Chun Chang, Yen-Chung Lai, Yu-Peng Hsiao, Yi-Ling Liu, Chiao-Hsuan Chao, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin, Shu-Wen Wan
Summary: This study developed a modified DENV vaccine candidate with enhanced features by combining modifications of two DENV proteins. The vaccine candidate showed protective effects against DENV infection in a mouse model, indicating its potential clinical application.
Article
Immunology
Noe Juvenal Mendoza-Ramirez, Julio Garcia-Cordero, Sandra Paola Martinez-Frias, Daniela Roa-Velazquez, Rosendo Luria-Perez, Jose Bustos-Arriaga, Jesus Hernandez-Lopez, Carlos Cabello-Gutierrez, Joaquin Alejandro Zuniga-Ramos, Edgar Morales-Rios, Sonia Mayra Perez-Tapia, Martha Espinosa-Cantellano, Leticia Cedillo-Barron
Summary: This study analyzes the combination of two SARS-CoV-2 viral antigens and finds that immunization with a combination of S1 or RBD and the N protein can elicit a stronger immune response. The sera from immunized mice can recognize different variants of SARS-CoV-2. This study identifies potential antigens for the second generation of COVID-19 vaccines.
Article
Microbiology
Guntur Fibriansah, Elisa X. Y. Lim, Jan K. Marzinek, Thiam-Seng Ng, Joanne L. Tan, Roland G. Huber, Xin-Ni Lim, Valerie S. Y. Chew, Victor A. Kostyuchenko, Jian Shi, Ganesh S. Anand, Peter J. Bond, James E. Crowe, Shee-Mei Lok
Summary: Dengue virus has four serotypes (DENV1-4) with different strains within each serotype. The virus can exhibit smooth or bumpy surface morphologies at 37 degrees C, depending on the strain. High-affinity therapeutic antibodies are able to neutralize diverse morphologies of dengue virus.
Article
Immunology
Rebecca Weiss, Leila Issmail, Alexandra Rockstroh, Thomas Grunwald, Jasmin Fertey, Sebastian Ulbert
Summary: West Nile Virus is a virus transmitted by mosquitoes that can cause severe neurological symptoms. However, there is currently no human vaccine available for WNV. This study found that the E protein and the fusion loop domain (FL) of WNV have cross-reactivity, which should be taken into consideration for vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Te-Sheng Lien, Der-Shan Sun, Shih-Che Hung, Wen-Sheng Wu, Hsin-Hou Chang
Summary: The study shows that the dengue virus envelope protein domain III can induce neutrophil NETosis processes, and inhibition of Nlrp3 inflammasome can suppress this process, providing a new molecular target for treating dengue-induced inflammatory pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Kum-Kang So, Jeesun Chun, Nguyen Ngoc Luong, Hee-Won Seo, Dae-Hyuk Kim
Summary: The study demonstrated the efficient production of various immunocomplex structures of the target protein in Saccharomyces cerevisiae for future development of oral and injectable vaccines against pathogens.
BIOTECHNOLOGY LETTERS
(2021)
Article
Chemistry, Medicinal
Alexander J. Badten, Aaron Ramirez, Jenny E. Hernandez-Davies, Tyler J. Albin, Aarti Jain, Rie Nakajima, Jiin Felgner, D. Huw Davies, Szu-Wen Wang
Summary: The majority of seasonal influenza vaccines are currently produced using eggs, but a recombinant nanoparticle-based approach could improve their immunogenicity, durability, and response. In this study, researchers coupled the H1N1 influenza virus hemagglutinin protein to the E2 nanoparticle and found that it induced a balanced Th1/Th2 immune response. Adding the Toll-like receptor 4 agonist MPLA enhanced the immunogenicity and cross-reactivity of the conjugated H1-E2. This study demonstrates the potential of nanotechnology for developing more effective influenza vaccines.
ACS INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Min-Chia Wu, Yi-Ting Lo, Hsing-Chieh Wu, Hsian-Yu Wang, Chun-Yen Chu
Summary: The study expressed different fragments of recombinant PMT proteins, combined with a water-in-oil-in-water adjuvant, and evaluated mice's immune response. The rPMT-C-immunized group showed significantly higher levels of IgG, IgG2a antibody, interferon-gamma, and IL-12 cytokine expression than other groups. Vaccination with rPMT-C recombinant protein can provide homologous and heterologous protection against P. multocida challenge.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Flavia Chiuppesi, John A. Zaia, Katelyn Faircloth, Daisy Johnson, Minh Ly, Veronica Karpinski, Corinna La Rosa, Jennifer Drake, Joan Marcia, Ann Marie Acosta, Shannon Dempsey, Randy A. Taplitz, Qiao Zhou, Yoonsuh Park, Sandra Ortega Francisco, Teodora Kaltcheva, Paul H. Frankel, Steven Rosen, Felix Wussow, Sanjeet Dadwal, Don J. Diamond
Summary: Individuals vaccinated with COH04S1 or mRNA vaccine BNT162b2 maintain robust cross-reactive cellular immunity for six or more months post-vaccination, providing long-term protection against both ancestral and variant strains of SARS-CoV-2.
Review
Microbiology
Helton C. Santiago, Tertuliano A. Pereira-Neto, Marcela H. Goncalves-Pereira, Ana C. B. Terzian, Anna P. Durbin
Summary: This article discusses the development of a Zika virus vaccine, with a focus on the immunological relationship between Zika virus and dengue virus, as well as the challenges posed by the low numbers of Zika virus infections and the use of a controlled human infection model to accelerate vaccine development.
Article
Immunology
Te-Sheng Lien, Der-Shan Sun, Cheng-Yeu Wu, Hsin-Hou Chang
Summary: The study found that endothelial cell death plays an important role in dengue hemorrhagic fever, and this death can be attenuated by inhibiting the Nlrp3 inflammasome. The results suggest that the Nlrp3 inflammasome may be a potential therapeutic target for treating DHF.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jue Hou, Weijian Ye, Jianzhu Chen
Summary: Dengue is a common mosquito-borne disease caused by four closely related viruses. Developing a vaccine that can protect against all four virus strains without adverse effects is a challenge. Several tetravalent live attenuated vaccine candidates have entered clinical trials.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Te-Sheng Lien, Hao Chan, Der-Shan Sun, Jhen-Cheng Wu, You-Yen Lin, Guan-Ling Lin, Hsin-Hou Chang
Summary: The study suggests that EIII could be considered as a virulence factor of DENV, and that Nlrp3 inflammasome is a feasible target for developing therapeutic approaches against dengue-induced platelet defects. Blockages of EIII-induced platelet signaling using inhibitors markedly ameliorated DENV- and EIII-induced thrombocytopenia, platelet activation, and cell death.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Leandro Nunez-Munoz, Gabriel Marcelino-Perez, Berenice Calderon-Perez, Miriam Perez-Saldivar, Karla Acosta-Virgen, Hugo Gonzalez-Conchillos, Brenda Vargas-Hernandez, Ana Olivares-Martinez, Roberto Ruiz-Medrano, Daniela Roa-Velazquez, Edgar Morales-Rios, Jorge Ramos-Flores, Gustavo Torres-Franco, Diana Pelaez-Gonzalez, Jorge Fernandez-Hernandez, Martha Espinosa-Cantellano, Diana Tapia-Sidas, Jose Abrahan Ramirez-Pool, America Padilla-Viveros, Beatriz Xoconostle-Cazares
Summary: This study demonstrated the potential usefulness of antigens based on the non-N-glycosylated region of RBD from SARS-CoV-2 by expressing and testing potential antigens NG06 and NG19 in different animal models to induce immune responses.
Article
Virology
Mohamed S. H. Hassan, Ahmed Ali, Motamed Elsayed Mahmoud, Danah Altakrouni, Shahnas M. Najimudeen, Mohamed Faizal Abdul-Careem
Summary: This study compared the efficacy of different vaccination programs against Canadian DMV/1639 IBV and found that the autogenous inactivated DMV/1639 vaccine was more effective in reducing viral loads and boosting virus neutralization titers. Both vaccination programs provided significant protection against pathological effects.
Article
Virology
Wanda Christ, Jonas Klingstrom, Janne Tynell
Summary: The integrated stress response (ISR) is activated in response to SARS-CoV-2 infection, triggering translational arrest and inhibiting stress granule formation. However, the stress-responsive transcription factors ATF4 and CHOP are not induced. Different SARS-CoV-2 variants show variant-specific differences in ISR activation, suggesting potential impacts on pathogenesis and treatment strategies.
Article
Virology
Xiao Han, Hankun Xu, Yifan Weng, Rong Chen, Jidong Xu, Tong Cao, Renjie Sun, Ying Shan, Fang He, Weihuan Fang, Xiaoliang Li
Summary: Classical swine fever virus (CSFV) can inhibit the host innate immunity by decreasing the level of high mobility group box 1 (HMGB1), and CSFV Npro can evade host antiviral immune response through upregulating HMGB1 acetylation.
Article
Virology
Sunjian Lyu, Fulei Xiong, Tianpeng Qi, Weifeng Shen, Qi Guo, Mingming Han, Li Liu, Weishao Bu, Julin Yuan, Bao Lou
Summary: This study identified and characterized a novel temperate A. hydrophila phage, P05B, which has strong lytic ability and stability across different temperatures and pH values.
Article
Virology
Siyuan Liu, Wei Chen, Raphael Nyaruaba, Shunlong Wang, Cihan Yang, Qun Wu, Ying Liu, Puyu Liu, Fei Wang, Jingling Wang, Zhiming Yuan, Dingwei Sun, Han Xia
Summary: Specific, sensitive, and reliable RT-qPCR assays for the detection of OYAV and EBIV have been successfully developed in this study. These assays hold great promise for their potential application in clinical and field samples in the future.
Article
Virology
Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang
Summary: Coxsackievirus A6 (CVA6) has emerged as an important agent causing hand, foot, and mouth disease (HFMD). Mutations in residue 64 of the virus have been found to increase resistance to ribavirin and decrease sensitivity to guanidine hydrochloride. This mutation also leads to increased replication fidelity and reduced pathogenicity. These findings provide a foundation for the development of a safe and effective live attenuated CVA6 vaccine.
Article
Virology
Yao Xiong, Keran Ma, Xiao Zou, Yantao Liang, Kaiyang Zheng, Tiancong Wang, Hong Zhang, Yue Dong, Ziyue Wang, Yundan Liu, Hongbing Shao, Andrew Mcminn, Min Wang
Summary: This study isolated a novel virus, vB_VviC_ZQ26, infecting Vibrio cyclitrophicus from coastal waters near Qingdao, China. It was found that vB_VviC_ZQ26 belongs to a new vibriophage-specific family, Coheviridae, and is mainly found in temperate and tropical epipelagic zones.
Article
Virology
Xing Li, Zhiping Ye, Ewan P. Plant
Summary: By analyzing clinical and cultured samples using the same bioinformatic pipeline, it was found that 5' copyback DVGs are prevalent in human clinical samples but not in cultured samples. Furthermore, there are differences in DVG production and composition between in vivo and in vitro infections.
Article
Virology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar
Summary: Rotavirus is a major cause of viral gastroenteritis in infants and continues to be a severe issue in underdeveloped nations. Recent research has shown that a long non-coding RNA called SLC7A11-AS1 is upregulated during rotavirus infection and plays a role in facilitating the virus's propagation by regulating intracellular glutathione and lipid peroxidation.
Article
Virology
Eiichi Hondo, Tetsufumi Katta, Ayato Sato, Naoya Kadofusa, Tomoki Ishibashi, Hiroshi Shimoda, Hirokazu Katoh, Atsuo Iida
Summary: Bat-borne emerging viruses, such as the Ebola virus and Nipah virus, pose a significant threat to public health. In this study, we identified micafungin as a potential antiviral drug against Pteropine orthoreovirus (PRV) and found that it inhibits viral release in human cells through activating the endoplasmic reticulum stress response pathway. This research provides valuable insights into the development of effective treatments for future virus pandemics.
Article
Virology
M. Joubert, N. van den Berg, J. Theron, V. Swart
Summary: This study investigated the host gene expression in asymptomatic avocado nursery trees infected with Avocado sunblotch viroid (ASBVd) using RNA sequencing. The results showed that 631 genes were differentially expressed during infection, with 63% upregulated. ASBVd infection significantly affected plant defence responses, phytohormone networks, gene expression pathways, secondary metabolism, cellular transport, as well as protein modification and degradation. This study provides insights into the molecular interactions underlying avsunviroid-host interactions.
Article
Virology
Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wang
Summary: EV71 infection leads to changes in mitochondrial morphology and dynamics in human neuroblastoma cells, resulting in mitochondrial dysfunction that may contribute to nervous system dysfunction.
Article
Virology
Mikhail Oliveira Leastro, Elliot Watanabe Kitajima, Vicente Pallas, Jesus Angel Sanchez- Navarro
Summary: This study reports the construction and validation of an infectious cDNA clone of Citrus leprosis virus C (CiLV-C) based on an agroinfection system. Agro-injected Nicotiana benthamiana plants showed localized lesions similar to the natural infection process. The virus recovered from the infected plant tissue could be mechanically transmitted between plants. The CiLV-C reverse genetic system provides a powerful molecular tool for unraveling the peculiarities of the citrus leprosis pathosystem.
Article
Virology
Manel Essaidi-Laziosi, Francisco J. Perez-Rodriguez, Catia Alvarez, Pascale Sattonnet-Roche, Giulia Torriani, Meriem Bekliz, Kenneth Adea, Matthias Lenk, Tasnim Suliman, Wolfgang Preiser, Marcel A. Mueller, Christian Drosten, Laurent Kaiser, Isabella Eckerle
Summary: This study found that the Omicron variant has different replication characteristics compared to other variants of concern, being able to efficiently produce infectious virus in nasal cells but not lung cells. In addition, the Delta and Omicron variants showed increased infection efficiency in A549 cells. These findings suggest that the variants of concern have better adaptation to humans but do not have an extended host range.
Article
Virology
Martin Faye, Modeste Name Faye, Babacar Ndiaye, Moussa Moise Diagne, Safietou Sankhe, Ndeye Marieme Top, Amadou Diallo, Cheikh Loucoubar, Ndongo Dia, Amadou Alpha Sall, Ousmane Faye
Summary: Genomic surveillance in Senegal since March 2020 has detected the emergence of Omicron BA.4 and BA.5 sublineages in June 2022. Next-generation sequencing and phylogeny analysis of isolates from a cluster of cases in Northern Senegal in July 2022 revealed that the BA.4 cases originated from a XAS recombinant, marking the first reported sequence of this variant from Senegal. Continuous genomic surveillance of positive SARS-CoV-2 samples is crucial.