期刊
VIRUS RESEARCH
卷 138, 期 1-2, 页码 135-138出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2008.08.008
关键词
Dengue; Cross-reactivity; Recombinant protein; Vaccine; P64k; Domain III
类别
资金
- Cuban Program for Dengue Vaccine Development
Here, the antigenic specificity of the recombinant fusion proteins containing aa 286-426 of the dengue envelope protein fused to P64k from Neisseria meningitidis and the cross-reactive antibody response induced in immunized mice and monkeys were evaluated. The anti-dengue mice antibodies showed a higher reactivity to the homologous recombinant proteins compared to the wide cross-reactivity observed by dot blot to the viral antigens. The immune response induced by the recombinant proteins in mice and monkeys, was highly serotype specific. The serotype-specificity associated with these recombinant proteins in addition to the high antigenicity, immunogenicity and protecting capacity Suggest their advantages as possible vaccine candidates. (C) 2008 Elsevier B.V. All rights reserved.
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