Peculiarities of Zika Immunity and Vaccine Development: Lessons from Dengue and the Contribution from Controlled Human Infection Model

A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans

(2021) Usha K. Nivarthi et al.   Nature Communications

Zika vaccines: can we solve one problem without creating another one?

(2021) Priscila M S Castanha et al.   LANCET INFECTIOUS DISEASES

High Incidence of Zika or Chikungunya Infection among Pregnant Women Hospitalized Due to Obstetrical Complications in Northeastern Brazil—Implications for Laboratory Screening in Arbovirus Endemic Area

(2021) Iracema J. A. A. Jacques et al.   Viruses-Basel

Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil

(2021) Ricardo Arraes de Alencar Ximenes et al.   PLoS Neglected Tropical Diseases

Type 1 Innate Lymphoid Cell and Natural Killer Cells Are Sources of Interferon-γ and Other Inflammatory Cytokines Associated With Distinct Clinical Presentation in Early Dengue Infection

(2021) Iracema Luisa Quintino-de-Carvalho et al.   JOURNAL OF INFECTIOUS DISEASES

Mother-to-Child Transmission of Arboviruses during Breastfeeding: From Epidemiology to Cellular Mechanisms

(2021) Sophie Desgraupes et al.   Viruses-Basel

A Zika Endemic Model for the Contribution of Multiple Transmission Routes

(2021) Xiaoyan Yuan et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Yellow fever vaccine protects mice against Zika virus infection

(2021) Ana C. Vicente Santos et al.   PLoS Neglected Tropical Diseases

T cells producing multiple combinations of IFNγ, TNF and IL10 are associated with mild forms of dengue infection

(2020) Marcela Helena Gonçalves Pereira et al.   IMMUNOLOGY

Multifunctional T cell response in convalescent patients two years after ZIKV infection

(2020) Tertuliano Alves Pereira Neto et al.   JOURNAL OF LEUKOCYTE BIOLOGY

RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death

(2020) Mirjam Schilling et al.   Cells

Ethical issues surrounding controlled human infection challenge studies in endemic low‐and middle‐income countries

(2020) Euzebiusz Jamrozik et al.   BIOETHICS

Zika virus infection enhances future risk of severe dengue disease

(2020) Leah C. Katzelnick et al.   SCIENCE

Cross-serotypically conserved epitope recommendations for a universal T cell-based dengue vaccine

(2020) Syed Faraz Ahmed et al.   PLoS Neglected Tropical Diseases

Seroprevalence, spatial dispersion and factors associated with flavivirus and chikungunya infection in a risk area: a population-based seroprevalence study in Brazil

(2020) Francisca Kalline de Almeida Barreto et al.   BMC INFECTIOUS DISEASES

Congenital Zika syndrome: A systematic review

(2020) Danielle A. Freitas et al.   PLoS One

A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development

(2020) Priscila M. S. Castanha et al.   Viruses-Basel

Maternal immunity and antibodies to dengue virus promote infection and Zika virus–induced microcephaly in fetuses

(2019) Abhay P. S. Rathore et al.   Science Advances

Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

(2019) Moritz U. G. Kraemer et al.   Nature Microbiology

CD4+ T cells promote humoral immunity and viral control during Zika virus infection

(2019) Annie Elong Ngono et al.   PLoS Pathogens

Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil

(2019) Priscila M. S. Castanha et al.   PLoS Neglected Tropical Diseases

Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika

(2019) Paulina Andrade et al.   Nature Communications

Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

(2019) Isabel Rodriguez-Barraquer et al.   SCIENCE

Zika virus antagonizes interferon response in patients and disrupts RIG-I–MAVS interaction through its CARD-TM domains

(2019) Yiwen Hu et al.   Cell and Bioscience

A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III

(2019) Dan Hu et al.   PLoS Pathogens

Identification of Protective CD8 T Cell Responses in a Mouse Model of Zika Virus Infection

(2019) Mariah Hassert et al.   Frontiers in Immunology

Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

(2019) Natasha D Durham et al.   eLife

Immune Response to Dengue and Zika

(2018) Annie Elong Ngono et al.   Annual Review of Immunology

Guillain–Barré syndrome risk among individuals infected with Zika virus: a multi-country assessment

(2018) Luis Mier-y-Teran-Romero et al.   BMC Medicine

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling

(2018) Jonny Hertzog et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sustained Specific and Cross-Reactive T Cell Responses to Zika and Dengue Virus NS3 in West Africa

(2018) Bobby Brooke Herrera et al.   JOURNAL OF VIROLOGY

Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage

(2018) Felipe Gomes Naveca et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

(2018) Saranya Sridhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses

(2018) C. J. Reynolds et al.   Scientific Reports

RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes

(2018) Maxime Chazal et al.   Cell Reports

Clinical Features of Guillain-Barré Syndrome With vs Without Zika Virus Infection, Puerto Rico, 2016

(2018) Emilio Dirlikov et al.   JAMA Neurology

Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus

(2018) Hong-Yan Guo et al.   Journal of Immunology Research

Dengue immune sera enhance Zika virus infection in human peripheral blood monocytes through Fc gamma receptors

(2018) Min Li et al.   PLoS One

Steep drop in Zika cases undermines vaccine trial

(2018) Jon Cohen   SCIENCE

Improved Immune Responses Against Zika Virus After Sequential Dengue and Zika Virus Infection in Humans

(2018) Félix Delgado et al.   Viruses-Basel

T Cell Responses to Nonstructural Protein 3 Distinguish Infections by Dengue and Zika Viruses

(2018) Bobby Brooke Herrera et al.   mBio

Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy

(2018) Jose Angel Regla-Nava et al.   Nature Communications

CD4+T cells mediate protection against Zika associated severe disease in a mouse model of infection

(2018) Mariah Hassert et al.   PLoS Pathogens

Neutralizing Antibody Correlates Analysis of Tetravalent Dengue Vaccine Efficacy Trials in Asia and Latin America

(2017) Zoe Moodie et al.   JOURNAL OF INFECTIOUS DISEASES

Replication and Excretion of the Live Attenuated Tetravalent Dengue Vaccine CYD-TDV in a Flavivirus-Naive Adult Population: Assessment of Vaccine Viremia and Virus Shedding

(2017) Joseph Torresi et al.   JOURNAL OF INFECTIOUS DISEASES

Prospects for induction of CD8 T cell-mediated immunity to Zika virus infection by yellow fever virus vaccination

(2017) K. Blom et al.   JOURNAL OF INTERNAL MEDICINE

Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans

(2017) Alba Grifoni et al.   JOURNAL OF VIROLOGY

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

(2017) Susana V. Bardina et al.   SCIENCE

High Zika Virus Seroprevalence in Salvador, Northeastern Brazil Limits the Potential for Further Outbreaks

(2017) Eduardo Martins Netto et al.   mBio

Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

(2017) Jinsheng Wen et al.   Nature Communications

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

(2017) Petraleigh Pantoja et al.   Nature Communications

Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques

(2017) Michael K. McCracken et al.   PLoS Pathogens

Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro

(2017) Yaoxing Wu et al.   Cell Discovery

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

A Mouse Model of Zika Virus Pathogenesis

(2016) Helen M. Lazear et al.   Cell Host & Microbe

Zika virus inhibits type‐I interferon production and downstream signaling

(2016) Anil Kumar et al.   EMBO REPORTS

Zika virus complete genome from Salvador, Bahia, Brazil

(2016) Marta Giovanetti et al.   INFECTION GENETICS AND EVOLUTION

Dissecting antibodies induced by a chimeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) in naïve and dengue exposed individuals

(2016) Sandra Henein et al.   JOURNAL OF INFECTIOUS DISEASES

Dengue virus (DENV)-specific antibodies enhance Brazilian Zika virus (ZIKV) infection

(2016) Priscila MS Castanha et al.   JOURNAL OF INFECTIOUS DISEASES

Association between Guillain-Barré syndrome and Zika virus infection

(2016) Leonelo E Bautista et al.   LANCET

Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study

(2016) Guilherme Calvet et al.   LANCET INFECTIOUS DISEASES

Structural basis of potent Zika–dengue virus antibody cross-neutralization

(2016) Giovanna Barba-Spaeth et al.   NATURE

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

(2016) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

Zika Virus Infection in Pregnant Women in Rio de Janeiro

(2016) Patrícia Brasil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus

(2016) Lyle R. Petersen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

(2016) Lalita Priyamvada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zika virus in the Americas: Early epidemiological and genetic findings

(2016) N. R. Faria et al.   SCIENCE

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

(2016) K. Stettler et al.   SCIENCE

Dengue Antibody and Zika: Friend or Foe?

(2016) Anna P. Durbin   TRENDS IN IMMUNOLOGY

Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?

(2016) A. S. Oliveira Melo et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Meeting Report: WHO consultation on considerations for regulatory expectations of Zika virus vaccines for use during an emergency

(2016) K.S. Vannice et al.   VACCINE

Zika virus infection, associated microcephaly, and low yellow fever vaccination coverage in Brazil: is there any causal link?

(2016) Luciano Pamplona De Góes Cavalcanti et al.   Journal of Infection in Developing Countries

Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015

(2016) Lavinia Schuler-Faccini et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015

(2016) Wanderson Kleber de Oliveira et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

How antibodies alter the cell entry pathway of dengue virus particles in macrophages

(2016) Nilda V. Ayala-Nunez et al.   Scientific Reports

Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control

(2015) Michael S. Diamond et al.   CELL

Human CD8+T-Cell Responses Against the 4 Dengue Virus Serotypes Are Associated With Distinct Patterns of Protein Targets

(2015) Daniela Weiskopf et al.   JOURNAL OF INFECTIOUS DISEASES

Biology of Zika Virus Infection in Human Skin Cells

(2015) Rodolphe Hamel et al.   JOURNAL OF VIROLOGY

Dengue vaccine: hypotheses to understand CYD-TDV-induced protection

(2015) Bruno Guy et al.   NATURE REVIEWS MICROBIOLOGY

Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease

(2015) Sri Rezeki Hadinegoro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America

(2015) Luis Villar et al.   NEW ENGLAND JOURNAL OF MEDICINE

How RIG-I like receptors activate MAVS

(2015) Bin Wu et al.   Current Opinion in Virology

Rapid spread of emerging Zika virus in the Pacific area

(2014) D. Musso et al.   CLINICAL MICROBIOLOGY AND INFECTION

Zika virus infection complicated by Guillain-Barré syndrome – case report, French Polynesia, December 2013

(2014) E Oehler et al.   Eurosurveillance

Assessment of bivalent and tetravalent dengue vaccine formulations in flavivirus-naïve adults in Mexico

(2014) Gustavo H Dayan et al.   Human Vaccines & Immunotherapeutics

Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D As It Matures from an Effector- to a Memory-Type Response

(2013) K. Blom et al.   JOURNAL OF IMMUNOLOGY

Persistence of Th1/Tc1 responses one year after tetravalent dengue vaccination in adults and adolescents in Singapore

(2013) Anke Harenberg et al.   Human Vaccines & Immunotherapeutics

Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial

(2012) Arunee Sabchareon et al.   LANCET

Intracellular Cytokine Production by Dengue Virus–specific T cells Correlates with Subclinical Secondary Infection

(2011) Steven Hatch et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody-mediated neutralization of flaviviruses: A reductionist view

(2011) Kimberly A. Dowd et al.   VIROLOGY

STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon Receptor

(2011) Stuart T. Perry et al.   PLoS Pathogens

Mouse STAT2 Restricts Early Dengue Virus Replication

(2010) Joseph Ashour et al.   Cell Host & Microbe

Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes

(2010) Scott B Halstead et al.   LANCET INFECTIOUS DISEASES

The RTS,S malaria vaccine

(2010) Sofia Casares et al.   VACCINE

The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response

(2009) R. S. Akondy et al.   JOURNAL OF IMMUNOLOGY

Zika Virus Outbreak on Yap Island, Federated States of Micronesia

(2009) Mark R. Duffy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

(2008) Denis Gaucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell-mediated immunity induced by chimeric tetravalent dengue vaccine in naive or flavivirus-primed subjects

(2008) Bruno Guy et al.   VACCINE