Article
Immunology
Qier Chen, Rong Li, Bolin Wu, Xu Zhang, Hui Zhang, Ran Chen
Summary: Dengue fever, caused by the dengue virus, is a global health threat. Developing a safe and effective vaccine is challenging due to antibody-dependent enhancement (ADE). Researchers have successfully developed a tetravalent nanoparticle vaccine that induces potent immune responses and protects against DENV-2 and DENV-3 challenges in mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Arthur da Costa Rasinhas, Fernanda Cunha Jacome, Gabriela Cardoso Caldas, Ana Luisa Teixeira de Almeida, Marcos Alexandre Nunes da Silva, Daniel Dias Coutinho de Souza, Amanda Carlos Paulino, Derick Mendes Bandeira, Raphael Leonardo, Priscila Conrado Guerra Nunes, Ronaldo Mohana-Borges, Ortrud Monika Barth, Flavia Barreto dos Santos, Debora Ferreira Barreto Vieira
Summary: DENV-4 was absent from the Brazilian epidemiological scenario for almost 25 years after its brief introduction in 1981, but emerged in 2010 causing epidemics in most states. Despite being considered a mild serotype, DENV-4 is associated with severe cases and deaths, making it worthy of investigation. The lack of suitable experimental animal models remains a limiting factor for pathogenesis studies.
Article
Immunology
S. Gowri Sankar, T. Mowna Sundan, A. Alwin Prem Anand
Summary: The study aimed to identify the molecular characteristics of DENV during the 2017 outbreak in Tamil Nadu, India, and investigate the role of inflammatory cytokines in different serotypes and dengue severity. Different cytokine expression profiles were observed in various serotypes, with DENV-4 playing a significant role in disease severity as the predominant serotype.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
F. Fahmideh, N. Marchesi, L. I. M. Campagnoli, L. Landini, C. Caramella, A. Barbieri, S. Govoni, A. Pascale
Summary: Diabetic retinopathy is one of the most common complications of diabetes, and current pharmacological approaches are limited. This study found that a molecular cascade triggered by hyperglycemia can be blocked to prevent the increase of VEGF in the retina, providing a new pharmacological option for preventing the development of diabetic retinopathy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Yueru Li, Basma Baccouche, Olamide Olayinka, Anara Serikbaeva, Andrius Kazlauskas
Summary: The study reveals that VEGF/anti-VEGF controls endothelial cell permeability by regulating multiple members of the Wnt pathway, and activating this pathway helps strengthen the endothelial cell barrier. FDA-approved agents such as LiCl may serve as adjuvants to anti-VEGF therapy for blinding conditions like diabetic retinopathy.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Peripheral Vascular Disease
Yusi Wu, Bingjie Pan, Zhen Zhang, Xiaohui Li, Yiping Leng, Yong Ji, Kun Sun, Alex F. Chen
Summary: The study reveals the critical role of caspase-4/11 in the pyroptosis pathway, which regulates pulmonary vascular dysfunction and accelerates the progression of pulmonary arterial hypertension (PAH). These findings provide a potential target for the diagnosis and treatment of PAH.
Article
Medicine, Research & Experimental
Fei Cai, Huanzong Jiang, Yan Li, Qin Li, Chao Yang
Summary: In this study, we found that SNHG16 expression was upregulated under high glucose conditions, promoting proliferation, migration, and angiogenesis of hRMECs. Functionally, SNHG16 was associated with NF-kappa B and PI3K/AKT pathways, and could sequester miR-146a-5p and miR-7-5p to regulate hRMEC dysfunction by acting as a ceRNA with IRAK1 and IRS1.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Victoria Mastej, Cassondra Axen, Anita Wary, Richard D. Minshall, Kishore K. Wary
Summary: This study reveals that KLF4 is crucial for maintaining the quiescence of endothelial cells and interacts with KLF2. Depletion of KLF4 leads to increased expression of KLF2 and triggers EndMT, resulting in lung inflammation, disruption of lung alveolar architecture, and pulmonary fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Hematology
Jiyuan Chen, Jinrui Miao, Dansha Zhou, Jing Liao, Ziyi Wang, Ziying Lin, Chenting Zhang, Xiaoyun Luo, Yi Li, Xiang Li, Shiyun Liu, Yue Xing, Zizhou Zhang, Manjia Zhao, Sophia Parmisano, Yuqin Chen, Jason X. -J. Yuan, Kai Yang, Dejun Sun, Jian Wang
Summary: Piezo1 plays an important role in pulmonary vascular remodeling during the development of pulmonary hypertension (PH). Upregulation of Piezo1 is associated with inhibited pulmonary vascular contraction and relaxation, and is related to different cell signaling pathways in pulmonary arterial smooth muscle cells (PASMCs) and endothelial cells (ECs).
THROMBOSIS RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Chenting Zhang, Wenju Lu, Xiaoyun Luo, Shiyun Liu, Yi Li, Qiuyu Zheng, Wenyan Liu, Xuefen Wu, Yuqin Chen, Qian Jiang, Zizhou Zhang, Guoping Gu, Jiyuan Chen, Haixia Chen, Jing Liao, Chunli Liu, Cheng Hong, Haiyang Tang, Dejun Sun, Kai Yang, Jian Wang
Summary: This study found that EndoMT may be present in PVOD patients and rat models, and targeted inhibition of Smad3 may be a potential therapeutic strategy to prevent the development of PVOD.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Jia-Feng Wang, Chang-Yi Shi, Hua-Zhong Ying
Summary: Antibiotic abuse is becoming more serious in clinics, and even short-term use of cephalosporins can cause dysbiosis in the gut, leading to the development and exacerbation of diseases. This study investigated the effects of cefaclor, cefdinir, and cefixime on intestinal microbiota and lung injury in Streptococcus pneumoniae-infected mice. The results showed that cephalosporin treatment disrupted the balance of intestinal microbiota, increased the risk of Spn infection, and resulted in more severe respiratory inflammation in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Mingwang Long, Yue Pan, Junying Chen, Fan Jia, Han Wang, Daiying Li, Kai Feng, Lingmei Yan, Xiaodan Wang, Xuelei Ning, Lijuan Qiu, Juan Zhang, Qiangming Sun
Summary: This study utilized RNA-Seq to investigate the differentially expressed RNAs in THP-1 cells infected with DENV-3 and ADE, revealing key pathways related to immune responses, viral infectious diseases, and cytokine interactions. Notably, the study identified up-regulation of HBB in DENV-3 vs ADE comparison, indicating potential involvement of Fc gamma Receptor-mediated phagocytosis. Furthermore, the study predicted the encoding ability of DE circRNAs, shedding light on the potential role of interferon-stimulated genes in DENV-host interactions.
Article
Biochemistry & Molecular Biology
Yuji Sasaki, Yoshiki Higashijima, Jun-Ichi Suehiro, Takehito Sugasawa, Eri Oguri-Nakamura, Shigetomo Fukuhara, Nao Nagai, Yosuke Hirakawa, Youichiro Wada, Masaomi Nangaku, Yasuharu Kanki
Summary: "Research has shown that KDM2B plays a crucial regulatory role in VEGF signaling. Knockdown of KDM2B enhances VEGF-induced angiogenesis in endothelial cells, while ectopic expression of KDM2B inhibits angiogenesis. KDM2B selectively controls the transcription levels of genes associated with VEGF-induced angiogenesis, thus affecting endothelial cell function."
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Paihe Deng, Huimin Hu
Summary: Hypoxia/reoxygenation induces endothelial cell pyroptosis through the HSP90/EZH2/miR-22/NLRP3 signaling axis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Physiology
Xin Yun, Nicolas M. Philip, Haiyang Jiang, Zion Smith, John C. Huetsch, Mahendra Damarla, Karthik Suresh, Larissa A. Shimoda
Summary: The study found that in a severe PAH model, AQP1 levels were significantly increased in pulmonary arterial smooth muscle cells and pulmonary microvascular endothelial cells, leading to abnormal cell migration and proliferation. Silencing of AQP1 normalized the enhanced migration and proliferation observed in the pathological model, highlighting the key role of enhanced AQP1 expression in mediating abnormal migration and proliferation in pulmonary vascular cells.
FRONTIERS IN PHYSIOLOGY
(2021)