Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Amelioration of Systemic Fibrosis in Mice by Angiotensin II Receptor Blockade

(2013) Wioleta Marut et al.   ARTHRITIS AND RHEUMATISM

Endothelial Injury in a Transforming Growth Factor β-Dependent Mouse Model of Scleroderma Induces Pulmonary Arterial Hypertension

(2013) Emma C. Derrett-Smith et al.   ARTHRITIS AND RHEUMATISM

Meprinβ, a novel mediator of vascular remodelling underlying pulmonary hypertension

(2013) Valentina Biasin et al.   JOURNAL OF PATHOLOGY

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

(2013) Elizabeth E. Gerber et al.   NATURE

Animal Models of Scleroderma: Current State and Recent Development

(2013) Yoshihide Asano et al.   Current Rheumatology Reports

Involvement of PDGF in Fibrosis and Scleroderma: Recent Insights from Animal Models and Potential Therapeutic Opportunities

(2013) Tomoaki Iwayama et al.   Current Rheumatology Reports

Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis

(2012) Britta Maurer et al.   ANNALS OF THE RHEUMATIC DISEASES

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

(2012) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis

(2012) Lukasz Stawski et al.   ARTHRITIS RESEARCH & THERAPY

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Immunization with DNA topoisomerase I and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling

(2011) Ayumi Yoshizaki et al.   ARTHRITIS AND RHEUMATISM

Mouse models of graft-versus-host disease: advances and limitations

(2011) M. A. Schroeder et al.   Disease Models & Mechanisms

Imatinib mesylate for the treatment of pulmonary arterial hypertension

(2011) Henrik ten Freyhaus et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Angiotensin signalling in pulmonary fibrosis

(2011) Bruce D. Uhal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Endothelial Fli1 Deficiency Impairs Vascular Homeostasis

(2010) Yoshihide Asano et al.   AMERICAN JOURNAL OF PATHOLOGY

Mutations in Fibrillin-1 Cause Congenital Scleroderma: Stiff Skin Syndrome

(2010) B. L. Loeys et al.   Science Translational Medicine

Transcription Factor Fos-Related Antigen-2 Induces Progressive Peripheral Vasculopathy in Mice Closely Resembling Human Systemic Sclerosis

(2009) Britta Maurer et al.   CIRCULATION

Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis

(2009) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Selective Oxidation of DNA Topoisomerase 1 Induces Systemic Sclerosis in the Mouse

(2009) A. Servettaz et al.   JOURNAL OF IMMUNOLOGY

Induction of Autoimmunity in a Bleomycin-Induced Murine Model of Experimental Systemic Sclerosis: An Important Role for CD4+ T Cells

(2009) Hideaki Ishikawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transforming growth factor β as a therapeutic target in systemic sclerosis

(2009) John Varga et al.   Nature Reviews Rheumatology

CD19 Regulates Skin and Lung Fibrosis via Toll-Like Receptor Signaling in a Model of Bleomycin-Induced Scleroderma

(2008) Ayumi Yoshizaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcription Factor Fli1 Regulates Collagen Fibrillogenesis in Mouse Skin

(2008) Y. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

(2008) R. Eferl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of PDGF in fibrotic diseases and systemic sclerosis

(2008) M. Trojanowska   RHEUMATOLOGY