Article
Biochemistry & Molecular Biology
Viktorija Aleksiuk, Justinas Baleisis, Gailute Kirdaite, Ilona Uzieliene, Jaroslav Denkovskij, Paulius Bernotas, Tatjana Ivaskiene, Ali Mobasheri, Eiva Bernotiene
Summary: This preclinical study aimed to determine the effect of nifedipine on healthy and OA cartilage. The study found that nifedipine exerted different effects on cartilage integrity depending on the route of administration.
Article
Endocrinology & Metabolism
Chao-Ming Chang, Yong-Chen Chen, Wen-Tung Wu, Tsung-Kun Lin, Yu-Ching Chou, Ming-Hsun Lin, Chien-An Sun
Summary: This retrospective cohort study found that patients receiving nifedipine treatment may have a potential protective effect on osteoporosis compared with other calcium channel blockers (CCBs).
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Mehmet Cinar, Sumeyra Can, Ozlem Baris, Cigdem Elif Demirci
Summary: This study determines and compares the structural and spectroscopic properties of Diltiazem and Verapamil using experimental techniques and quantum chemical calculations. The experimental and computational results are in good agreement, and both molecules show positive electron affinity and electronegativity values.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Pharmacology & Pharmacy
Liqiong Ding, Ping Jiang, Xinfeng Xu, Wanzhen Lu, Chan Yang, Lin Li, Pingzheng Zhou, Shuwen Liu
Summary: The study identified T-type calcium channel blockers as potential inhibitors of HSV-2 infection, while L-type calcium channel blockers showed no significant effect. Additionally, benidipine exerted antiviral effects by suppressing viral gene expression in the late stage of infection.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Xinyue Zhang, Xiaohua Pu, Caixia Pi, Jing Xie
Summary: FGF7, also known as KGF, plays a crucial role in tissue development, wound repair, tumorigenesis, and immune reconstruction. It directs cellular synaptic extension and facilitates functional gap junction communication in the skeletal system. Additionally, it promotes osteogenic differentiation and regulates key molecules in cartilage. However, the molecular mechanism of FGF7 in chondrocyte behaviors and cartilage diseases remains unknown.
Article
Engineering, Biomedical
Shibo Xu, Linna Chang, Xingjun Zhao, Yanan Hu, Yiyi Lin, Zhenhua Chen, Xiuli Ren, Xifan Mei
Summary: In this study, a multifunctional heterostructure nanoplatform with near-infrared sensitivity was developed for the treatment of osteoarthritis. The results showed that this nanoplatform could reduce cartilage damage and promote cartilage regeneration, providing a promising strategy for osteoarthritis treatment.
ACTA BIOMATERIALIA
(2022)
Review
Endocrinology & Metabolism
Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: CTGF is a multifunctional protein that plays different roles in different cells and conditions. CTGF antibodies have the potential to be a new drug for osteoarthritis. Abnormal CTGF expression is associated with inflammation and cartilage degeneration, making CTGF a potential therapeutic target for osteoarthritis treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Murad Aladal, Wei You, Rongxiang Huang, Jianghong Huang, Zhiqin Deng, Li Duan, Daping Wang, Wencui Li, Wei Sun
Summary: This article explores the potential of fibronectin 1 (FN1) in cartilage tissue engineering, highlighting its role in promoting chondrocyte differentiation and inhibiting apoptosis. It suggests that further research on FN1 could provide new insights and advanced applications in treating osteoarthritis and cartilage degeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Kai Sun, Jiachao Guo, Xudong Yao, Zhou Guo, Fengjing Guo
Summary: Growth differentiation factor 5 (GDF-5) plays a critical role in cartilage development and maintenance, and its dysregulation is linked to the pathogenesis of osteoarthritis (OA). Studies have shown the protective effects of GDF-5 against cartilage degeneration, making it a potential therapeutic candidate for OA treatment, despite current limitations in its clinical application.
CELL PROLIFERATION
(2021)
Review
Chemistry, Medicinal
Jhi Biau Foo, Qi Hao Looi, Chee Wun How, Sau Har Lee, Maimonah Eissa Al-Masawa, Pei Pei Chong, Jia Xian Law
Summary: Exosomes are small extracellular vesicles secreted by cells for intercellular communication, with miRNAs being a promising therapeutic factor for cartilage regeneration. They can promote chondrocyte proliferation and matrix secretion, reduce scar tissue formation, and decrease inflammation, but the optimization of exosome therapy for cartilage injuries is still lacking.
Article
Biochemistry & Molecular Biology
Denis P. Laryushkin, Sergei A. Maiorov, Valery P. Zinchenko, Sergei G. Gaidin, Artem M. Kosenkov
Summary: The study demonstrates that blockade of L-type VGCC can reduce the half-width and amplitude of bicuculline-induced [Ca2+](i) oscillations, decrease the number of PDSs in a cluster, and shorten the cluster duration, while insignificantly affecting the pattern of individual PDSs and the frequency of cluster occurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ewa Bednarczyk
Summary: This paper discusses the methods of cell cultures for investigating the mechanical causes, therapeutic solutions, and preventive methods of osteoarthritis. It focuses on the cultivation of cartilage cells to recreate the mechanical loads that contribute to the development of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Ilona Uzieliene, Ursule Kalvaityte, Eiva Bernotiene, Ali Mobasheri
Summary: Gene therapy has been explored as a potential treatment for osteoarthritis, with a focus on non-viral gene delivery technologies. While viral gene delivery has been more popular due to higher efficiency, efforts to enhance transfection efficiency of non-viral methods have shown promise for OA research and clinical applications. More research is needed to optimize transfection efficiency and duration of gene expression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhengyu Piao, Hyun Jung Lee, Byeongmoon Jeong
Summary: This study successfully induced osteoarthritis in a mouse model using a thermogel-based sustained drug release system. The results suggest that thermogels can be a precise tool for developing animal disease models by controlling drug release.
Review
Pharmacology & Pharmacy
Yanhong Song, Ziyi Wu, Ping Zhao
Summary: This article discusses the potential of using metformin in the treatment of osteoarthritis, highlighting its benefits in inhibiting inflammation, modulating autophagy, antagonizing oxidative stress, and reducing pain levels for patients. Metformin, with its anti-inflammatory and anti-aging properties, has the potential to be an effective drug for treating osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Orthopedics
Ari Vaarala, Victor Casula, Arttu Peuna, Egor Panfilov, Ali Mobasheri, Marianne Haapea, Eveliina Lammentausta, Miika T. Nieminen
Summary: In this study, a 3D texture analysis method based on gray level co-occurrence matrix was developed for knee cartilage analysis in osteoarthritis studies. The method was able to detect longitudinal changes in cartilage and distinguish different subpopulations based on their progression into radiographically confirmed osteoarthritis. The results showed significant changes in textural features of femoral and tibial cartilages across all groups and tissue layers.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Rheumatology
Vera Francisco, Jesus Pino, Miguel Angel Gonzalez-Gay, Francisca Lago, Jaro Karppinen, Osmo Tervonen, Ali Mobasheri, Oreste Gualillo
Summary: Studies have found that immunometabolic alterations in patients with obesity and type 2 diabetes mellitus are closely related to intervertebral disc degeneration, involving the abnormal production of proteins such as adipokines and exacerbation of inflammatory responses.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Cell & Tissue Engineering
Ignacio Dallo, Riccardo D'Ambrosi, Dawid Szwedowski, Ali Mobasheri, Alberto Gobbi
Summary: Bone marrow lesions (BMLs) are common findings in different knee pathologies, but the etiology and treatment protocol for symptomatic BMLs remain unclear. This study evaluates the clinical outcomes and safety of Osteo Core Plasty technique in treating symptomatic BMLs in the knee, and it shows promising results in reducing pain and improving overall scores.
STEM CELLS AND DEVELOPMENT
(2022)
Review
Orthopedics
Ursule Kalvaityte, Csaba Matta, Eiva Bernotiene, Peter Natesan Pushparaj, Ata M. Kiapour, Ali Mobasheri
Summary: This article reviews the biological roles of clusterin in cartilage, chondrocytes, and other synovial joint tissues, and discusses its potential as a biomarker in synovial and systemic fluids of patients with rheumatoid arthritis (RA) or osteoarthritis (OA). Clusterin has cytoprotective functions and may serve as a biomarker of early repair responses in OA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Chemistry, Analytical
Almira Ramanaviciene, Anton Popov, Ema Baliunaite, Benediktas Brasiunas, Asta Kausaite-Minkstimiene, Ugur Tamer, Gailute Kirdaite, Eiva Bernotiene, Ali Mobasheri
Summary: This study presents the development of a specific magnetic immunoassay method for the determination of hGH concentration in serum. The method has a low limit of detection, clinically relevant linear range, and negligible non-specific binding. Important technical solutions for the development of this sandwich-type colorimetric magneto-immunoassay are discussed.
Article
Rheumatology
Federico Angelini, Pawel Widera, Ali Mobasheri, Joseph Blair, Andre Struglics, Melanie Uebelhoer, Yves Henrotin, Anne Ca Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Christoph Ladel, Jonathan Larkin, Anne C. Bay-Jensen, Jaume Bacardit
Summary: The study found three dominant endotypes associated with three phenotypes: low tissue turnover, structural damage, and systemic inflammation. Each endotype presented different disease characteristics, indicating the potential for personalized treatment strategies in the future.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Materials Science, Multidisciplinary
Vilmos Vekony, Csaba Matta, Petra Pal, Istvan A. Szabo
Summary: Magnetic nanoparticles have promising biomedical applications like hyperthermia and cell collection. This study focused on commercially available multicomponent material NanoShuttle(TM)-PL to understand its magnetic properties. Measurements and investigations were conducted to characterize the size distribution and clustering of the magnetic nanoparticles in the composite material.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Dawid Szwedowski, Ali Mobasheri, Andrzej Moniuszko, Jan Zabrzynski, Slawomir Jeka
Summary: In patients with knee osteoarthritis, it was found that those receiving PRP treatment showed significant functional improvement within 6 months, which was superior to treatment with HA or CS; in terms of pain reduction, the CS group performed the best, but the effect decreased gradually in subsequent visits.
Review
Cell Biology
Csaba Matta, Roland Takacs, Laszlo Ducza, Rana Abdelsattar Ebeid, Heonsik Choi, Ali Mobasheri
Summary: Osteoarthritis (OA) is a chronic, progressive, and debilitating musculoskeletal condition with chronic pain as one of its main symptoms. The true source of OA pain is still unclear, despite ongoing research into its pathomechanisms. Ion channels and transporters play a key role in nociceptive pain, and this review article provides an update on their distribution and function in synovial joint tissues. It also proposes directions for the development of future analgesic therapies for OA pain.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Roland Takacs, Patrik Kovacs, Rana Abdelsattar Ebeid, Janos Almassy, Janos Fodor, Laszlo Ducza, Richard Barrett-Jolley, Rebecca Lewis, Csaba Matta
Summary: Musculoskeletal disorders are a major cause of disability globally, and their prevalence is expected to increase in the future. Stem cell therapy shows promise as a potential treatment for these disorders, but more research is needed to fully understand the biological mechanisms involved, especially in the case of osteoarthritis, which currently lacks curative treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Daiva Bironaite, Rokas Miksiunas, Edvardas Bagdonas, Raminta Vaiciuleviciute, Ali Mobasheri, Eiva Bernotiene
Summary: This study investigated the role of intracellular calcium (iCa(2+)) and its regulation through voltage-operated calcium channels (VOCC) in the chondrogenic differentiation of mesenchymal stem/stromal cells. Results showed that chondrocytes had the highest level of iCa(2+), while MenSCs had the largest iCa(2+) store capacity and proliferation ability. The expression of the CaV1.2 gene was highest in MenSCs during chondrogenic differentiation. Nifedipine, a CaV1.2 antagonist, could suppress iCa(2+) and proliferation in all cells and affect iCa(2+) stores, especially in BMMSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Roland Takacs, Judit Vago, Szilard Poliska, Peter Natesan Pushparaj, Laszlo Ducza, Patrik Kovacs, Eun-Jung Jin, Richard Barrett-Jolley, Roza Zakany, Csaba Matta
Summary: Chondrogenesis is a complex process involving the differentiation of cartilage progenitor cells. In this study, the researchers used RNA sequencing to investigate the gene expression patterns during cartilage formation in micromass cultures of embryonic limb bud-derived progenitors. They identified differentially expressed genes and confirmed their involvement in chondrogenic differentiation. Transient gene silencing experiments revealed the role of ATOH8 and EBF1 in regulating key osteochondrogenic marker genes during chondrogenesis. These findings provide a comprehensive understanding of the molecular mechanism of chondrogenesis and offer new insights for cartilage tissue engineering.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Immunology
Patrik Kovacs, Peter Natesan Pushparaj, Roland Takacs, Ali Mobasheri, Csaba Matta
Summary: This study mapped and analyzed the network of clusterin in osteoarthritis (OA) using STRING database and Cytoscape. Results showed that the clusterin network predominantly involved intracellular chaperones, aggregate-forming proteins, apoptosis regulators, and complement proteins. Additional interacting partners, including serum proteins, apolipoproteins, and heat shock proteins, were identified. These findings contribute to the identification of potential biomarker panels for prognosis and diagnosis of OA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Mehdi Ommati, Ali Mobasheri, Hossein Niknahad, Mohammad Rezaei, Sepideh Alidaee, Abdollah Arjmand, Sahra Mazloomi, Narges Abdoli, Issa Sadeghian, Samira Sabouri, Mohsen Saeed, Khadijeh Mousavi, Asma Najibi, Reza Heidari
Summary: Ammonium ion (NH4+) is suspected to be the main molecule responsible for neurological complications in hepatic encephalopathy. This study investigated the effects of the NMDA receptor antagonist ketamine on hyperammonemic mice and found that it significantly improved locomotor activity, biomarkers of oxidative stress, and decreased proinflammatory cytokines. These findings suggest that ketamine may have neuroprotective mechanisms against NH4+-induced neurotoxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)