Computational Analysis of the Binding Specificities of PH Domains

Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling

(2015) Hongzhao Li et al.   CELLULAR SIGNALLING

Characterization of All Possible Single-Nucleotide Change Caused Amino Acid Substitutions in the Kinase Domain of Bruton Tyrosine Kinase

(2015) Jouni Väliaho et al.   HUMAN MUTATION

Small chemicals with inhibitory effects on PtdIns(3,4,5)P3 binding of Btk PH domain

(2014) Youngdae Yoon   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bruton's Tyrosine Kinase: From X-Linked Agammaglobulinemia Toward Targeted Therapy for B-Cell Malignancies

(2014) Sabine Ponader et al.   JOURNAL OF CLINICAL ONCOLOGY

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Crystal Structure of the Pleckstrin Homology Domain from the Ceramide Transfer Protein: Implications for Conformational Change upon Ligand Binding

(2013) Jennifer Prashek et al.   PLoS One

Molecular Dynamic Simulation to Explore the Molecular Basis of Btk-PH Domain Interaction with Ins(1,3,4,5)P4

(2013) Dan Lu et al.   TheScientificWorldJOURNAL

Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms

(2012) Klaus Scheffzek et al.   FEBS LETTERS

Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec

(2012) Scott E. Boyken et al.   PROTEIN SCIENCE

Finding a Needle in a Haystack: The Role of Electrostatics in Target Lipid Recognition by PH Domains

(2012) Craig N. Lumb et al.   PLoS Computational Biology

The Aarskog-Scott Syndrome Protein Fgd1 Regulates Podosome Formation and Extracellular Matrix Remodeling in Transforming Growth Factor  -Stimulated Aortic Endothelial Cells

(2011) T. Daubon et al.   MOLECULAR AND CELLULAR BIOLOGY

HMMER web server: interactive sequence similarity searching

(2011) R. D. Finn et al.   NUCLEIC ACIDS RESEARCH

Understanding the relative affinity and specificity of the pleckstrin homology domain of protein kinase B for inositol phosphates

(2011) Sarah A. J. Rosen et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Biophysical and Computational Studies of Membrane Penetration by the GRP1 Pleckstrin Homology Domain

(2011) Craig N. Lumb et al.   STRUCTURE

Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

(2009) Abdalla J. Mohamed et al.   IMMUNOLOGICAL REVIEWS

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain

(2009) Qingping Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

A possible effector role for the pleckstrin homology (PH) domain of dynamin

(2009) K. A. Bethoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition

(2009) Véronique Calleja et al.   PLOS BIOLOGY

Crystal structure of the Bruton’s tyrosine kinase PH domain with phosphatidylinositol

(2008) Kazutaka Murayama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comprehensive Identification of PIP3-Regulated PH Domains from C. elegans to H. sapiens by Model Prediction and Live Imaging

(2008) Wei Sun Park et al.   MOLECULAR CELL