Article
Multidisciplinary Sciences
Malinee Thanee, Hasaya Dokduang, Yingpinyapat Kittirat, Jutarop Phetcharaburanin, Poramate Klanrit, Attapol Titapun, Nisana Namwat, Narong Khuntikeo, Arporn Wangwiwatsin, Hideyuki Saya, Watcharin Loilome
Summary: This study investigates the role of CD44 in the progression of Cholangiocarcinoma (CCA) by examining its impact on the Akt signaling pathway and metabolic profiling. The silencing of CD44 leads to decreased Akt and mTOR phosphorylation, affecting cell proliferation, migration, and invasion. Furthermore, CD44 depletion alters epithelial-mesenchymal transition, metabolic pathways, and redox status, impacting cancer cell functions.
Review
Cell Biology
Wei Liu, Chengpeng Yu, Jianfeng Li, Jiwei Fang
Summary: This paper provides a systematic summary of the roles of EphB2 in cancer and proposes future research prospects focusing on the effects of EphB2 on tumor immunity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Claire Y. Li, Stav Brown, Babak J. Mehrara, Raghu P. Kataru
Summary: The lymphatic system plays a crucial role in tumor growth and immune response. Understanding the complex interactions between lymphatic vessels, tumor cells, and the tumor microenvironment can lead to the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Qi Shang, Shiyao Zhou, Zijia Zhou, Yue Jiang, Yuxia Luan
Summary: Targeting breast cancer stem cells (BCSCs) therapy is a promising strategy to eliminate tumors by remolding the disequilibrium state and blocking the EMT process, demonstrating a potential photodynamic platform against tumor progression and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Yang Xiao, Kirill Batmanov, Wenxiang Hu, Kun Zhu, Alexander Y. Tom, Dongyin Guan, Chunjie Jiang, Lan Cheng, Sam J. McCright, Eric C. Yang, Matthew R. Lanza, Yifan Liu, David A. Hill, Mitchell A. Lazar
Summary: Current therapeutic strategies for NASH have been ineffective in alleviating liver fibrosis. This study used single-nucleus transcriptomics and epigenomics to characterize liver cell types during NASH development in mice and humans. The progression of hepatocyte trajectory with NASH was conserved between the two species. Hepatocytes exhibited metabolic adaptation at the NAFL stage, while at the NASH stage, a subset of hepatocytes showed enrichment in cell adhesion and migration signatures, mainly through the receptor tyrosine kinase EphB2. Knockdown of Ephb2 in hepatocytes ameliorated inflammation and fibrosis in a mouse model of NASH, suggesting EphB2 as a potential therapeutic target.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chong-Qing Gao, Zhen-Zhen Chu, Di Zhang, Yang Xiao, Xing-Yan Zhou, Jun-Ru Wu, Hui Yuan, Yu-Chuan Jiang, Dong Chen, Ji-Chun Zhang, Nan Yao, Kai-Yun Chen, Jian Hong
Summary: In this study, the researchers found that TBK1 was upregulated in CCA and its expression was correlated with tumor size, lymph node metastasis, and TNM stage. Functional studies revealed that TBK1 promoted CCA growth and metastasis by interacting with beta-catenin and activating EMT-related transcriptional reprogramming. Furthermore, LDLR was also upregulated in CCA and a cholesterol-conjugated DNA/RNA heteroduplex oligonucleotide targeting TBK1 effectively inhibited intrahepatic metastasis of CCA. This study suggests that TBK1 could be a potential prognostic biomarker and therapeutic target for CCA patients.
Article
Cell Biology
Xiaopeng Yu, Huanjun Tong, Jialu Chen, Chenwei Tang, Shuqing Wang, Yu Si, Shouhua Wang, Zhaohui Tang
Summary: This study discovered a lipid metabolism-related circRNA, circMBOAT2, that is upregulated in intrahepatic cholangiocarcinoma (ICC) and positively correlated with malignant features of ICC. CircMBOAT2 binds to PTBP1, protecting it from degradation and impairing its function in transferring FASN mRNA. This promotes the growth and metastasis of ICC cells and alters lipid metabolic profile and redox homeostasis. CircMBOAT2 may serve as a therapeutic target for ICC with active lipid metabolism.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Qian Li, Lei Fu, Lili Han, Shuai Li, Yanling Zhang, Jufeng Wang
Summary: The expression of GAS5 is significantly increased in cholangiocarcinoma (CCA) tissues and cells, with high GAS5 expression associated with lymph node metastasis and advanced clinical stage. GAS5 acts as an endogenous sponge to downregulate hsa-miR-1297, promoting CCA cell proliferation and invasion.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Jia Li, Zhiqiang Hu, Haoyang Xin, Chubin Luo, Jian Zhou, Jia Fan, Shaolai Zhou
Summary: The interaction between TANs and TAMs enhances the proliferation and invasion abilities of ICC cells, promoting ICC progression. They can produce Oncostatin M and interleukin-11 in co-culture, activating STAT3 signaling in ICC cells, and silencing STAT3 can disrupt the pro-tumor effect of TANs and TAMs on ICC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Limin Pan, Haibao Peng, Bowon Lee, Jiaxu Zhao, Xiulian Shen, Ximei Yan, Yipeng Hua, Jeonghyun Kim, Dokyoon Kim, Mouhong Lin, Shengjian Zhang, Xiaohui Li, Xueying Yi, Feibai Yao, Zhiyong Qin, Jiulin Du, Yudan Chi, Jwa-Min Nam, Taeghwan Hyeon, Jianan Liu
Summary: This study reports an effective, selective, and safe lysosomal alkalizer that can inhibit tumor growth and metastasis by altering the pH and function of lysosomes. The alkalizer consists of an iron oxide core and cerium oxide satellites that generate hydroxyl radicals and convert them into hydroxide ions. Alkalized lysosomes display impaired enzyme activity and autophagy, leading to cancer cell apoptosis. The alkalizer effectively inhibits tumor growth and metastasis in mice.
ADVANCED MATERIALS
(2023)
Review
Oncology
Jiuyang Liu, Xiafei Geng, Jinxuan Hou, Gaosong Wu
Summary: This article examines the critical roles of M1 and M2 macrophages in tumor progression, with M1 possessing anti-tumor properties and M2 promoting tumor growth and metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Sayra Dilmac, Nilay Kuscu, Ayse Caner, Sendegul Yildirim, Burcak Yoldas, Ammad Ahmad Farooqi, Gamze Tanriover
Summary: This study investigated the roles of SIRT and FoxO proteins in breast cancer metastasis and found that SIRT1 co-operates with FoxO proteins and plays a critical role in metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jiafeng Chen, Zheng Gao, Xiaogang Li, Yinghong Shi, Zheng Tang, Weiren Liu, Xin Zhang, Ao Huang, Xuanming Luo, Qiang Gao, Guangyu Ding, Kang Song, Jian Zhou, Jia Fan, Xiutao Fu, Zhenbin Ding
Summary: The study indicates that abundant expression of p62 is associated with the malignant progression of ICC and could serve as a potential therapeutic target in antimetastatic strategies.
Review
Oncology
Yuhe Huang, Weiqi Hong, Xiawei Wei
Summary: This review describes the molecular mechanisms, signaling pathways, and stages of tumorigenesis involved in the EMT process and discusses the role of EMT in tumor metastasis. It provides new insights and strategies for tumor therapy targeting EMT.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Chakkaphan Khenjanta, Raynoo Thanan, Apinya Jusakul, Anchalee Techasen, Wassana Jamnongkan, Nisana Namwat, Watcharin Loilome, Chawalit Pairojkul, Puangrat Yongvanit
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
(2014)
Article
Oncology
Supak Yothaisong, Malinee Thanee, Nisana Namwat, Puangrat Yongvanit, Thidarut Boonmars, Anucha Puapairoj, Watcharin Loilome
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
(2014)
Article
Oncology
Narong Khuntikeo, Nittaya Chamadol, Puangrat Yongvanit, Watcharin Loilome, Nisana Namwat, Paiboon Sithithaworn, Ross H. Andrews, Trevor N. Petney, Supannee Promthet, Kavin Thinkhamrop, Chaiwat Tawarungruang, Bandit Thinkhamrop
Article
Oncology
Wareeporn Wattanawongdon, Chariya Hahnvajanawong, Nisana Namwat, Sirimas Kanchanawat, Thidarut Boonmars, Patcharee Jearanaikoon, Chanwit Leelayuwat, Anchalee Techasen, Wunchana Seubwai
INTERNATIONAL JOURNAL OF ONCOLOGY
(2015)
Article
Oncology
Pakkayanee Sudsarn, Thidarut Boonmars, Wipaporn Ruangjirachuporn, Nisana Namwat, Watcharin Loilome, Pranee Sriraj, Ratchadawan Aukkanimart, Wonkchalee Nadchanan, Songsri Jiraporn
PATHOLOGY & ONCOLOGY RESEARCH
(2016)
Article
Biotechnology & Applied Microbiology
Minerva Daya, Watcharin Loilome, Anchalee Techasen, Malinee Thanee, Prakasit Sa-Ngiamwibool, Attapol Titapun, Puangrat Yongvanit, Nisana Namwat
ONCOTARGETS AND THERAPY
(2018)
Article
Gastroenterology & Hepatology
Hasaya Dokduang, Anchalee Techasen, Nisana Namwat, Narong Khuntikeo, Chawalit Pairojkul, Yoshinori Murakami, Watcharin Loilome, Puangrat Yongvanit
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2014)
Article
Gastroenterology & Hepatology
Runglawan Silakit, Watcharin Loilome, Puangrat Yongvanit, Porncheera Chusorn, Anchalee Techasen, Thidarut Boonmars, Narong Khuntikeo, Nittaya Chamadol, Chawalit Pairojkul, Nisana Namwat
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2014)
Article
Gastroenterology & Hepatology
Anchalee Techasen, Nisana Namwat, Watcharin Loilome, Kassaporn Duangkumpha, Anucha Puapairoj, Hideyuki Saya, Puangrat Yongvanit
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2014)
Article
Biotechnology & Applied Microbiology
Sasikamon Khophai, Malinee Thanee, Anchalee Techasen, Nisana Namwat, Poramate Klanrit, Attapol Titapun, Apiwat Jarearnrat, Prakasit Sa-Ngiamwibool, Watcharin Loilome
ONCOTARGETS AND THERAPY
(2018)
Article
Oncology
Suyanee Thongchot, Chiara Vidoni, Alessandra Ferraresi, Watcharin Loilome, Narong Khuntikeo, Sakkarn Sangkhamanon, Attapol Titapun, Ciro Isidoro, Nisana Namwat
Summary: The study validates the hypothesis that CAF infiltration and IL-6 release predict poor prognosis in CCA patients, with low stromal IL-6 and active autophagy in cancer cells correlating with better outcomes and chemotherapy response. Therapeutic strategies targeting these factors may improve survival in CCA patients.
Article
Biochemistry & Molecular Biology
Bundit Promraksa, Praewpan Katrun, Jutarop Phetcharaburanin, Yingpinyapat Kittirat, Nisana Namwat, Anchalee Techasen, Jia V. Li, Watcharin Loilome
Summary: The study demonstrated that CA can induce apoptosis in CCA cells and may serve as a potent anticancer agent for CCA treatment. CA affects the half-inhibitory concentration of CCA cells and cellular metabolism, involving antioxidant defense mechanism, glycerophospholipid metabolism, and the tricarboxylic acid cycle.
Article
Medicine, General & Internal
Preawwalee Wintachai, Jing Quan Lim, Anchalee Techasen, Worachart Lert-Itthiporn, Sarinya Kongpetch, Watcharin Loilome, Jarin Chindaprasirt, Attapol Titapun, Nisana Namwat, Narong Khuntikeo, Apinya Jusakul
Summary: The study found that cfDNA levels were significantly higher in CCA compared to benign biliary disease and normal controls. cfDNA levels showed superior diagnostic efficacy in discriminating CCA from healthy controls and BBD.
Article
Multidisciplinary Sciences
Rujikorn Treeriya, Phuc N. Ho, Attapol Titapun, Poramate Klanrit, Manida Suksawat, Thanaporn Kulthawatsiri, Suphasarang Sirirattanakul, Watcharin Loilome, Nisana Namwat, Arporn Wangwiwatsin, Nittaya Chamadol, Narong Khuntikeo, Jutarop Phetcharaburanin
Summary: In this study, nuclear magnetic resonance (NMR) metabolomics was used to investigate the fecal metabolic phenotypes of different study groups, including normal bile duct, periductal fibrosis (PDF), and cholangiocarcinoma (CCA) patients. The results revealed distinct fecal metabolic patterns in PDF and CCA patients compared to the normal bile duct group, indicating the involvement of various metabolic pathways in PDF and CCA progression. The study also highlighted the role of gut-microbial host metabolic crosstalk in PDF and/or CCA patients.