Article
Medicine, Research & Experimental
Hui Jin, Monowar Aziz, Atsushi Murao, Molly Kobritz, Andrew J. Shih, Robert P. Adelson, Max Brenner, Ping Wang
Summary: Extracellular cold-inducible RNA-binding protein (eCIRP) is a key factor in the severity and mortality of sepsis, which induces the formation of antigen-presenting aged neutrophils (APANs) through CD4+ T cell activation, Th1 polarization, and IFN-gamma-mediated hyper-NETosis. APANs exacerbate acute lung injury (ALI) and worsen the survival of septic animals. These findings highlight the role of eCIRP and APANs in sepsis pathogenesis and potential therapeutic targets.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Kai Ma, Zhaowei Sun, Xueliang Li, Jingyun Guo, Qinlei Wang, Mujian Teng
Summary: This study investigated the mechanism of FoxM1 in immune escape of hilar cholangiocarcinoma (HCCA). The results showed that overexpression of FoxM1 enhanced the inhibitory role of Treg cells in CD8(+) T killing and promoted immune escape of HCCA cells. Moreover, FoxM1 promoted the transcription of FoxP3 by binding to the FoxP3 promoter region. Silencing of FoxP3 neutralized the promoting effect of FoxMl overexpression in Treg cell immunosuppression and HCCA cell immune escape.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Hematology
Dheerendra Gupta, Ahmed Elwakiel, Satish Ranjan, Manish Kumar Pandey, Shruthi Krishnan, Saira Ambreen, Reinhard Henschler, Rajiv Rana, Maria Keller, Uta Ceglarek, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Summary: Recent research has shown that the coagulation protease activated protein C (aPC) can directly regulate adaptive immunity. Preincubation of T cells with aPC before transplantation increases FOXP3+ regulatory T cells (Tregs) and reduces acute graft-versus host disease (aGVHD) in mice, but the mechanism behind this is unknown. This study found that cellular metabolism plays a role in aPC-induced FOXP3+ expression in T cells, specifically through a decrease in glutamine and α-ketoglutarate levels, resulting in altered epigenetic markers, promoter demethylation, and induction of FOXP3 expression. These findings suggest that aPC modulates T-cell metabolism to promote a Treg-like phenotype.
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Joris van der Veeken, Clarissa Campbell, Yuri Pritykin, Michail Schizas, Jacob Verter, Wei Hu, Zhong-Min Wang, Fanny Matheis, Daniel Mucida, Louis-Marie Charbonnier, Talal A. Chatila, Alexander Y. Rudensky
Summary: The role of Foxp3 in peripheral pTreg cells and the mechanisms supporting their differentiation remain poorly understood. This study used genetic tracing to identify microbiota-induced pTreg cells and found that many of their distinguishing features were Foxp3 independent. While Foxp3 was critical for the suppression of certain diseases, pTreg cells could suppress colonic effector T cell expansion in a Foxp3-independent manner. Thus, Foxp3 and the tolerogenic signals preceding and promoting its expression confer distinct facets of pTreg functionality.
Article
Cell Biology
Helene Dubois-Pot-Schneider, Caroline Aninat, Kathrin Kattler, Karim Fekir, Kathleen Jarnouen, Virginie Cerec, Denise Glaise, Abdulrahman Salhab, Gilles Gasparoni, Kubo Takashi, Seiichi Ishida, Joern Walter, Anne Corlu
Summary: DMSO influences liver-specific gene expression and regulates gene expression through multiple regulatory factors, as well as histone acetylation and deacetylation. Additionally, there is an interplay between cytoskeleton organization and extracellular matrix remodeling with hepatocyte maturation.
Article
Neurosciences
Tugberk Kaya, Nicola Mattugini, Lu Liu, Hao Ji, Ludovico Cantuti-Castelvetri, Jianping Wu, Martina Schifferer, Janos Groh, Rudolf Martini, Simon Besson-Girard, Seiji Kaji, Arthur Liesz, Ozgun Gokce, Mikael Simons
Summary: This study identified age-related alterations of oligodendrocyte cell state in aging murine white matter and found interferon (IFN)-responsive oligodendrocytes in proximity to CD8(+) T cells. Functional lymphocytes were shown to influence the number of IFN-responsive oligodendrocytes, with T-cell checkpoint inhibition exacerbating the aging response.
NATURE NEUROSCIENCE
(2022)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Article
Oncology
Adam N. R. Cartwright, Shengbao Suo, Soumya Badrinath, Sushil Kumar, Johannes Melms, Adrienne Luoma, Archis Bagati, Assieh Saadatpour, Benjamin Izar, Guo-Cheng Yuan, Kai W. Wucherpfennig
Summary: The study demonstrates that MDSCs do not block early steps of T-cell activation but induce DNA damage and p53 pathway activation in CD8(+) T cells through an iNOS-dependent pathway.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alice Valentin-Torres, Cora Day, Jennifer M. Taggart, Nicholas Williams, Samantha R. Stubblefield, Valerie D. Roobrouck, Jelle Beyens, Anthony E. Ting
Summary: The study demonstrates that MAPC cells increase Treg frequencies by promoting Treg proliferation and CD4(+) T cell differentiation into Tregs in vitro. The induced Tregs have a more suppressive phenotype and MAPC cells promote Treg activation by inducing transitional Tregs. This process involves factors such as TGF beta and IDO, with a critical role played by CD14(+) monocytes in Treg induction by MAPC cells.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Xueping He, Rong Hu, Peng Luo, Jie Gao, Wenjiang Yang, Jiaju Li, Youjiao Huang, Feng Han, Laijun Lai, Min Su
Summary: Administration of BTN2A2-Ig attenuates established CIA, reduces activation, proliferation, and cytokine production of T cells, and has the potential to be used in the treatment of collagen-induced arthritis models.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Daniel S. Shin, Sneha Ratnapriya, Creel Ng Cashin, Lucy F. Kuhn, Rod A. Rahimi, Robert M. Anthony, James J. Moon
Summary: Self-antigen-specific T cells are regulated through tolerance mechanisms, but tissue injury can disrupt this regulation and trigger autoimmunity. Using mouse models of lung injury, we found that acute injury leads to the expansion of CD4+ regulatory T cells (Tregs) that specifically recognize self-antigen. Conventional CD4+ T cells with the same self-antigen specificity remained unresponsive even after Treg ablation. Therefore, the self-antigen-specific CD4+ T cell repertoire plays a regulatory role in limiting tissue damage and autoimmunity during acute injury.
Editorial Material
Hematology
Jayesh Tandel, Saar I. Gill
Summary: Functional decline and exhaustion are major challenges in T-cell immunotherapies. Combining CAR T cells with immune checkpoint inhibitors may not rescue already dysfunctional T cells. However, by ablating a transcription factor known to repress T-cell memory formation, Yoshikawa et al enhance memory phenotype and cytokine polyfunctionality of tumor-specific T cells.
Review
Cell Biology
Heng Wee Tan, Yan-Ming Xu, San-Hai Qin, Guo-Feng Chen, Andy T. Y. Lau
Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, with angiogenesis playing a crucial role in the growth and metastasis of lung cancer cells. While genetic regulation of angiogenesis in lung cancer is extensively studied, relatively less is known about the epigenetic regulation. Epigenetic alterations, including DNA epimodifications, histone posttranslational modifications, and noncoding RNA expression, contribute to regulating angiogenesis in lung cancer. In the future, epigenetic-based therapy is likely to emerge as a prominent approach for treating lung cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Steven Vermeulen, Bart Van Puyvelde, Laura Bengtsson del Barrio, Ruben Almey, Bernard K. K. van der Veer, Dieter Deforce, Maarten Dhaenens, Jan de Boer
Summary: This study investigates how surface topography influences nuclear morphology, histone modifications, and gene expression. The authors find that micro-topographies result in a loss of histone acetylation and nucleoli abundance, as well as a reduction in gene expression associated with chromosome organization. They also show that micro-topographies can influence the proliferation and phenotype of mesenchymal stem cells, and this effect is reversible.
Article
Gastroenterology & Hepatology
Zheng Yun Zhang, Doopyo Hong, Seung Hoon Nam, Jong Man Kim, Yong Han Paik, Jae Won Joh, Choon Hyuck David Kwon, Jae Berm Park, Gyu-Seong Choi, Kyu Yun Jang, Cheol Keun Park, Sung Joo Kim
JOURNAL OF HEPATOLOGY
(2015)
Article
Gastroenterology & Hepatology
Sangbin Han, Justin Sangwook Ko, Sang-Man Jin, Jong Man Kim, Soo Joo Choi, Jae-Won Joh, Yang Hoon Chung, Suk-Koo Lee, Mi Sook Gwak, Gaabsoo Kim
LIVER TRANSPLANTATION
(2015)
Article
Surgery
Alfred Wei Chieh Kow, Choon Hyuck David Kwon, Sanghyun Song, Jong Man Kim, Jae-Won Joh
Article
Surgery
Chan Woo Cho, Nuri Lee, Gyu-Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2018)
Article
Otorhinolaryngology
Sang Duk Hong, Min-Seok Jang, Hyun-Jin Cho, Hyo Yeol Kim, Hun-Jong Dhong, Seung-Kyu Chung, Jae-Won Joh
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2015)
Article
Surgery
Chan Woo Cho, Gyu-Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Doo Jin Kim, Jae-Won Joh
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Jae Keun Park, Ju-Il Yang, Jong Kyun Lee, Joo Kyung Park, Kwang Hyuck Lee, Kyu Taek Lee, Jae-Won Joh, Choon Hyuck David Kwon, Jong Man Kim
Article
Gastroenterology & Hepatology
Jinsoo Rhu, Jong Man Kim, Gyu-seong Choi, Jae-Won Joh
Summary: This study analyzed the clinical impact of pretransplant administration of mycophenolate mofetil in reducing intrahepatic cholangiopathy in ABO-incompatible liver transplantation. The results showed that patients who underwent open surgery and received pretransplant mycophenolate mofetil had a lower incidence of intrahepatic cholangiopathy in ABO-incompatible liver transplantation. This suggests that pretransplant mycophenolate mofetil can reduce the risk of intrahepatic cholangiopathy.
LIVER TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Young Ju Oh, Jongman Kim, Eun-Suk Kang, Jinsoo Rhu, Gyu-Seong Choi, Jae-Won Joh
Summary: This study aimed to provide evidence of antibody responses after COVID-19 vaccination in liver transplant (LT) recipients. Among the 46 patients enrolled in the study, 87% demonstrated an antibody response after the second dose of the vaccine. The study also found that patients with lower levels of immunosuppressive drugs before and after vaccination had a significantly higher antibody response.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Surgery
Nuri Lee, Sora Cha, Jongman Kim, Yunmi Lee, Enjin Kang, Hyun Jung Kim, Seung Hui Hong, Jinsoo Rhu, Gyu-Seong Choi, Jae-Won Joh
Summary: This study aims to identify the risk factors for early 30-day graft failure after deceased donor liver transplantation (DDLT), and shows that pretransplant ventilatory support is a major predisposing factor for graft failure after DDLT.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2023)
Article
Surgery
Hyo-Sin Kim, Nam-Joon Yi, Jong Man Kim, Jae-Won Joh, Kwang-Woong Lee, Kyung-Suk Suh
Summary: This study aimed to determine the survival benefit in patients with small, solitary, recurring intrahepatic HCCs based on different treatment strategies. Results showed that the OS rates of patients in the curative treatment group were significantly better than those in the TACE treatment group at 1, 3, and 5 years.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
Article
Surgery
Minjeong Kim, Jinsoo Rhu, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh
Summary: The study identified several risk factors associated with poor survival after hepatocellular carcinoma recurrence following liver transplantation, including graft from living donor, recurrence-free interval of >= 9 months, alpha-fetoprotein of >= 100 ng/mL at the time of recurrence, recurrence in bone, and everolimus within 3 months after recurrence.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
Article
Surgery
Yu Jeong Bang, Joo Hyun Jun, Mi Sook Gwak, Justin Sangwook Ko, Jong Man Kim, Gyu Seong Choi, Jae Won Joh, Gaab Soo Kim
Summary: The study compared the impact of purely laparoscopic donor hepatectomy (PLDH) and two other types of open living donor hepatectomy (OLDH) on postoperative pain and recovery. The results showed that while PLDH did not reduce postoperative pain, it was associated with faster recovery compared to OLDH.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jisun Lee, Woo Kyoung Jeong, Jae-Hun Kim, Jong Man Kim, Tae Yeob Kim, Gyu Seong Choi, Choon Hyuck David Kwon, Jae-Won Joh, Sang-Yong Eom
Summary: The study found that preoperative muscle depletion is significantly associated with reduced survival after liver transplantation. This suggests that changes in muscle mass prior to surgery can be considered as a prognostic factor for patient outcomes following liver transplantation.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Surgery
Joo Hyun Oh, Dong Hyun Sinn, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh, Tae Wook Kang, Dongho Hyun, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Moon Seok Choi
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2020)