Article
Biochemistry & Molecular Biology
Da Hyeon Choi, Kyeong Eun Lee, Jiwon Park, Yoon Jeong Park, Jue-Yeon Lee, Yoon Shin Park
Summary: Recent research has shown that epithelial cells and fibroblasts can be converted into each other through trans-differentiation. The Oct4 transcription factor combined with LMWP can induce stem cell-like properties in fibroblasts, improving their stemness level and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Weiwei Xue, Caixia Fan, Bing Chen, Yannan Zhao, Zhifeng Xiao, Jianwu Dai
Summary: Transplantation of neural stem cells shows promise for restoring communication in spinal cord injury, but the inhibitory microenvironment often leads to glial differentiation rather than neuronal differentiation. Functional biomaterials can mitigate the adverse effects of the SCI microenvironment and promote neuronal differentiation of NSCs.
Article
Neurosciences
Francesca Sironi, Fabiola De Marchi, Letizia Mazzini, Caterina Bendotti
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons and neuromuscular impairment. Stem cell therapy shows promise in protecting motor units through various mechanisms. However, more coordinated effort and research is needed to address challenges in stem cell source selection, mechanism of action, and expected clinical outcomes. This review covers recent advances in stem cell therapies in ALS animal models and ongoing human clinical trials.
BRAIN RESEARCH BULLETIN
(2023)
Review
Cell & Tissue Engineering
Marta Roccio
Summary: Hearing loss is commonly caused by the loss or malfunction of cells in the cochlea, which cannot be reversed in mammals. Studying gene and cellular functions in different animal models helps identify disease causes and potential targets for hearing restoration. Stem cell technologies have allowed the generation of human sensory cell types in vitro, offering new tools for studying human inner ear biology, modeling disease, and validating therapeutics.
Article
Medicine, Research & Experimental
Zhiwei Li, Ye Qi, Lei Sun, Zheng Li, Shaojuan Chen, Yuqi Zhang, Yuan Ma, Jinming Han, Zide Wang, Yulin Zhang, Huimin Geng, Bin Huang, Jian Wang, Gang Li, Xingang Li, Shaohua Wu, Shilei Ni
Summary: The 3D nanofibrous sponges developed in this study show promise for the treatment of spinal cord injury by promoting neuronal regeneration and fiber regrowth. In a rat SCI model, these scaffolds not only restored neural function but also facilitated axon reinnervation and remyelination.
Article
Cell Biology
Andres Stucky, Li Gao, Shengwen Calvin Li, Lingli Tu, Jun Luo, Xi Huang, Xuelian Chen, Xiaoqing Li, Tiffany H. Park, Jin Cai, Mustafa H. Kabeer, Ashley S. Plant, Lan Sun, Xi Zhang, Jiang F. Zhong
Summary: Using single-cell sequencing, this study discovered a carcinogenic pathway in undifferentiated mesenchymal stem cells (MSCs) of differentiated resistance subclones. The expression of YAP1, OCT4, and CDH6 was upregulated in the subclones and YAP1 inhibition promoted differentiation and suppressed their expression. Clinical data confirmed the co-expression of YAP1, OCT4, and CDH6 in various solid tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Materials Science, Biomaterials
Jun Zhou, Yaqi Wu, Zhijian Tang, Kaipeng Zou, Juan Chen, Zuowei Lei, Xueyan Wan, Yanchao Liu, Huaqiu Zhang, Yu Wang, Armin Blesch, Ting Lei, Shengwen Liu
Summary: Studies have shown that alginate capillary hydrogels can fill the lesion cavity and promote axonal regeneration after grafting into the injured spinal cord. Neural stem/progenitor cells (NSPCs) can survive, proliferate, and differentiate into neurons within the capillaries in vitro. In animal experiments, a portion of the grafted cells can survive and differentiate into neurons, astrocytes, and oligodendrocytes. Furthermore, the grafted cells can promote the growth of host axons, form putative synapses with host neurons, improve electrophysiological conductivity, and partially restore locomotor function.
REGENERATIVE BIOMATERIALS
(2022)
Article
Obstetrics & Gynecology
Emily R. Smith, William M. Curtin, Kevin P. Yeagle, Nurgul Carcacki-Salli, Serdar H. Ural
Summary: This study aimed to determine the feasibility of identifying and quantifying mesenchymal stem cells (MSCs) from umbilical cord blood (UCB) after delayed cord clamping in preterm and term births. The results showed that MSCs were successfully identified in UCB samples obtained after delayed cord clamping in both preterm and term births, with no significant difference in MSC numbers between the two groups.
REPRODUCTIVE SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Min Hao, Lu Chen, Jianlong He, Xiaolei Zhao, He Xia, Xin Chen, Liyang Yu, Jichuan Qiu, Shiqing Feng, Yuanhua Sang, Hengxing Zhou, Hong Liu
Summary: In this study, 3D bioactive hydroxyapatite (HAp) nanobelt haystack-mouse NSC (mNSC) hybrid spheroids were customized to address the challenges of using neural stem cells (NSCs) in spinal cord injury (SCI). The specific nanobelt haystack framework provided hypoxia alleviation and neural differentiation promotion. The engineered bioresponsive 3D nanobelt haystack-mNSC hybrid spheroids effectively repaired SCI in vivo, demonstrating the potential of incorporating nanomaterials and cell-material interactions in stem cell therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Cell Biology
Emily A. B. Gilbert, Nishanth Lakshman, Kylie S. K. Lau, Cindi M. Morshead
Summary: Spinal cord injury affects millions of people worldwide, and there is currently no cure. Utilizing endogenous neural stem cells (NSCs) to replace lost cells and promote structural repair is a promising approach. However, there are still many unanswered questions regarding the heterogeneity of NSCs, their interaction with the environment, and factors that enhance their response.
Review
Neurosciences
Zhe-Lun Yang, Jian Rao, Fa-Bin Lin, Ze-Yan Liang, Xiong-Jie Xu, Yi-Ke Lin, Xin-Yao Chen, Chun-Hua Wang, Chun-Mei Chen
Summary: Spinal cord injury (SCI) has significant impacts on both patients' quality of life and their families. While cell therapy has made major breakthroughs in treating SCI, it also has disadvantages. In recent years, there has been growing interest in the potential therapeutic role of exosomes and exosomal ncRNAs in SCI treatment. They may be promising tools for treating spinal cord injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Immunology
Cong Zeng, Yan Chen, Juan Hua, Yi Liu, Ting-ting Cheng, Xia Ma, Xu Chen, Shi-yu Wang, Ya-jing Xu
Summary: This retrospective study analyzed the outcomes of 80 patients with hematologic malignancies who received haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) combined with unrelated cord blood (UCB). Satisfactory results were obtained with high engraftment rates and relatively low rates of transplant-related complications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ines Serrenho, Miguel Rosado, Alexandra Dinis, Carla M. Cardoso, Mario Graos, Bruno Manadas, Graca Baltazar
Summary: Neonatal hypoxic-ischemic encephalopathy is a significant cause of mortality and morbidity in the perinatal period, and therapeutic hypothermia is the standard care; however, stem cell therapy shows potential to become the next therapeutic approach, with preclinical studies reporting significant improvement in cognitive function and brain damage in HIE patients. Further research is needed to explore the combination of therapeutic hypothermia and stem cell therapy for HIE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Haofei Wang, Yuchen Yang, Jiandong Liu, Li Qian
Summary: Direct reprogramming converts cells from one lineage into another without going through a pluripotent state, and it is a promising strategy for generating functional cells for therapeutic purposes. Recent advancements include using defined factors for lineage conversion, enhancing reprogrammed cell maturation, and addressing challenges in in vivo direct reprogramming for translational applications.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Lindsay Zhou, Courtney McDonald, Tamara Yawno, Graham Jenkin, Suzanne Miller, Atul Malhotra
Summary: Cell therapies using umbilical cord blood and cord tissue have emerged as a promising approach for preventing and treating neonatal morbidities. Published clinical studies mainly focus on safety and feasibility, with limited assessment of efficacy. There are ongoing trials investigating the potential of these therapies in neonates.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Amelia E. Firor, Alexander Jares, Yupo Ma
EXPERIMENTAL BIOLOGY AND MEDICINE
(2015)
Article
Oncology
K. Pinz, H. Liu, M. Golightly, A. Jares, F. Lan, G. W. Zieve, N. Hagag, M. Schuster, A. E. Firor, X. Jiang, Y. Ma
Article
Oncology
Kevin H. Chen, Masayuki Wada, Amelia E. Firor, Kevin G. Pinz, Alexander Jares, Hua Liu, Huda Salman, Marc Golightly, Fengshuo Lan, Xun Jiang, Yupo Ma
Article
Oncology
K. H. Chen, M. Wada, K. G. Pinz, H. Liu, K-W Lin, A. Jares, A. E. Firor, X. Shuai, H. Salman, M. Golightly, F. Lan, L. Senzel, E. L. Leung, X. Jiang, Y. Ma
Article
Oncology
Kevin G. Pinz, Elizabeth Yakaboski, Alexander Jares, Hua Liu, Amelia E. Firor, Kevin H. Chen, Masayuki Wada, Huda Salman, William Tse, Nabil Hagag, Fengshuo Lan, Elaine Lai-Han Leung, Xun Jiang, Yupo Ma
Editorial Material
Cell Biology
Amelia E. Firor, Alexander Jares
Article
Cell & Tissue Engineering
Chuanfeng Wu, Brian Li, Rong Lu, Samson J. Koelle, Yanqin Yang, Alexander Jares, Alan E. Krouse, Mark Metzger, Frank Liang, Karin Lore, Colin O. Wu, Robert E. Donahue, Irvin S. Y. Chen, Irving Weissman, Cynthia E. Dunbar
Article
Biotechnology & Applied Microbiology
Chuanfeng Wu, Alexander Jares, Thomas Winkler, Jianjun Xie, Jean-Yves Metais, Cynthia E. Dunbar
HUMAN GENE THERAPY
(2013)
Article
Medicine, Research & Experimental
Chuanfeng Wu, So Gun Hong, Thomas Winkler, David M. Spencer, Alexander Jares, Brian Ichwan, Alina Nicolae, Vicky Guo, Andre Larochelle, Cynthia E. Dunbar
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2014)
Article
Biochemistry & Molecular Biology
Natasha M. Nesbitt, Lisa E. Malone, Zhaoyan Liu, Alexander Jares, Dmitri V. Gnatenko, Yupo Ma, Wei Zhu, Wadie F. Bahou
Summary: The cytoprotective functions of heme oxygenases involve the generation of carbon monoxide, ferrous iron, and bilirubin, with downstream biliverdin reductases playing a key role in cellular protection, especially in stress hematopoiesis. Blvrb is identified as a crucial driver in stress cytoprotection and redox-regulated lineage partitioning in erythroid/megakaryocyte lineage speciation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)