Article
Chemistry, Multidisciplinary
Lulu Zheng, Yan Fan, Xiang Wang, Zhijin Yang, Yule Zhang, Tingting Liu, Mengya Chen, Shifei Kang, Shiwei Guo, Zheng Shi, Yuwen Wang, Kejie Zheng, Shuqi Cai, Bo Dai, Songlin Zhuang, Yuhao Li, Dawei Zhang
Summary: Immunotherapy has significantly improved cancer treatment, but its efficacy is limited in tumors with low immune infiltration. This study introduces a novel photoimmunotherapy approach that remodels the inflammatory microenvironment and enhances the effectiveness of anti-PD-1 immunotherapy through cell pyroptosis and immune cell recruitment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cell Biology
Chenqiang Jia, Zhuqing Zhang, Jun Tang, Mei-Chun Cai, Jingyu Zang, Kaixuan Shi, Yunheng Sun, Jie Wu, Hailei Shi, Weiping Shi, Pengfei Ma, Xiaojing Zhao, Zhuang Yu, Yujie Fu, Guanglei Zhuang
Summary: EMT gene signatures are positively correlated with GSDME levels in human cancers, and EMT plays a causal role in the reversible upregulation of GSDME. Core EMT-activating transcription factors ZEB1/2 directly drive the transcriptional activation of GSDME. Elevated GSDME in mesenchymally transdifferentiated derivatives can induce pyroptotic cell death and cytokine release upon exposure to antineoplastic drugs, suggesting therapeutic potential for mesenchymal malignancies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Chen-Ying Fan, Fang-Hua Ye, Min Peng, Jia-Jia Dong, Wen-Wen Chai, Wen-Jun Deng, Hui Zhang, Liang-Chun Yang
Summary: Pyroptosis, a newly discovered mode of programmed cell death, plays an important role in cancer development. The non-histone nuclear protein HMGB1 is closely related to tumor development and chemotherapy resistance. However, the role of endogenous HMGB1 in regulating pyroptosis in neuroblastoma is still unknown.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Wen Li, Jing Sun, Xiaoxi Zhou, Yue Lu, Wenpeng Cui, Lining Miao
Summary: Pyroptosis is a lytic programmed cell death that plays a crucial role in diabetic complications. Research has identified various signaling pathways associated with pyroptosis, and explored the potential value of pyroptosis inhibitors in the treatment of diabetic nephropathy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Xiujin Shen, Haibing Wang, Chunhua Weng, Hong Jiang, Jianghua Chen
Summary: This study investigated the impact of chemotherapeutic drugs cisplatin or doxorubicin on renal tubular epithelial cells, revealing that these drugs induce the cleavage of GSDME, leading to pyroptosis. By inhibiting GSDME, cell damage and inflammation caused by the drugs can be alleviated. The findings suggest that therapies targeting GSDME may be effective in reducing chemotherapeutic drug-induced nephrotoxicity.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Chaoze Jiao, Haidan Zhang, Hongyao Li, Xu Fu, Yujie Lin, Chenglong Cao, Shixian Liu, Yijing Liu, Peiwu Li
Summary: The inflammatory response helps combat pathogens, but excessive inflammation in sepsis can cause tissue and organ damage. Pyroptosis, a form of programmed cell death executed by the GSDMs family, has been identified as a crucial component of the sepsis mechanism. While previous research has focused on one pathway, there is a lack of study on other GSDMs family members in sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ming-Zhen Cheng, Bo-Bo Yang, Ze-Tao Zhan, Si-Min Lin, Zhe-Ping Fang, Yi Gao, Wei-Jie Zhou
Summary: This study found that high expression of MACC1 and low expression of GSDME in colorectal cancer is associated with drug resistance, tumor proliferation, and recurrence. Therefore, by detecting the expression levels of MACC1 and GSDME, colorectal cancer patients can be divided into resistant and sensitive groups to determine personalized treatment strategies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang, Jianchuan Xia, Chong Zhao
Summary: This study found that GSDME-dependent pyroptosis is a critical determinant of radiosensitivity in nasopharyngeal carcinoma (NPC), and it is modulated by OTUD4. These findings have important implications for research on radioresistance and potential therapeutic targets for sensitizing NPC to radiotherapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Qianyue Chen, Jiashuo Zheng, Dingyu Wang, Qiyao Liu, Lulu Kang, Xiang Gao, Zhaoyu Lin
Summary: The study identified nitrosonisoldipine (NTS) as a selective inhibitor of inflammatory caspases, blocking both noncanonical and canonical pyroptotic pathways, with potential therapeutic value for sepsis.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Fisheries
Shouwen Chen, Peng Jin, Hao Chen, Di Wu, Shuxin Li, Yuanxing Zhang, Qin Liu, Dahai Yang
Summary: The study reveals that the inflammatory caspase in turbot can mediate both non-canonical and canonical inflammasome pathways, playing a critical role in NLRP3 inflammasome and cytosolic LPS recognition, regulating inflammatory and immune responses.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Kailin Yang, Tingting Bao, Jinsong Zeng, Shanshan Wang, Xiao Yuan, Wang Xiang, Hao Xu, Liuting Zeng, Jinwen Ge
Summary: Ischemic stroke is a leading cause of death and disability, with unclear pathogenesis but involving inflammatory cascade. Current clinical practice focuses on restoring blood supply to the affected area through thrombolytic therapy, but reperfusion further accelerates damage and causes ischemia-reperfusion injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jing Xia, Changbin Chu, Wanqing Li, Hong Chen, Wenhua Xie, Rui Cheng, Kai Hu, Xi Li
Summary: UCP1 can inhibit the proliferation and metastasis of TNBC by activating mitochondrial autophagy and pyroptosis. GSDME is activated in TNBC cells when UCP1 levels are high. Impaired activation of mitochondrial autophagy weakens UCP1's regulation effect on TNBC metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Colleen Elsa Johns, Lakshmi Galam
Summary: Scientists made a significant breakthrough in pathogen recognition through GBP1, expanding our understanding of GBP1 and providing potential therapeutic targets for inflammasome-mediated human disorders.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Immunology
Wen Chen, Jessica M. M. Gullett, Rebecca E. E. Tweedell, Thirumala-Devi Kanneganti
Summary: Regulated cell death (RCD) is important for host survival during pathogen invasion and cellular disturbances. This review focuses on the newly discovered RCD pathway called PANoptosis, which is an inflammatory cell death pathway regulated by PANoptosome complexes. The article discusses the molecular components of PANoptosomes, their assembly, activation, regulation, and their link to diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biology
Zikai Zhao, Qi Li, Usama Ashraf, Mengjie Yang, Wenjing Zhu, Jun Gu, Zheng Chen, Changqin Gu, Youhui Si, Shengbo Cao, Jing Ye, Jan E. Carette
Summary: The study reveals a novel mechanism of ZIKV-induced adverse fetal outcomes by causing placental cell pyroptosis.
Article
Spectroscopy
Xiaoli Li, Zhaoshui Yu, Jinli Xu, Yanshan Pan, Wei Bo, Bin Liu, Pengpeng Zhang, Jinfeng Bai, Qin Zhang
Summary: A new sample preparation technique using high pressure pressed pellet and coated with a polyester film is proposed for major and trace element determination in geochemical samples by wavelength dispersive X-ray fluorescence spectrometer. The accuracy of the method is evaluated using calibration curves created with reference materials and certified reference materials.
X-RAY SPECTROMETRY
(2023)
Article
Statistics & Probability
Jingfei Zhang, Will Wei Sun, Lexin Li
Summary: In this article, a new generalized matrix response regression model is proposed for the analysis of multiple-subject network data. The model characterizes the connectivity pattern of the network data and the effect of subject covariates through a low-rank intercept matrix and a sparse slope tensor, respectively. An efficient parameter estimation algorithm is developed, and an error bound for the estimator's accuracy is established. The efficacy of the method is demonstrated through simulations and brain connectivity studies.
JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS
(2023)
Article
Chemistry, Medicinal
Jingjing Zhang, Hualing Zhu, Lixia Xiong, Jun Shi, Zhiqiang Huang
Summary: By designing and synthesizing benzoylureas analogues with carbamate groups, it was found that these compounds exhibited good larvicidal activities against a broad spectrum of insects such as oriental armyworm, diamondback moth, and mosquito. One compound (3g) showed the highest insecticidal activity against oriental armyworm.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Article
Gastroenterology & Hepatology
Andrew D. Schreiner, Jingwen Zhang, William P. Moran, David G. Koch, Justin Marsden, Sherry Livingston, Patrick D. Mauldin, Mulugeta Gebregziabher
Summary: This study aims to investigate the association between FIB-4 risk strata and the incidence of severe liver disease (SLD) in primary care patients without known chronic liver disease (CLD). The results indicate that indeterminate and high-risk FIB-4 strata are associated with an increased incidence of SLD.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Chao Xu, Xiaoli Xie, Ning Kang, Huiqing Jiang
Summary: The study investigated the efficacy and safety of neoadjuvant S-1 plus oxaliplatin combined with PD-1 inhibitor and apatinib (SOXPA) in locally advanced gastric cancer (LAGC) patients. The results showed that this treatment achieved satisfactory clinical response, pathological response, survival profile, and manageable safety in LAGC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Meghan K. Thomas, Marc E. Heincelman, Jingwen Zhang, Justin Marsden, Jennifer Dulin, Patrick Robbins, Kelly Hunt, Patrick Mauldin, William P. Moran, Benjamin Kalivas
Summary: Patients admitted via interhospital transfer are more likely to experience in-hospital delirium, leading to increased mortality, length of stay, and discharge to facility. Routine screening and intervention prior to patient transfer are emphasized.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Materials Science, Ceramics
Yanling Cheng, Haoxian Huang, Xinxin Xi, Yuqiang Deng, Hainan Zhang, Chengyong Wang, Huatay Lin
Summary: Al flake addition significantly improves the properties of vinyl-polysilazane based photo-curable resin derived ceramics (P-PDCs), reducing macroscopic cracking and micrometer voids. Pyrolyzed P-PDCs with 0.6 wt% Al flake content exhibit the highest Vickers hardness and bending strength. Nano-indentation measurements show increased elastic modulus and indentation hardness with increasing Al flake content. During pyrolysis, the reacted Al flake forms hollow lamellar Al2O3 phases, enhancing both the mechanical properties and gas release.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Fisheries
Pingping Li, Haihong Chen, Jingyu Zhang, Xiaoqing Feng, Baoheng Xiao, Yiyi Hu, Zhenghong Sui
Summary: In recent years, changes in the concentrations and compositions of nutrients in the ocean have negatively affected the biomass and quality of macroalgae. A strain of Gracilariopsis lemaneiformis with a curly branch phenotype has been discovered in China, causing negative impacts on the cultivation industry. The abnormality of this strain is correlated with the concentration of nitrogen and phosphorus, and certain biological processes are down-regulated compared to the normal strain.
Article
Cell Biology
Shuang Hao, Jingchao Zhang, Yu Pei, Longhui Guo, Zhenxing Liang
Summary: This study found that epicardial adipose tissue (EAT) mediates cardiomyocyte apoptosis after acute myocardial infarction (MI) through secretion of complement factor D (CFD) and activation of PARP-1 activity. This discovery offers key targets for intervention in acute MI.
CELLULAR SIGNALLING
(2023)
Article
Chemistry, Physical
Shuxiang Wen, Xin Li, Jingjing Zhang, Jie Wang, Hao Ding, Ningshuang Zhang, Dongni Zhao, Liping Mao, Shiyou Li
Summary: This study investigates the compatibility of Na2Ti3O7@C anode material with sodium perchlorate (NaClO4)-based and sodium trifluoromethyl sulfonate (NaCF3SO3)-based electrolytes in sodium ion batteries (SIBs). The results reveal that the NaCF3SO3-based electrolyte forms a thin, compact, and uniform solid electrolyte interphase (SEI) film, which reduces the transmission energy barrier of Na+ and improves the cycling and rate performance of batteries. In contrast, the NaClO4-based electrolyte leads to the formation of a thicker SEI film containing Na(2)CO(3) and NaF, resulting in higher interface impedance and decreased battery cycle performance.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Green & Sustainable Science & Technology
Feng Liu, Qingwen Long, Guiquan Che, Zhihao Zhang, Mick Cooper, Jing Zhang, Gang Pan, Wentao Jiao
Summary: In this study, a novel method of coating polyelectrolytes on holey graphene oxide was used to modify the surface charge of the membrane, resulting in improved water flux and desalination performance.
JOURNAL OF CLEANER PRODUCTION
(2023)
Editorial Material
Surgery
Shanel Normandin, Tyler Safran, Ryan Mitchell, Peter Davison, Sebastian Winocour, Edward Reece, Mirko S. S. Gilardino, Liqin Xu, Joshua Vorstenbosch
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Green & Sustainable Science & Technology
Yingbo Zhang, Kui Shan, Xiuming Li, Hangxin Li, Shengwei Wang
Summary: Data centers have attracted worldwide attention due to their high energy consumption, and high-temperature data centers could save significant cooling energy. However, addressing technical bottlenecks and ensuring equipment reliability are essential before implementing high-temperature data centers. This paper provides a comprehensive review of these critical aspects, categorizing and analyzing the benefits, bottlenecks, and potential solutions.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Genetics & Heredity
Hsien-Yu Fan, Wan-Yu Lin, Tzu-Pin Lu, Yun-Yu Chen, Justin BoKai Hsu, Sung-Liang Yu, Ta-Chen Su, Hung-Ju Lin, Yang-Ching Chen, Kuo-Liong Chien
Summary: This study used targeted next-generation sequencing to investigate the association between genetic variants and left ventricular mass, and identified candidate genes including CASQ2, COL5A1, and FXN. These findings provide important insights into the functional mechanisms of these genes and variants.
FRONTIERS IN GENETICS
(2023)
Review
Oncology
Yuchen Zhang, Chongjie Yao, Ziyong Ju, Danli Jiao, Dan Hu, Li Qi, Shimin Liu, Xueqing Wu, Chen Zhao
Summary: Kruppel-like factors (KLFs) are DNA-binding transcriptional regulators that play essential roles in various cellular processes, including tumor development. They regulate multiple signaling pathways and mediate crosstalk among them, and their abnormal expression is closely associated with tumor cell characteristics and alterations in the tumor microenvironment. The role of each KLF in tumors varies depending on tumor type and stage of development. This review focuses on the molecular biology of KLFs, the regulation of classical signaling pathways by these factors, and their potential as molecular targets in tumor therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)