Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

A Triple Mutant in the Ω-loop of TEM-1 β-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis

(2015) Vlatko Stojanoski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum β-Lactamases

(2014) Carolyn J. Adamski et al.   BIOCHEMISTRY

Phenotypic and Enzymatic Comparative Analysis of the KPC Variants, KPC-2 and Its Recently Discovered Variant KPC-15

(2014) Dongguo Wang et al.   PLoS One

BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

(2013) Nicholas G. Brown et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

KPC-9, a Novel Carbapenemase from Clinical Specimens in Israel

(2012) Carlos Hidalgo-Grass et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic Resistance and Substrate Profiles of the Class A Carbapenemase KPC-6

(2012) Toni L. Lamoureaux et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Using Nucleic Acid Microarrays To Perform Molecular Epidemiology and Detect Novel  -Lactamases: a Snapshot of Extended-Spectrum  -Lactamases throughout the World

(2012) C. Lascols et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The Basis for Carbapenem Hydrolysis by Class A β-Lactamases: A Combined Investigation using Crystallography and Simulations

(2012) Fátima Fonseca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ExPASy: SIB bioinformatics resource portal

(2012) P. Artimo et al.   NUCLEIC ACIDS RESEARCH

Carbapenems: Past, Present, and Future

(2011) Krisztina M. Papp-Wallace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiological Expansion, Structural Studies, and Clinical Challenges of New β-Lactamases from Gram-Negative Bacteria

(2010) Karen Bush et al.   Annual Review of Microbiology

Emerging carbapenemases: a global perspective

(2010) Timothy R. Walsh   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens

(2010) Yvonne Pfeifer et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Multiple Global Suppressors of Protein Stability Defects Facilitate the Evolution of Extended-Spectrum TEM β-Lactamases

(2010) Nicholas G. Brown et al.   JOURNAL OF MOLECULAR BIOLOGY

Detection of KPC in Acinetobacter spp. in Puerto Rico

(2009) I. E. Robledo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Beta-lactam antibiotics: from antibiosis to resistance and bacteriology

(2009) KOK-FAI KONG et al.   APMIS

The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria

(2009) Patrice Nordmann et al.   LANCET INFECTIOUS DISEASES

Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

(2009) Cesar A. Arias et al.   NEW ENGLAND JOURNAL OF MEDICINE

In the light of directed evolution: Pathways of adaptive protein evolution

(2009) J. D. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic and Enzymatic Comparative Analysis of the Novel KPC Variant KPC-5 and Its Evolutionary Variants, KPC-2 and KPC-4

(2008) D. J. Wolter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic Structures at the Origin of Acquisition of the  -Lactamase blaKPC Gene

(2008) T. Naas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1

(2008) Michiyosi Nukaga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY