Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

Expanding the Binding Envelope of CYP51 Inhibitors TargetingTrypanosoma cruziwith 4-Aminopyridyl-Based Sulfonamide Derivatives

(2014) Debora F. Vieira et al.   CHEMBIOCHEM

Sequence variation in CYP51A from the Y strain ofTrypanosoma cruzialters its sensitivity to inhibition

(2014) Tatiana S. Cherkesova et al.   FEBS LETTERS

4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

(2014) Claudia M. Calvet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Determinants of disease phenotype in trypanosomatid parasites

(2014) Laura-Isobel McCall et al.   TRENDS IN PARASITOLOGY

R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi

(2014) Jun Yong Choi et al.   ACS Medicinal Chemistry Letters

Genome-Wide Stochastic Adaptive DNA Amplification at Direct and Inverted DNA Repeats in the Parasite Leishmania

(2014) Jean-Michel Ubeda et al.   PLOS BIOLOGY

The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

(2014) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Safety and Efficacy of Single Dose versus Multiple Doses of AmBisome® for Treatment of Visceral Leishmaniasis in Eastern Africa: A Randomised Trial

(2014) Eltahir A. G. Khalil et al.   PLoS Neglected Tropical Diseases

LmaPA2G4, a Homolog of Human Ebp1, Is an Essential Gene and Inhibits Cell Proliferation in L. major

(2014) Brianna Norris-Mullins et al.   PLoS Neglected Tropical Diseases

Sterol Biosynthesis Is Required for Heat Resistance but Not Extracellular Survival in Leishmania

(2014) Wei Xu et al.   PLoS Pathogens

Therapeutic Options for Visceral Leishmaniasis

(2013) Begoña Monge-Maillo et al.   DRUGS

Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas Agents

(2013) Jun Yong Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploring Leishmania donovani 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) as a potential drug target by biochemical, biophysical and inhibition studies

(2013) Neeradi Dinesh et al.   MICROBIAL PATHOGENESIS

Voriconazole suppresses the growth of Leishmania species in vitro

(2013) Manjusha M. Kulkarni et al.   PARASITOLOGY RESEARCH

Determinants for the Development of Visceral Leishmaniasis Disease

(2013) Laura-Isobel McCall et al.   PLoS Pathogens

Involvement of the Leishmania donovani virulence factor A2 in protection against heat and oxidative stress

(2012) Laura-Isobel McCall et al.   EXPERIMENTAL PARASITOLOGY

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

(2012) Shamila S. Gunatilleke et al.   PLoS Neglected Tropical Diseases

Successful Treatment of Old World Cutaneous Leishmaniasis Caused byLeishmania infantumwith Posaconazole

(2011) A. E. Paniz Mondolfi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sterol 14alpha-Demethylase (CYP51) as a Therapeutic Target for Human Trypanosomiasis and Leishmaniasis

(2011) Galina I. Lepesheva et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania

(2011) M. B. Rogers et al.   GENOME RESEARCH

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

(2011) T. Downing et al.   GENOME RESEARCH

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) fromLeishmania infantum

(2011) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CYP5122A1, a Novel Cytochrome P450 Is Essential for Survival of Leishmania donovani

(2011) Smriti Verma et al.   PLoS One

A Nonazole CYP51 Inhibitor Cures Chagas' Disease in a Mouse Model of Acute Infection

(2010) P. S. Doyle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural basis for conservation in the CYP51 family

(2010) Galina I. Lepesheva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Localization and induction of the A2 virulence factor in Leishmania: evidence that A2 is a stress response protein

(2010) Laura-Isobel McCall et al.   MOLECULAR MICROBIOLOGY

Single-Dose Liposomal Amphotericin B for Visceral Leishmaniasis in India

(2010) Shyam Sundar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential inLeishmania major

(2009) Silvane M. F. Murta et al.   MOLECULAR MICROBIOLOGY

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

(2009) Chiung-Kuang Chen et al.   PLoS Neglected Tropical Diseases