Sequence variation in CYP51A from the Y strain ofTrypanosoma cruzialters its sensitivity to inhibition
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Sequence variation in CYP51A from the Y strain ofTrypanosoma cruzialters its sensitivity to inhibition
Authors
Keywords
-
Journal
FEBS LETTERS
Volume 588, Issue 21, Pages 3878-3885
Publisher
Wiley
Online
2014-09-13
DOI
10.1016/j.febslet.2014.08.030
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Paralog Re-Emergence: A Novel, Historically Contingent Mechanism in the Evolution of Antimicrobial Resistance
- (2014) Nichola J. Hawkins et al. MOLECULAR BIOLOGY AND EVOLUTION
- Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease
- (2014) Israel Molina et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development
- (2014) Carolina B. Moraes et al. Scientific Reports
- In VitroandIn VivoStudies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi
- (2013) Maria de Nazaré Correia Soeiro et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?
- (2013) Galina I Lepesheva Expert Opinion on Drug Discovery
- Complexes ofTrypanosoma cruziSterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease
- (2013) Tatiana Y. Hargrove et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- VNI Cures Acute and Chronic Experimental Chagas Disease
- (2013) Fernando Villalta et al. JOURNAL OF INFECTIOUS DISEASES
- Characterization of the sterol 14α-demethylases ofFusarium graminearumidentifies a novel genus-specific CYP51 function
- (2013) Jieru Fan et al. NEW PHYTOLOGIST
- CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds
- (2012) Tatiana Y. Hargrove et al. International Journal for Parasitology-Drugs and Drug Resistance
- Sterol 14alpha-Demethylase (CYP51) as a Therapeutic Target for Human Trypanosomiasis and Leishmaniasis
- (2011) Galina I. Lepesheva et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) fromLeishmania infantum
- (2011) Tatiana Y. Hargrove et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural basis for conservation in the CYP51 family
- (2010) Galina I. Lepesheva et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human PathogenTrypanosoma cruzi
- (2010) Galina I. Lepesheva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chagas disease: pushing through the pipeline
- (2010) Julie Clayton NATURE
- Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections
- (2009) Galina I. Lepesheva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ergosterol biosynthesis and drug development for Chagas disease
- (2009) Julio A Urbina MEMORIAS DO INSTITUTO OSWALDO CRUZ
- Neglected Infections of Poverty in the United States of America
- (2008) Peter J. Hotez PLoS Neglected Tropical Diseases
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation