Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2

miR-98 delays skeletal muscle differentiation by down-regulating E2F5

(2015) Jeremie Kropp et al.   BIOCHEMICAL JOURNAL

LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans

(2015) Ho-Chou Tu et al.   GENES & DEVELOPMENT

Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy

(2014) Amy N. Dubinsky et al.   Cell Metabolism

Hmga2 regulates self-renewal of retinal progenitors

(2014) S. Parameswaran et al.   DEVELOPMENT

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

(2014) Hayley Davis et al.   NATURE MEDICINE

A Conditional System to Specifically Link Disruption of Protein-Coding Function with Reporter Expression in Mice

(2014) Shin-Heng Chiou et al.   Cell Reports

Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation

(2014) Nila Roy Choudhury et al.   Cell Reports

IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development

(2014) Lars Jønson et al.   Cell Reports

IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts

(2013) Kathryn E. Hamilton et al.   CARCINOGENESIS

WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer

(2013) Peter Wend et al.   EMBO Molecular Medicine

Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay

(2013) Fengchao Wang et al.   GASTROENTEROLOGY

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7

(2013) B. B. Madison et al.   GENES & DEVELOPMENT

Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts

(2013) A. M. Gurtan et al.   GENES & DEVELOPMENT

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

(2013) Michael R. Copley et al.   NATURE CELL BIOLOGY

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

Analysis of microRNA-target interactions across diverse cancer types

(2013) Anders Jacobsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

(2013) Jun-Hao Li et al.   NUCLEIC ACIDS RESEARCH

Distinct microRNA Expression Profile in Prostate Cancer Patients with Early Clinical Failure and the Impact of let-7 as Prognostic Marker in High-Risk Prostate Cancer

(2013) Maria Schubert et al.   PLoS One

Lin28B Is an Oncofetal Circulating Cancer Stem Cell-Like Marker Associated with Recurrence of Hepatocellular Carcinoma

(2013) Shu-Wen Cheng et al.   PLoS One

Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism

(2013) Gen Shinoda et al.   STEM CELLS

Exploring TCGA Pan-Cancer Data at the UCSC Cancer Genomics Browser

(2013) Melissa S. Cline et al.   Scientific Reports

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

(2013) Jarom Heijmans et al.   Cell Reports

A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties

(2013) Jinsuke Nishino et al.   eLife

High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer

(2012) R Hamano et al.   BRITISH JOURNAL OF CANCER

An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis

(2012) Zhizhong Li et al.   DEVELOPMENTAL CELL

Genome-wide analysis of HMGA2 transcription factor binding sites by ChIP on chip in gastric carcinoma cells

(2012) Lang Zha et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells

(2012) Amy Belton et al.   PLoS One

Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling

(2012) Y. Zong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

LIN28B Promotes Colon Cancer Progression and Metastasis

(2011) C. E. King et al.   CANCER RESEARCH

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers

(2011) X. Wang et al.   CLINICAL CANCER RESEARCH

LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms

(2011) C E King et al.   ONCOGENE

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro

(2010) Adam D. Gracz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo

(2009) I Lambertz et al.   CELL DEATH AND DIFFERENTIATION

Dicer1 functions as a haploinsufficient tumor suppressor

(2009) M. S. Kumar et al.   GENES & DEVELOPMENT

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Identification of Let-7-Regulated Oncofetal Genes

(2008) B. Boyerinas et al.   CANCER RESEARCH

Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

(2008) Jinsuke Nishino et al.   CELL

Clinical Significance of High Mobility Group A2 in Human Gastric Cancer and Its Relationship to let-7 MicroRNA Family

(2008) K. Motoyama et al.   CLINICAL CANCER RESEARCH

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

(2008) Elena Piskounova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiproliferative Effects by Let-7 Repression of High-Mobility Group A2 in Uterine Leiomyoma

(2008) Y. Peng et al.   MOLECULAR CANCER RESEARCH

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE