Article
Biochemistry & Molecular Biology
Xiaofei Ren, Kui Xu, Jianming Xu, Qiao Mei
Summary: Melatonin has therapeutic potential in monocrotaline-induced hepatic sinusoidal obstruction syndrome (HSOS). Administration of melatonin attenuates liver sinusoidal injury, oxidative stress, and dysfunction induced by MCT. The protective effect of melatonin on LSECs may be mediated by SIRT3 and MMP-9.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zhenli Liu, Shan Liang, Xinhuan Wei, Xiaofei Du, Jing Zhang
Summary: This study demonstrated that defibrotide could improve the outcome of pyrrolizidine alkaloids-induced rat hepatic sinusoidal obstruction syndrome, suggesting that defibrotide might be a better choice than low molecular weight heparin (LMWH) in clinical practice.
BMC GASTROENTEROLOGY
(2022)
Review
Pharmacology & Pharmacy
Chen Zhu, Xiuhua Ren, Dong Liu, Chengliang Zhang
Summary: This review summarized the epidemiology, pathological characteristics, clinical predictive indicators, related mechanisms, and possible prevention and treatment of oxaliplatin-related hepatic sinusoidal obstruction syndrome (HSOS).
Article
Biochemistry & Molecular Biology
Catherine M. Pastor, Valerie Vilgrain
Summary: Pyrrolizidine alkaloid monocrotaline induces sinusoidal obstruction syndrome and decreases biliary excretion of gadobenate dimeglumine. The changes in transporter function associated with sinusoidal obstruction syndrome may impact the pharmacokinetics of drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmet Poker, Musturay Karcaaltincaba, Mustafa N. Ozmen, Ali D. Karaosmanoglu, Ahmet G. Erdemir, Osman Ocal, Deniz Akata, Ilkay S. Idilman
Summary: This study evaluated the application of magnetic resonance elastography (MRE)-derived liver stiffness measurement (LSM), T1 and T2 relaxation times, and hepatobiliary phase images in diagnosing and assessing the severity of sinusoidal obstruction syndrome (SOS) after oxaliplatin-based chemotherapy. The results showed that MRE-LSM, T1, and T2 relaxation times were useful in diagnosing SOS, but were not effective in determining SOS severity.
INSIGHTS INTO IMAGING
(2022)
Article
Nutrition & Dietetics
Christina Decker, Reiner Krapf, Thomas Kuballa, Mirko Bunzel
Summary: Meat species of raw and processed meat products were accurately classified using H-1 NMR spectroscopy and multivariate data analysis. Different analytical methods were used to predict and identify the types of meat, with slightly lower accuracy for processed meat products. Classification using polar chemical markers was effective, and integrating data on polar and non-polar metabolites improved prediction accuracy.
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Xinmeng Chen, Jiang Ma, Yisheng He, Junyi Xue, Zijing Song, Qihe Xu, Ge Lin
Summary: This study provides experimental evidence regarding liver injury, liver fibrosis, and gene expression changes induced by Pyrrolizidine alkaloids (PAs) in rats.
Article
Oncology
Martin Stanulla, Elke Schaeffeler, Anja Moericke, Swantje Buchmann, Martin Zimmermann, Svitlana Igel, Kjeld Schmiegelow, Christian Flotho, Hans Hartmann, Sabine Illsinger, Axel Sauerbrey, Stefanie V. Junk, Peter Schuette, Laura Hinze, Melchior Lauten, Simon Modlich, Reinhard Kolb, Claudia Rossig, Georg Schwabe, Astrid K. Gnekow, Gudrun Fleischhack, Paul Gerhard Schlegel, Holger J. Schuenemann, Christian P. Kratz, Gunnar Cario, Martin Schrappe, Matthias Schwab
Summary: The study revealed that there is an increased risk of SOS in pediatric acute lymphoblastic leukemia patients after short-term exposure to 6-TG, especially in those with low-activity TPMT genotypes. Fortunately, all patients who developed SOS after short-term 6-TG treatment recovered without residual symptoms.
Article
Oncology
Sebastian Knitter, Gregor Duwe, Anika Sophie Beierle, Sina Pesthy, Paul Viktor Ritschl, Karl Herbert Hillebrandt, Alexander Arnold, Thomas Malinka, Dominik Paul Modest, Marcus Bahra, Johann Pratschke, Igor Maximilian Sauer, Moritz Schmelzle, Andreas Andreou
Summary: This study investigated the protective effects of inhibiting vascular endothelial growth factor (VEGF) on the development of sinusoidal obstruction syndrome (SOS) in mice with colorectal liver metastases (CLM) undergoing oxaliplatin-based chemotherapy. The results showed that VEGF inhibition reduced the incidence of SOS, potentially through changes in the VEGF pathway. This suggests that inhibiting VEGF may help reduce complications after liver resection in CLM patients. Further clinical studies are needed to confirm these findings.
Review
Medicine, General & Internal
Feifei Lu, Siqi Jia, Huiyuan Lu, Haonan Zhao, Zhe Li, Yuzheng Zhuge, Fernando Gomes Romeiro, Nahum Mendez-Sanchez, Xingshun Qi
Summary: This paper reviews the characteristics and differences between Budd-Chiari syndrome and sinusoidal obstruction syndrome, including the location of obstruction, complications, and treatment strategies.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Integrative & Complementary Medicine
Jiang Kai-Yuan, Zhang Yi, Ye Xuan-Ling, Xiong Fen, Chen Yan, Jia Xia-Li, Zhang Yi-Xin, Yang Li, Xiong Ai-Zhen, Wang Zheng-Tao
Summary: Bear bile powder (BBP) has a protective effect against hepatic sinusoidal obstruction syndrome (HSOS) induced by pyrrolizidine alkaloids (PAs), improving bile acid homeostasis, preventing liver fibrosis, and alleviating liver inflammation.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Gastroenterology & Hepatology
Samantha Thifani Alrutz Barcelos, Vincent Marin Dall'Oglio, Alexandre de Araujo, Carlos Thadeu Schmidt Cerski, Mario Reis Alvares-da-Silva
Summary: The case report describes a patient with hepatic sinusoidal obstruction syndrome (HSOS) caused by the intake of Senecio brasiliensis, highlighting the risk of liver injury with herbal intake.
ANNALS OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Li Yang, Xiaoping Xu, Zhiyuan Chen, Yu Zhang, Hui Chen, Xiangyang Wang
Summary: miR-511-3p is upregulated in both in vivo and in vitro models of HSOS. By targeting Ptch1, miR-511-3p activates the Hedgehog pathway. Knockdown of miR-511-3p demonstrates a protective effect against LSEC injury and apoptosis via the Hedgehog signaling pathway, with the inhibition of Ptch1 reversing this effect.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xunjiang Wang, Wei Zhang, Yongfeng Yang, Yiran Chen, Yuzheng Zhuge, Aizhen Xiong, Li Yang, Zhengtao Wang
Summary: This study identified three miRNAs (miR-148a-3p, miR-362-5p, and miR-194-5p) that were overexpressed in PA-induced HSOS and showed potential as biomarkers, with good diagnostic accuracy for patients with HSOS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Yicong Li, Shuangxi Fan, Anjun Li, Guoying Liu, Wei Lu, Bo Yang, Fengxian Wang, Xin Zhang, Xiaojuan Gao, Zhiyuan Lu, Ning Su, Guanghao Wang, Yinuo Liu, Xin Ji, Peng Xin, Guohui Li, Daobing Wang, Fuping Lu, Qiding Zhong
Summary: This study utilized NMR and GC analysis combined with multivariate statistical analysis to establish a model for validating the vintage authenticity of Chinese Baijiu, providing important evidence for distinguishing actual storage vintages.
Article
Critical Care Medicine
[Anonymous]
ANNALS OF INTENSIVE CARE
(2016)
Article
Oncology
Vincent Richard, Raphael Conotte, David Mayne, Jean-Marie Colet
Article
Physiology
Stephanie Conotte, Alexandra Tassin, Raphael Conotte, Jean-Marie Colet, Karim Zouaoui Boudjeltia, Alexandre Legrand
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2018)
Article
Chemistry, Medicinal
Jalal Soubhye, Iyas Aldib, Betina Elfving, Michel Gelbcke, Paul G. Furtmueller, Manuel Podrecca, Raphael Conotte, Jean-Marie Colet, Alexandre Rousseau, Florence Reye, Ahmad Sarakbi, Michel Vanhaeyerbeek, Jean-Michel Kauffmann, Christian Obinger, Jean Neve, Martine Prevost, Karim Zouaoui Boudjeltia, Francois Dufrasne, Pierre Van Antwerpen
JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Analytical
S. Hambye, M. Helvenstein, L. Verdy, Z. Kahvecioglu, R. Conotte, J. -J. Vanden Eynde, J. -M. Colet, B. Blankert
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2014)
Article
Pharmacology & Pharmacy
Jalal Soubhye, Iyas Aldib, Martine Prevost, Betina Elfving, Michel Gelbcke, Manuel Podrecca, Raphael Conotte, Jean-Marie Colet, Paul G. Furtmueller, Cedric Delporte, Alexandre Rousseau, Michel Vanhaeverbeek, Jean Neve, Christian Obinger, Karim Zouaoui-Boudjeltia, Pierre Van Antwerpen, Francois Dufrasne
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Aurelie Thooft, Raphael Conotte, Jean-Marie Colet, Karim Zouaoui Boudjeltia, Patrick Biston, Michael Piagnerelli
Summary: Inflammatory processes in ICU patients can lead to metabolic changes and increased risks of morbidity and mortality. This study aimed to determine if metabolomics can aid in prognosis at ICU admission. Metabolic profiles of ICU patients were compared to healthy volunteers, and differences were found in septic shock patients. However, these metabolite profiles were not correlated with mortality. Changes in metabolic products were observed in septic shock patients on the first day of ICU admission, but these changes did not predict prognosis.