Article
Immunology
Youngae Lee, Jang-Hee Oh, Na Li, Hyun-Jae Jang, Kyung-Seop Ahn, Sei-Ryang Oh, Dong Hun Lee, Jin Ho Chung
Summary: SFII demonstrated anti-inflammatory effects in atopic dermatitis therapy, effectively suppressing inflammation, cytokine production, and cell infiltration, indicating therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Raquel Freitas Zambonatto, Renata Nakata Teixeira, Sarah de Oliveira Poma, Eliane Borges da Silva, Mariana Mendes de Almeida, Gerson dos Santos Leite, Cesar Miguel Momesso dos Santos, Heloisa Helena de Oliveira Alves, Renata Gorjao, Tania Cristina Pithon-Curi, Celso R. F. Carvalho, Rui Curi, Adriana Cristina Levada-Pires
Summary: The study found that neutrophils from atopic elite runners exhibited lower responses to LPS stimulation compared to non-atopic runners. Both groups responded similarly to fMLP stimulation. Training hours and volume were not associated with neutrophil function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tina De Bruyn Carlier, Fariza Mishaal Saiema Badloe, Johannes Ring, Jan Gutermuth, Inge Kortekaas Krohn
Summary: Atopic dermatitis is a chronic inflammatory skin disease that develops in early childhood and is associated with food allergy, with immune reactions potentially leading to autoimmune processes. The exact mechanisms of IgE-mediated autoimmunity and self-reactive T cells in the pathophysiology of AD are still unclear.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Immunology
Melanie Humeau, Katia Boniface, Charles Bodet
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dysregulated immune response and increased colonization of Staphylococcus aureus. The interaction between T cells and keratinocytes through cytokine release plays a key role in AD pathogenesis, with potential impact from virulence factors produced by Staphylococcus aureus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Rong Wang, Haruyo Nakajima-Adachi, Yimei Wang, Yingyu Zhou, Wenting Gu, Erika Hiraide, Mamiko Morinaga, Ryogo Nakagawa, Shotaro Nakamura, Tomohiro Takano, Xuyang Li, Mayumi Saeki, Osamu Kaminuma, Takachika Hiroi, Kenji Uchida, Hidemasa Motoshima, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Lactococcus lactis subsp. cremoris YRC3780 isolated from kefir has anti-allergic effects in humans. The oral administration of L. cremoris YRC3780 enhanced IFN-gamma and IL-12 production, inhibited IL-4 production, and attenuated symptoms in an atopic dermatitis mouse model by regulating cytokine expression.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Pharmacology & Pharmacy
Vivi Nur Khalieda Mohd Kasim, Siti Mahirah Noble, Kong Yen Liew, Ji Wei Tan, Daud Ahmad Israf, Chau Ling Tham
Summary: This systematic review summarizes 103 articles on the use of orally and topically administered herbs and their active constituents in a murine model for the management of atopic dermatitis (AD). The majority of the studies showed that these herbs and their active constituents can suppress the immune response, improve the severity of AD lesions, and reduce IgE concentration and mast cell infiltration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Allergy
Inge Kortekaas Krohn, Fariza Mishaal Saiema Badloe, Nadine Herrmann, Laura Maintz, Shauni De Vriese, Johannes Ring, Jan CK-CARE Study Group, Thomas Bieber, Jan Gutermuth
Summary: Autoreactive IgE antibodies to self-peptides within the epidermis have been identified in patients with atopic dermatitis (AD). The presence of IgE autoantibodies seems to be associated with atopic comorbidities and environmental factors. These findings suggest the potential value of IgE autoantibodies as a predictive biomarker for the course of AD and the atopic march.
Article
Medicine, Research & Experimental
Songwen Ren, You Gao, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang, Chengyong He
Summary: The study demonstrated that Sacran could alleviate symptoms in AD mice, reduce skin inflammation induced by DNCB, potentially through inhibiting Th2 cell activation and decreasing IgE release.
Review
Dermatology
Shuyun Yang, Tingting Zhu, Joan S. S. Wakefield, Theodora M. M. Mauro, Peter M. M. Elias, Mao-Qiang Man
Summary: Two serious health conditions, obesity and atopic dermatitis (AD), share pathological features and evidence suggests a link between them. Obesity can predispose and worsen AD, while AD increases the risk of obesity. Cytokines, chemokines, and immune cells mediate the interactions between obesity and AD. Weight loss can alleviate AD, but obese individuals with AD are more resistant to anti-inflammatory therapy. Effective management and further studies are needed to validate the connection and explore mitigation strategies.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Meriam Belghith, Olfa Maghrebi, Aroua Cherif, Khadija Bahrini, Zakaria Saied, Samir Belal, Samia Ben Sassi, Mohamed-Ridha Barbouche, Mariem Kchaou
Summary: When the primary affected site of Behcet's disease is the central nervous system (CNS), the diagnosis becomes more challenging. This study found differential expression patterns of cytokines and transcription factors in patients with neuro-Behcet's disease. Additionally, it identified a disrupted balance between Th17 effector and T regulatory cells as an additional criterion for definite neuro-Behcet's disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Lidia Sans-de San Nicolas, Ignasi Figueras-Nart, Irene Garcia-Jimenez, Montserrat Bonfill-Orti, Antonio Guilabert, Laia Curto-Barredo, Marta Bertolin-Colilla, Marta Ferran, Esther Serra-Baldrich, Ramon M. Pujol, Luis F. Santamaria-Babi
Summary: This study found that memory T cells from AD patients sensitized to house dust mite produce IL-31, and the production of IL-31 is related to the clinical features of the patients. The production of IL-31 is associated with patient's pruritus intensity, plasma CCL27 levels, and periostin levels. By measuring the levels of sp IgE and total IgE, IL-31 production and related clinical phenotypes can be further determined.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mariam M. Amin, Hossam M. Elkady
Summary: This study investigated the sensitization to aeroallergens in 132 patients with atopic dermatitis and found that multiple aeroallergens can worsen the severity of the disease.
Article
Immunology
Alicja Majewska, Kourou Dembele, Katarzyna Dziendzikowska, Adam Prostek, Malgorzata Gajewska
Summary: This study observed the effect of allergen-specific immunotherapy on canine atopic dermatitis patients. The results showed that immunotherapy can reduce cytokine levels, alter the numbers of specific T cell subpopulations, and have an impact on regulatory T cells.
Article
Biochemistry & Molecular Biology
Tianheng Hou, Miranda Sin-Man Tsang, Lea Ling-Yu Kan, Peiting Li, Ida Miu-Ting Chu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: IL-37b has been shown to regulate basophil activation mediated by TSLP and reduce the release of IL-4, suggesting its potential as a target for alleviating symptoms of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Haiping Jia, Huiying Wan, Dingding Zhang
Summary: Atopic dermatitis is a common allergic inflammatory skin condition caused by gene variants, immune disorders, and environmental risk factors. The immune response mediated by T helper 2 cells is believed to play a central role in the pathogenesis of atopic dermatitis. Innate lymphoid cells, especially ILC2s, have been shown to have a significant impact on tissue homeostasis and inflammation. However, the specific role of ILCs in atopic dermatitis still requires further investigation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Jisung Kim, Siyoung Lee, Bo-Ryoung Choi, Hee Yang, Youjin Hwang, Jung Han Yoon Park, Frank M. LaFerla, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
MOLECULAR NUTRITION & FOOD RESEARCH
(2017)
Article
Chemistry, Medicinal
Ji Yeon Seo, Soon Sung Lim, Jiyoung Kim, Ki Won Lee, Jong-Sang Kim
PHYTOTHERAPY RESEARCH
(2017)
Article
Endocrinology & Metabolism
Jaekyoon Kim, Karyn M. Frick
PSYCHONEUROENDOCRINOLOGY
(2017)
Review
Behavioral Sciences
Karyn M. Frick, Jaekyoon Kim
HORMONES AND BEHAVIOR
(2018)
Article
Chemistry, Medicinal
Alicia M. Hanson, K. L. Iresha Sampathi Perera, Jaekyoon Kim, Rajesh K. Pandey, Noreena Sweeney, Xingyun Lu, Andrea Imhoff, Alexander Craig Mackinnon, Adam J. Wargolet, Rochelle M. Van Hart, Karyn M. Frick, William A. Donaldson, Daniel S. Sem
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Food Science & Technology
Siyoung Lee, Bo-Ryoung Choi, Jisung Kim, Frank M. LaFerla, Jung Han Yoon Park, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Article
Psychology, Biological
Karyn M. Frick, Jennifer J. Tuscher, Wendy A. Koss, Jaekyoon Kim, Lisa R. Taxier
PHYSIOLOGY & BEHAVIOR
(2018)
Article
Neurosciences
Jaekyoon Kim, Jayson C. Schalk, Wendy A. Koss, Rachel L. Gremminger, Lisa R. Taxier, Kellie S. Gross, Karyn M. Frick
JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
HUMAN MOLECULAR GENETICS
(2020)
Review
Biochemistry & Molecular Biology
Jiyoung Kim
Summary: Sulforaphane, a bioactive compound from cruciferous vegetables, has been extensively studied for its potential in disease prevention, particularly in anti-carcinogenic properties. Clinical trials are ongoing to investigate its effects on various cancers, asthma, skin aging, dermatitis, and obesity. Recent research also suggests potential protective effects of sulforaphane on brain health and neurodegenerative diseases like Alzheimer's and Parkinson's.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juyong Kim, Sangwoo Seo, Jung Han Yoon Park, Ki Won Lee, Jiyoung Kim, Jin-Chul Kim
Summary: TRPV1 deficiency exhibits neuroprotective effects by preventing apoptosis through the BDNF/CREB signal transduction pathway in the hippocampus of 3xTg-AD mice.
MOLECULES AND CELLS
(2023)
Article
Medicine, General & Internal
Il-Han Yoo, Myung-Jin Kim, Jiyoung Kim, Jung-Joon Sung, Sung Taek Park, Suk-Won Ahn
JOURNAL OF KOREAN MEDICAL SCIENCE
(2019)
Review
Behavioral Sciences
Karyn M. Frick, Jaekyoon Kim, Wendy A. Koss
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Ah Young Lee, Jae Won Lee, Ji-Eun Kim, Hyuck Jun Mock, Sungjin Park, Sanghwa Kim, Seong-Ho Hong, Ji-Young Kim, Eun-Jung Park, Kyung-Sun Kang, Kwang Pyo Kim, Myung-Haing Cho
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Medicine, Research & Experimental
Ji Ae Lee, Hye Ri Kim, Jiyoung Kim, Ki Duk Park, Dong Jin Kim, Onyou Hwang
EXPERIMENTAL NEUROBIOLOGY
(2018)