Journal
HORMONES AND BEHAVIOR
Volume 104, Issue -, Pages 100-110Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2018.04.013
Keywords
Mouse; Object recognition; Object placement; Cell signaling; ERK; mTOR; Histone acetylation; Spines
Categories
Funding
- National Institutes of Health [R01AG022525, R01MH107886, R03MH065460]
- University of Wisconsin-Milwaukee
- American Federation for Aging Research
- Ellison Medical Foundation
- Yale University
- University of Wisconsin-Milwaukee Research Growth Initiative Awards [101X240, 101X334]
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Contribution to Special Issue on Fast effects of steroids. Although rapid effects of 17 beta-estradiol (E2) and progesterone on cellular functions have been observed for several decades, a proliferation of data in recent years has demonstrated the importance of these actions to cognition. In particular, an emerging literature has demonstrated that these hormones promote the consolidation of spatial and object recognition memories in rodents via rapid activation of numerous cellular events including cell signaling, histone modifications, and local protein translation in the hippocampus. This article provides an overview of the evidence demonstrating that E2 and progesterone enhance hippocampal memory consolidation in female rodents, and then discusses numerous molecular mechanisms thus far shown to mediate the beneficial effects of these hormones on memory formation.
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