Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

RCytoscape: tools for exploratory network analysis

(2013) Paul T Shannon et al.   BMC BIOINFORMATICS

Neural crest-derived cells sustain their multipotency even after entry into their target tissues

(2013) Tsutomu Motohashi et al.   DEVELOPMENTAL DYNAMICS

Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells

(2013) Kamaraj Sattu et al.   FEBS Journal

SH3 interactome conserves general function over specific form

(2013) X. Xin et al.   Molecular Systems Biology

Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line

(2013) J DeWitt et al.   ONCOGENE

Wrangling Phosphoproteomic Data to Elucidate Cancer Signaling Pathways

(2013) Mark L. Grimes et al.   PLoS One

Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

(2013) Ramesh Narayanan et al.   PLoS One

Quantitative Phosphoproteomic Analysis Identifies Activation of the RET and IGF-1R/IR Signaling Pathways in Neuroblastoma

(2013) Bradley D. DeNardo et al.   PLoS One

The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells

(2013) A. S. Meyer et al.   Science Signaling

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

Consecutive Proteolytic Digestion in an Enzyme Reactor Increases Depth of Proteomic and Phosphoproteomic Analysis

(2012) Jacek R. Wiśniewski et al.   ANALYTICAL CHEMISTRY

Mass Spectrometry–Based Proteomics and Network Biology

(2012) Ariel Bensimon et al.   Annual Review of Biochemistry

Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells

(2012) Jian Chen et al.   CELL

The neural crest in vertebrate evolution

(2012) Nicole M Le Douarin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Stem cell maintenance in the adult mammalian hippocampus: A matter of signal integration?

(2012) Tobias J. Schwarz et al.   Developmental Neurobiology

Domain-mediated protein interaction prediction: From genome to network

(2012) Jüri Reimand et al.   FEBS LETTERS

TiSH — a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

(2012) Kasper Engholm-Keller et al.   Journal of Proteomics

PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS

(2012) Matthew P. Stokes et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeting ALK in neuroblastoma—preclinical and clinical advancements

(2012) Erica L. Carpenter et al.   Nature Reviews Clinical Oncology

Modular evolution of phosphorylation-based signalling systems

(2012) J. Jin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Evolution of SH2 domains and phosphotyrosine signalling networks

(2012) B. A. Liu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts

(2012) Shona Pryor et al.   PLoS One

Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA

(2012) Y. Mei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

(2012) J. M. Drake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining many interaction networks to predict gene function and analyze gene lists

(2012) Sara Mostafavi et al.   PROTEOMICS

Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges

(2012) Purvesh Khatri et al.   PLoS Computational Biology

ROR1 and ROR2 in Human Malignancies: Potentials for Targeted Therapy

(2012) Guilly Rebagay et al.   Frontiers in Oncology

Increasing phosphoproteomic coverage through sequential digestion by complementary proteases

(2011) Jason M. Gilmore et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The effect of P75 on Trk receptors in neuroblastomas

(2011) Ruth Ho et al.   CANCER LETTERS

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

A perspective on non-catalytic Src homology (SH) adaptor signalling proteins

(2011) Vikash Reebye et al.   CELLULAR SIGNALLING

Signaling circuitries controlling stem cell fate: to be or not to be

(2011) Ramiro Iglesias-Bartolome et al.   CURRENT OPINION IN CELL BIOLOGY

Neural crest cells retain their capability for multipotential differentiation even after lineage-restricted stages

(2011) Tsutomu Motohashi et al.   DEVELOPMENTAL DYNAMICS

Ultra High Resolution Linear Ion Trap Orbitrap Mass Spectrometer (Orbitrap Elite) Facilitates Top Down LC MS/MS and Versatile Peptide Fragmentation Modes

(2011) Annette Michalski et al.   MOLECULAR & CELLULAR PROTEOMICS

Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis

(2011) Renu Goel et al.   Molecular BioSystems

A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision

(2011) Jia-Yun Chen et al.   MOLECULAR CELL

The dissimilarity space: Bridging structural and statistical pattern recognition

(2011) Robert P.W. Duin et al.   PATTERN RECOGNITION LETTERS

Clinical significance of NTRK family gene expression in neuroblastomas

(2011) Jennifer E. Light et al.   PEDIATRIC BLOOD & CANCER

The Host Range of Gammaretroviruses and Gammaretroviral Vectors Includes Post-Mitotic Neural Cells

(2011) Xiu-Huai Liu et al.   PLoS One

Global Phosphoproteomics Reveals Crosstalk Between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling

(2011) L. Rubbi et al.   Science Signaling

Neuroblastoma aggressiveness in relation to sympathetic neuronal differentiation stage

(2011) Sofie A. Mohlin et al.   SEMINARS IN CANCER BIOLOGY

The MYCN oncogene and differentiation in neuroblastoma

(2011) Ulrica K. Westermark et al.   SEMINARS IN CANCER BIOLOGY

Building and analyzing protein interactome networks by cross-species comparisons

(2010) Amy M Wiles et al.   BMC Systems Biology

Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens

(2010) Kristen M. Smith et al.   EMBO Molecular Medicine

Neuroblastoma Phox2b Variants Stimulate Proliferation and Dedifferentiation of Immature Sympathetic Neurons

(2010) T. Reiff et al.   JOURNAL OF NEUROSCIENCE

Visualization of omics data for systems biology

(2010) Nils Gehlenborg et al.   NATURE METHODS

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Molecular pathogenesis of peripheral neuroblastic tumors

(2010) I Janoueix-Lerosey et al.   ONCOGENE

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

The migration of autonomic precursor cells in the embryo

(2009) Paul M. Kulesa et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

Trk Receptor Expression and Inhibition in Neuroblastomas

(2009) G. M. Brodeur et al.   CLINICAL CANCER RESEARCH

ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction

(2009) Joffrey Degoutin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A unifying view of 21st century systems biology

(2009) Marc Vidal   FEBS LETTERS

Exploring nonlinear feature space dimension reduction and data representation in breast CADx with Laplacian eigenmaps and t-SNE

(2009) Andrew R. Jamieson et al.   MEDICAL PHYSICS

Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death

(2009) J. R. Pritchard et al.   MOLECULAR CANCER THERAPEUTICS

Protein acylation and localization in T cell signaling (Review)

(2009) Marie-José Bijlmakers   MOLECULAR MEMBRANE BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Positive Selection of Tyrosine Loss in Metazoan Evolution

(2009) C. S. H. Tan et al.   SCIENCE

Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

(2009) A. Bertotti et al.   Science Signaling

High-Resolution Fractionation of Signaling Endosomes Containing Different Receptors

(2009) Gretchen McCaffrey et al.   TRAFFIC

Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

(2009) Kirstine Roepstorff et al.   TRAFFIC

Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins

(2009) Raffi Tonikian et al.   PLOS BIOLOGY

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

(2008) Helena Carén et al.   BIOCHEMICAL JOURNAL

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

Differential subcellular membrane recruitment of Src may specify its downstream signalling

(2008) Philippe de Diesbach et al.   EXPERIMENTAL CELL RESEARCH

Endocytosis and intracellular trafficking of ErbBs

(2008) Alexander Sorkin et al.   EXPERIMENTAL CELL RESEARCH

The Lipid Raft-Anchored Adaptor Protein Cbp Controls the Oncogenic Potential of c-Src

(2008) Chitose Oneyama et al.   MOLECULAR CELL

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

Activating mutations in ALK provide a therapeutic target in neuroblastoma

(2008) Rani E. George et al.   NATURE

Oncogenic mutations of ALK kinase in neuroblastoma

(2008) Yuyan Chen et al.   NATURE

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

(2008) Isabelle Janoueix-Lerosey et al.   NATURE

STRING 8--a global view on proteins and their functional interactions in 630 organisms

(2008) L. J. Jensen et al.   NUCLEIC ACIDS RESEARCH

Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages

(2008) D. Pincus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling networks assembled by oncogenic EGFR and c-Met

(2008) A. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Src family kinases: Regulation of their activities, levels and identification of new pathways

(2007) Evan Ingley   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

(2007) Marie Dance et al.   CELLULAR SIGNALLING