Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments
Authors
Keywords
Molecular dynamics, Antibodies, Entropy, Somatic mutation, Esterases, Antigens, Free energy, Sequence alignment
Journal
PLoS Computational Biology
Volume 11, Issue 7, Pages e1004327
Publisher
Public Library of Science (PLoS)
Online
2015-07-02
DOI
10.1371/journal.pcbi.1004327
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Backbone Flexibility of CDR3 and Immune Recognition of Antigens
- (2014) Jaafar N. Haidar et al. JOURNAL OF MOLECULAR BIOLOGY
- Redistribution of Flexibility in Stabilizing Antibody Fragment Mutants Follows Le Châtelier’s Principle
- (2014) Tong Li et al. PLoS One
- OptMAVEn – A New Framework for the de novo Design of Antibody Variable Region Models Targeting Specific Antigen Epitopes
- (2014) Tong Li et al. PLoS One
- Thermodynamic Stability and Flexibility Characteristics of Antibody Fragment Complexes
- (2014) Tong Li et al. PROTEIN AND PEPTIDE LETTERS
- Cation-π, amino-π, π-π, and H-bond interactions stabilize antigen-antibody interfaces
- (2014) Georgios A. Dalkas et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
- (2013) Sander Pronk et al. BIOINFORMATICS
- MAPs: a database of modular antibody parts for predicting tertiary structures and designing affinity matured antibodies
- (2013) Robert J Pantazes et al. BMC BIOINFORMATICS
- Energetic and Dynamic Aspects of the Affinity Maturation Process: Characterizing Improved Variants from the Bevacizumab Antibody with Molecular Simulations
- (2013) Dario Corrada et al. Journal of Chemical Information and Modeling
- Antibody Polyreactivity in Health and Disease: Statu Variabilis
- (2013) J. D. Dimitrov et al. JOURNAL OF IMMUNOLOGY
- Conformational Selection and Induced Fit in Specific Antibody and Antigen Recognition: SPE7 as a Case Study
- (2013) Wei Wang et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations
- (2013) Ekaterine Kortkhonjia et al. mAbs
- Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation
- (2013) Feng Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Engineering a More Thermostable Blue Light Photo Receptor Bacillus subtilis YtvA LOV Domain by a Computer Aided Rational Design Method
- (2013) Xiangfei Song et al. PLoS Computational Biology
- Human Germline Antibody Gene Segments Encode Polyspecific Antibodies
- (2013) Jordan R. Willis et al. PLoS Computational Biology
- Variations within Class-A β-Lactamase Physiochemical Properties Reflect Evolutionary and Environmental Patterns, but not Antibiotic Specificity
- (2013) Deeptak Verma et al. PLoS Computational Biology
- Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface
- (2012) Chung-Ming Yu et al. PLoS One
- Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody
- (2012) A. G. Schmidt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged
- (2012) Deeptak Verma et al. PLoS Computational Biology
- Nonadditivity in Conformational Entropy upon Molecular Rigidification Reveals a Universal Mechanism Affecting Folding Cooperativity
- (2011) Oleg K. Vorov et al. BIOPHYSICAL JOURNAL
- Predicting the Melting Point of Human C-Type Lysozyme Mutants
- (2011) Deeptak Verma et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates
- (2010) Roy A. Mariuzza et al. BIOLOGICAL CHEMISTRY
- Allosteric Response Is both Conserved and Variable across Three CheY Orthologs
- (2010) James M. Mottonen et al. BIOPHYSICAL JOURNAL
- Molecular Description of Flexibility in an Antibody Combining Site
- (2010) Jörg Zimmermann et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Evolving concepts of specificity in immune reactions
- (2010) H. N. Eisen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein rigidity and thermophilic adaptation
- (2010) Sebastian Radestock et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Helix/Coil Nucleation: A Local Response to Global Demands
- (2009) Oleg K. Vorov et al. BIOPHYSICAL JOURNAL
- Improved prediction of protein side-chain conformations with SCWRL4
- (2009) Georgii G. Krivov et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Hydrogen bond networks determine emergent mechanical and thermodynamic properties across a protein family
- (2008) Dennis R Livesay et al. Chemistry Central Journal
- Affinity maturation of antibodies assisted byin silicomodeling
- (2008) Rodrigo Barderas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unifying mechanical and thermodynamic descriptions across the thioredoxin protein family
- (2008) James M. Mottonen et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility
- (2008) Mariana Babor et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies
- (2007) Roxana M. Ionescu et al. JOURNAL OF PHARMACEUTICAL SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now