Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

The Design of Covalent Allosteric Drugs

(2015) Ruth Nussinov et al.   Annual Review of Pharmacology and Toxicology

Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors

(2015) Geoffrey C. Li et al.   BIOCHEMISTRY

Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling

(2015) Srinath Krishnamurthy et al.   BIOPHYSICAL JOURNAL

Allostery without a conformational change? Revisiting the paradigm

(2015) Ruth Nussinov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels

(2015) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Membrane Mimetics on Cytochrome P450-Cytochromeb5Interactions Characterized by NMR Spectroscopy

(2015) Meng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

(2015) Mohammad T. Mazhab-Jafari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery through the computational microscope: cAMP activation of a canonical signalling domain

(2015) Robert D. Malmstrom et al.   Nature Communications

Insights into the Role of Substrates on the Interaction between Cytochrome b5 and Cytochrome P450 2B4 by NMR

(2015) Meng Zhang et al.   Scientific Reports

Bridging scales through multiscale modeling: a case study on protein kinase A

(2015) Britton W. Boras et al.   Frontiers in Physiology

Allosteric linkers in cAMP signalling

(2014) Madoka Akimoto et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR

(2014) Stephen Boulton et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Isomerase-Catalyzed Binding of Interleukin-1 Receptor-Associated Kinase 1 to the EVH1 Domain of Vasodilator-Stimulated Phosphoprotein

(2014) Alexander I. Greenwood et al.   BIOCHEMISTRY

Active Site Coupling in PDE:PKA Complexes Promotes Resetting of Mammalian cAMP Signaling

(2014) Srinath Krishnamurthy et al.   BIOPHYSICAL JOURNAL

Signaling at Crossroads: The Dialogue between PDEs and PKA is Spoken in Multiple Languages

(2014) Kody Moleschi et al.   BIOPHYSICAL JOURNAL

Protein Kinase A Alterations in Adrenocortical Tumors

(2014) S. Espiard et al.   HORMONE AND METABOLIC RESEARCH

Kinetic and Structural Characterization of the Interaction between the FMN Binding Domain of Cytochrome P450 Reductase and Cytochromec

(2014) Rui Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP

(2014) Madoka Akimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using Markov State Models to Develop a Mechanistic Understanding of Protein Kinase A Regulatory Subunit RIα Activation in Response to cAMP Binding

(2014) Britton W. Boras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles of Allosteric Interactions in Cell Signaling

(2014) Ruth Nussinov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrated RAS signaling defined by parallel NMR detection of effectors and regulators

(2014) Matthew J Smith et al.   Nature Chemical Biology

Synchronous Opening and Closing Motions Are Essential for cAMP-Dependent Protein Kinase A Signaling

(2014) Atul K. Srivastava et al.   STRUCTURE

Signaling through dynamic linkers as revealed by PKA

(2013) M. Akimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Projection Analysis of NMR Chemical Shifts Reveals Extended EPAC Autoinhibition Determinants

(2012) Rajeevan Selvaratnam et al.   BIOPHYSICAL JOURNAL

PRKAR1AMutation Affecting cAMP-Mediated G Protein-Coupled Receptor Signaling in a Patient with Acrodysostosis and Hormone Resistance

(2012) Keisuke Nagasaki et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR

(2012) J. L. Lorieau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RecurrentPRKAR1AMutation in Acrodysostosis with Hormone Resistance

(2011) Agnès Linglart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Communication between Tandem cAMP Binding Domains in the Regulatory Subunit of Protein Kinase A-Iα as Revealed by Domain-silencing Mutations

(2010) E. Tyler McNicholl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Communication between cAMP Binding Sites in the RI Subunit of Protein Kinase A Revealed by NMR

(2010) In-Ja L. Byeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The twist in Crk signaling revealed

(2010) Linda K Nicholson et al.   Nature Chemical Biology

Dissecting the cAMP-inducible allosteric switch in protein kinase A RIα

(2010) Timothy J. Sjoberg et al.   PROTEIN SCIENCE

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering

(2009) Cecilia Y. Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

(2008) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY