Topography Design Concept of a Tissue Engineering Scaffold for Controlling Cell Function and Fate Through Actin Cytoskeletal Modulation

Expression of Oct4 in human embryonic stem cells is dependent on nanotopographical configuration

(2013) Yen P. Kong et al.   Acta Biomaterialia

Three-dimensional modulation of cortical plasticity during pseudopodial protrusion of mouse leukocytes

(2013) Hiromi Miyoshi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular Response to Substrate Rigidity Is Governed by Either Stress or Strain

(2013) Ai Kia Yip et al.   BIOPHYSICAL JOURNAL

Scaling of Dorsal-Ventral Patterning by Embryo Size-Dependent Degradation of Spemann’s Organizer Signals

(2013) Hidehiko Inomata et al.   CELL

Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules

(2013) Douglas G. Brownfield et al.   CURRENT BIOLOGY

PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively

(2013) Wenting Zhu et al.   DEVELOPMENTAL BIOLOGY

Actin filament dynamics impacts keratinocyte stem cell maintenance

(2013) Daisuke Nanba et al.   EMBO Molecular Medicine

Mesenchymal stem cell mechanobiology and emerging experimental platforms

(2013) L. MacQueen et al.   Journal of the Royal Society Interface

Visualization of an endogenous retinoic acid gradient across embryonic development

(2013) Satoshi Shimozono et al.   NATURE

Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions

(2013) Melda Tozluoğlu et al.   NATURE CELL BIOLOGY

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Modulating the Actin Cytoskeleton Affects Mechanically Induced Signal Transduction and Differentiation in Mesenchymal Stem Cells

(2013) Petra Müller et al.   PLoS One

How vinculin regulates force transmission

(2013) D. W. Dumbauld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues

(2013) N. Thavandiran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deconstructing Dimensionality

(2013) M. A. Schwartz et al.   SCIENCE

Bone Regeneration by the Osteoconductivity of Porous Titanium Implants Manufactured by Selective Laser Melting: A Histological and Micro Computed Tomography Study in the Rabbit

(2013) Michael de Wild et al.   TISSUE ENGINEERING PART A

Selective modulation of cell response on engineered fractal silicon substrates

(2013) Francesco Gentile et al.   Scientific Reports

Mechanical Regulation of Nuclear Structure and Function

(2012) Rui P. Martins et al.   Annual Review of Biomedical Engineering

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Self-renewal of embryonic stem cells through culture on nanopattern polydimethylsiloxane substrate

(2012) Kilsoo Jeon et al.   BIOMATERIALS

Nanotopography as modulator of human mesenchymal stem cell function

(2012) Karina Kulangara et al.   BIOMATERIALS

Long-term maintenance of mouse embryonic stem cell pluripotency by manipulating integrin signaling within 3D scaffolds without active Stat3

(2012) Seung Tae Lee et al.   BIOMATERIALS

High content imaging in the screening of biomaterial-induced MSC behavior

(2012) H.V. Unadkat et al.   BIOMATERIALS

Directing cell migration in continuous microchannels by topographical amplification of natural directional persistence

(2012) Young-Gwang Ko et al.   BIOMATERIALS

Force-Induced Changes in Subnuclear Movement and Rheology

(2012) Elizabeth A. Booth-Gauthier et al.   BIOPHYSICAL JOURNAL

Mechanical Activation of Cells Induces Chromatin Remodeling Preceding MKL Nuclear Transport

(2012) K. Venkatesan Iyer et al.   BIOPHYSICAL JOURNAL

Mechanical control of integrin-mediated adhesion and signaling

(2012) David Boettiger   CURRENT OPINION IN CELL BIOLOGY

Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro

(2012) George Kensah et al.   EUROPEAN HEART JOURNAL

Cyclic mechanical strain maintains Nanog expression through PI3K/Akt signaling in mouse embryonic stem cells

(2012) Rie Horiuchi et al.   EXPERIMENTAL CELL RESEARCH

Spatiotemporal coordinated hierarchical properties of cellular protrusion revealed by multiscale analysis

(2012) Hiromi Miyoshi et al.   Integrative Biology

Fine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes

(2012) Maël Le Berre et al.   Integrative Biology

Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model

(2012) Hiroshi Kamioka et al.   Integrative Biology

Control of stem cell fate and function by engineering physical microenvironments

(2012) Kshitiz et al.   Integrative Biology

Mechanobiology: a new frontier for human pluripotent stem cells

(2012) Yubing Sun et al.   Integrative Biology

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

Matrix nanotopography as a regulator of cell function

(2012) Deok-Ho Kim et al.   JOURNAL OF CELL BIOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status

(2012) S. E. Le Devedec et al.   JOURNAL OF CELL SCIENCE

Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension

(2012) S. R. Coyer et al.   JOURNAL OF CELL SCIENCE

Matrix stiffness reverses the effect of actomyosin tension on cell proliferation

(2012) J. D. Mih et al.   JOURNAL OF CELL SCIENCE

Mechanosensitive mechanisms in transcriptional regulation

(2012) Akiko Mammoto et al.   JOURNAL OF CELL SCIENCE

Determinants of cell-material crosstalk at the interface: towards engineering of cell instructive materials

(2012) M. Ventre et al.   Journal of the Royal Society Interface

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vivo directed differentiation of pluripotent stem cells for skeletal regeneration

(2012) B. Levi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cells test substrate rigidity by local contractions on submicrometer pillars

(2012) S. Ghassemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microarray with Micro- and Nano-topographies Enables Identification of the Optimal Topography for Directing the Differentiation of Primary Murine Neural Progenitor Cells

(2012) Aung Aung Kywe Moe et al.   Small

Cytoskeletal and Focal Adhesion Influences on Mesenchymal Stem Cell Shape, Mechanical Properties, and Differentiation Down Osteogenic, Adipogenic, and Chondrogenic Pathways

(2012) Pattie S. Mathieu et al.   TISSUE ENGINEERING PART B-REVIEWS

Characterization of Dental Epithelial Stem Cells from the Mouse Incisor with Two-Dimensional and Three-Dimensional Platforms

(2012) Miquella G. Chavez et al.   TISSUE ENGINEERING PART C-METHODS

Hierarchical nanoengineered surfaces for enhanced cytoadhesion and drug delivery

(2011) Kathleen E. Fischer et al.   BIOMATERIALS

The effect of substrate microtopography on focal adhesion maturation and actin organization via the RhoA/ROCK pathway

(2011) Chang Ho Seo et al.   BIOMATERIALS

Elasticity boundary conditions required for cell mechanotaxis on microelastically-patterned gels

(2011) Takahito Kawano et al.   BIOMATERIALS

Characteristics of motility-based filtering of adherent cells on microgrooved surfaces

(2011) Hiromi Miyoshi et al.   BIOMATERIALS

The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche

(2011) Hironobu Fujiwara et al.   CELL

Structure and function of focal adhesions

(2011) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

3D inverted colloidal crystals in realistic cell migration assays for drug screening applications

(2011) Joakim da Silva et al.   Integrative Biology

Imaging molecular dynamics in vivo – from cell biology to animal models

(2011) Paul Timpson et al.   JOURNAL OF CELL SCIENCE

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule Level

(2011) Mark Schvartzman et al.   NANO LETTERS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration

(2011) Katarina Wolf et al.   TRENDS IN CELL BIOLOGY

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Direct differentiation of human embryonic stem cells into selective neurons on nanoscale ridge/groove pattern arrays

(2010) Man Ryul Lee et al.   BIOMATERIALS

The cytoskeletal organization of breast carcinoma and fibroblast cells inside three dimensional (3-D) isotropic silicon microstructures

(2010) Mehdi Nikkhah et al.   BIOMATERIALS

Control of highly migratory cells by microstructured surface based on transient change in cell behavior

(2010) Hiromi Miyoshi et al.   BIOMATERIALS

Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells

(2010) Masatoshi Ohgushi et al.   Cell Stem Cell

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: Involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways

(2010) Min Hee Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different sensitivity of human endothelial cells, smooth muscle cells and fibroblasts to topography in the nano–micro range

(2009) Sarah A. Biela et al.   Acta Biomaterialia

Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy

(2009) Deok-Ho Kim et al.   ADVANCED FUNCTIONAL MATERIALS

Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function

(2009) Christopher J. Bettinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Correlation of anisotropic cell behaviors with topographic aspect ratio

(2009) Adam S. Crouch et al.   BIOMATERIALS

The use of combinatorial topographical libraries for the screening of enhanced osteogenic expression and mineralization

(2009) Jette Lovmand et al.   BIOMATERIALS

Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients

(2009) Deok-Ho Kim et al.   BIOMATERIALS

The cavity-to-cavity migration of leukaemic cells through 3D honey-combed hydrogels with adjustable internal dimension and stiffness

(2009) Joakim da Silva et al.   BIOMATERIALS

The regulation of tendon stem cell differentiation by the alignment of nanofibers

(2009) Zi Yin et al.   BIOMATERIALS

Substrate Topography Induces a Crossover from 2D to 3D Behavior in Fibroblast Migration

(2009) Marion Ghibaudo et al.   BIOPHYSICAL JOURNAL

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Biology and Physics of Cell Shape Changes in Development

(2009) Ewa Paluch et al.   CURRENT BIOLOGY

Cytoskeletal control of growth and cell fate switching

(2009) Akiko Mammoto et al.   CURRENT OPINION IN CELL BIOLOGY

Actomyosin contractility spatiotemporally regulates actin network dynamics in migrating cells

(2009) Kennedy Omondi Okeyo et al.   JOURNAL OF BIOMECHANICS

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Mechanically induced osteogenic differentiation - the role of RhoA, ROCKII and cytoskeletal dynamics

(2009) E. J. Arnsdorf et al.   JOURNAL OF CELL SCIENCE

Three-Dimensional Polycaprolactone Hierarchical Scaffolds Supplemented with Natural Biomaterials to Enhance Mesenchymal Stem Cell Proliferation

(2009) Hyeon Yoon et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Directing cell motions on micropatterned ratchets

(2009) Goher Mahmud et al.   Nature Physics

Cytoskeleton-based forecasting of stem cell lineage fates

(2009) M. D. Treiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Collagen-based cell migration models in vitro and in vivo

(2009) Katarina Wolf et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Substrate topography shapes cell function

(2009) Karina Kulangara et al.   Soft Matter

Enhancing Osteogenic Differentiation of Mouse Embryonic Stem Cells by Nanofibers

(2009) Laura A. Smith et al.   TISSUE ENGINEERING PART A

Characterization of Endothelial Basement Membrane Nanotopography in Rhesus Macaque as a Guide for Vessel Tissue Engineering

(2009) Sara J. Liliensiek et al.   TISSUE ENGINEERING PART A

3D polycarprolactone (PCL) scaffold with hierarchical structure fabricated by a piezoelectric transducer (PZT)-assisted bioplotter

(2008) Geun Hyung Kim et al.   APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING

The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system

(2008) Shelly R. Peyton et al.   BIOMATERIALS

The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation

(2008) Lily Peng et al.   BIOMATERIALS

The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages

(2008) Jingwei Xie et al.   BIOMATERIALS

Attachment and response of human fibroblast and breast cancer cells to three dimensional silicon microstructures of different geometries

(2008) Mehdi Nikkhah et al.   BIOMEDICAL MICRODEVICES

Cytoskeletal role in differential adhesion patterns of normal fibroblasts and breast cancer cells inside silicon microenvironments

(2008) Mehdi Nikkhah et al.   BIOMEDICAL MICRODEVICES

The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF

(2008) S. Pearson et al.   DEVELOPMENT

Mechanotransduction - a field pulling together?

(2008) C. S. Chen   JOURNAL OF CELL SCIENCE

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Growth control by intracellular tension and extracellular stiffness

(2008) Richard K. Assoian et al.   TRENDS IN CELL BIOLOGY

Enhancement of In Vitro Capillary Tube Formation by Substrate Nanotopography

(2007) C. J. Bettinger et al.   ADVANCED MATERIALS

The response of fibroblasts to hexagonal nanotopography fabricated by electron beam lithography

(2007) Matthew J. Dalby et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A