Mechanobiology: a new frontier for human pluripotent stem cells

Glycosaminoglycan-Binding Hydrogels Enable Mechanical Control of Human Pluripotent Stem Cell Self-Renewal

(2012) Samira Musah et al.   ACS Nano

Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation

(2012) Amar M. Singh et al.   Cell Stem Cell

Matrix-bound heparan sulfate is essential for the growth and pluripotency of human embryonic stem cells

(2012) Mariana P Stelling et al.   GLYCOBIOLOGY

Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells

(2012) Albert J. Keung et al.   Integrative Biology

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Mechanics Regulates Fate Decisions of Human Embryonic Stem Cells

(2012) Yubing Sun et al.   PLoS One

Role of E-cadherin and other cell adhesion molecules in survival and differentiation of human pluripotent stem cells

(2012) Li Li et al.   Cell Adhesion & Migration

The influence of scaffold elasticity on germ layer specification of human embryonic stem cells

(2011) Janet Zoldan et al.   BIOMATERIALS

Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin

(2011) Andrew L. Smith et al.   MOLECULAR BIOLOGY OF THE CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Three-dimensional biomaterials for the study of human pluripotent stem cells

(2011) Thomas P Kraehenbuehl et al.   NATURE METHODS

Role of mechanical factors in fate decisions of stem cells

(2011) Dong Li et al.   Regenerative Medicine

Micro- and nanoengineering for stem cell biology: the promise with a caution

(2011) Kshitiz et al.   TRENDS IN BIOTECHNOLOGY

Chemical Control of Stem Cell Fate and Developmental Potential

(2010) Costas A. Lyssiotis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

(2010) Guokai Chen et al.   Cell Stem Cell

Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells

(2010) Masatoshi Ohgushi et al.   Cell Stem Cell

Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling

(2010) Nadja Jastrebova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions

(2010) Dong Li et al.   JOURNAL OF CELL BIOLOGY

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells

(2010) Jeff Holst et al.   NATURE BIOTECHNOLOGY

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

(2010) Sergey Rodin et al.   NATURE BIOTECHNOLOGY

Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells

(2010) Ying Mei et al.   NATURE MATERIALS

A defined glycosaminoglycan-binding substratum for human pluripotent stem cells

(2010) Joseph R Klim et al.   NATURE METHODS

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

(2010) Farhan Chowdhury et al.   PLoS One

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair

(2010) Tao-Sheng Li et al.   STEM CELLS

Microengineered Platforms for Cell Mechanobiology

(2009) Deok-Ho Kim et al.   Annual Review of Biomedical Engineering

Minireview: A Tiny Touch: Activation of Cell Signaling Pathways with Magnetic Nanoparticles

(2009) Nathan J. Sniadecki   ENDOCRINOLOGY

Characterization of integrin engagement during defined human embryonic stem cell culture

(2009) Ying Meng et al.   FASEB JOURNAL

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Roles of Integrins in Human Induced Pluripotent Stem Cell Growth on Matrigel and Vitronectin

(2009) Teisha J. Rowland et al.   STEM CELLS AND DEVELOPMENT

TGFβ/Activin/Nodal Pathway in Inhibition of Human Embryonic Stem Cell Differentiation by Mechanical Strain

(2008) Somen Saha et al.   BIOPHYSICAL JOURNAL

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Rho-Rock-Myosin Signaling Axis Determines Cell-Cell Integrity of Self-Renewing Pluripotent Stem Cells

(2008) Nicole Harb et al.   PLoS One

Recombinant Vitronectin Is a Functionally Defined Substrate That Supports Human Embryonic Stem Cell Self-Renewal via αVβ5 Integrin

(2008) Stefan R. Braam et al.   STEM CELLS