Article
Cell Biology
Leigh Goedeke, Kelsey N. Murt, Andrea Di Francesco, Joao Paulo Camporez, Ali R. Nasiri, Yongliang Wang, Xian-Man Zhang, Gary W. Cline, Rafael de Cabo, Gerald Shulman
Summary: Mild mitochondrial uncoupling has potential as an anti-aging therapy, but chronic ingestion of uncouplers has unwanted side effects. A controlled-release mitochondrial protonophore (CRMP) was developed and tested in aged high-fat diet-fed mice. The results showed that CRMP reduced hepatic lipid content, improved insulin resistance, and protected against neoplastic disorders, demonstrating the potential of liver-directed mitochondrial uncouplers in promoting healthy aging.
Article
Endocrinology & Metabolism
Hiroki Ishikawa, Ryuichi Nagashima, Yoshihiro Kuno, Hiraku Sasaki, Chikara Kohda, Masayuki Iyoda
Summary: This study investigated the role of NKT cells in diseases caused by high-fat diet. The results showed that mice lacking NKT cells were more susceptible to HFD-induced obesity, but had a weaker response to serum biochemical markers abnormalities.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Qishun Zhou, Fangrong Zhang, Jakob Kerbl-Knapp, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujic, Alena Akhmetshina, Gerd Hoerl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl
Summary: This study investigates the impact of PEMT on aging-associated energy metabolism using metabolomics. The results show that the effect of PEMT knockout is tissue-specific and age-dependent. Additionally, the absence of PEMT increases the divergence of the metabolome during aging in the liver, adipose tissues, and intestines.
Article
Biochemistry & Molecular Biology
Ardijana Novaj, Matthew G. Engel, Ruixuan Wang, Kai Mao, Xiaonan Xue, Yam Amir, Gil Atzmon, Derek M. Huffman
Summary: There is growing evidence that aging and its associated diseases can be delayed by targeted pharmacologic and dietary interventions. Identifying dietary strategies involving the incorporation of whole foods that can protect against aging is also important. Recent studies have suggested that nut consumption, especially walnuts, may reduce mortality risk in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Dae Seong Yoon, Su Yeon Cho, Hye Jin Yoon, Sang Ryong Kim, Un Ju Jung
Summary: The study found that PC can reduce white adipose tissue weight, adipocyte size, and plasma leptin levels in mice, along with decreased lipogenic enzyme activity and mRNA expression in adipose tissue. Additionally, PC can lower hepatic lipogenic enzyme activity and gene expression while increasing fatty acid oxidation and gene expression in the liver.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lingli Cai, Xinyi Xia, Yunjie Gu, Lili Hu, Cheng Li, Xiaojing Ma, Jun Yin
Summary: Low-carbohydrate diet (LCD) is effective for weight loss and improved glycemic control in humans, but in mice, high-fat diets (HFD) are more attractive and can lead to obesity and metabolic disorders. Different food preferences may be the underlying mechanism behind the opposite effects of LCD/HFD in humans and mice.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Patricia Perez-Matute, Iciar P. Lopez, Maria iniguez, Emma Recio-Fernandez, Raquel Torrens, Sergio Pineiro-Hermida, Elvira Alfaro-Arnedo, Luong Chau, Christina Walz, Andreas Hoeflich, Jose A. Oteo, Jose G. Pichel
Summary: This study aims to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice. The results showed that young IGF1R-deficient mice were insulin-resistant and had altered circulating levels of IGF1, growth hormone (GH), and IGFBP3. Middle-aged IGF1R-deficient male mice were able to counteract the negative effects induced by aging and high-fat diet (HFD) in adiposity, inflammation, and glucose metabolism, demonstrating a metabolic sexual dimorphism dependent on IGF1R.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Chengxiang Hu, Rong Huang, Runhong Li, Ning Ning, Yue He, Jiaqi Zhang, Yingxin Wang, Yanan Ma, Lina Jin
Summary: This study found that healthy low-carbohydrate diet (LCD) and low-fat diet (LFD) can protect against metabolic-dysfunction-associated fatty liver disease (MAFLD), while unhealthy LFD can increase the risk of MAFLD. Both the quantity and quality of macronutrients have significant influences on MAFLD.
Review
Nutrition & Dietetics
Anouk E. M. Willems, Martina Sura-de Jong, Andre P. van Beek, Esther Nederhof, Gertjan van Dijk
Summary: The study found that both low-carbohydrate and low-fat diets can lead to weight loss and improve markers of MetS. Weight loss is the most effective way to reduce fasting glucose levels, while actual intake of carbohydrates and fats can improve blood pressure and triglyceride levels.
Article
Anatomy & Morphology
Alejandra Freire-Regatillo, Sonia Diaz-Pacheco, Laura M. Frago, Maria-Angeles Arevalo, Jesus Argente, Luis M. Garcia-Segura, Maria L. de Ceballos, Julie A. Chowen
Summary: The propensity to develop neurodegenerative diseases is influenced by various factors, including genetic background, sex, lifestyle, and age. High fat diet (HFD) leads to obesity and neurodegeneration, and there are sex differences in the response to HFD, with females showing greater weight gain and fat accumulation.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Medicine, General & Internal
Yimin Zhao, Yueying Li, Wenxiu Wang, Zimin Song, Zhenhuang Zhuang, Duo Li, Lu Qi, Tao Huang
Summary: This study aimed to investigate the long-term associations between low-carbohydrate diets (LCDs) and low-fat diets (LFDs) and mortality among middle-aged and older individuals. The results showed that higher scores of overall LCD and unhealthy LCD were associated with increased risks of total and cause-specific mortality, while a healthy LCD was associated with slightly lower total mortality. On the other hand, the highest score of a healthy LFD was associated with significantly lower total, cardiovascular, and cancer mortality. These findings highlight the importance of maintaining a healthy LFD with less saturated fat in preventing all-cause and cause-specific mortality among middle-aged and older individuals.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Hepatocyte-specific loss of ANGPTL4 does not improve triglyceride phenotypes during high-fat feeding, but these mice show improved glucose tolerance after chronic high-fat diet. Additionally, Angptl4(LivKO) mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Mon-Chien Lee, Yi-Ju Hsu, Hsin-Ching Sung, Ya-Ting Wen, Li Wei, Chi-Chang Huang
Summary: Women during pregnancy and the postpartum period, especially those with excessive caloric intake, have a higher risk of obesity and metabolic diseases. This study found that mice with low-fitness phenotype were more likely to develop metabolic abnormalities and obesity after dietary induction following delivery, while mice with high-fitness phenotype had a protective mechanism.
Article
Biochemistry & Molecular Biology
Jae-Kwon Jo, Seung-Ho Seo, Seong-Eun Park, Hyun-Woo Kim, Eun-Ju Kim, Jeong-Sang Kim, Ju-Yeon Pyo, Kwang-Moon Cho, Sun-Jae Kwon, Dae-Hun Park, Hong-Seok Son
Summary: This study aimed to identify gut microbiota-metabolomic signatures altered by a high-fat diet, revealing a significant increase in specific Firmicutes in the HFD group correlated with certain metabolites levels, impacting various metabolic pathways.
Article
Multidisciplinary Sciences
Santiago Guerra-Cantera, Laura M. M. Frago, Maria Jimenez-Hernaiz, Roberto Collado-Perez, Sandra Canelles, Purificacion Ros, Jorge Garcia-Piqueras, Iris Perez-Nadador, Vicente Barrios, Jesus Argente, Julie A. A. Chowen
Summary: Dietary restriction is a common weight loss strategy, but returning to poor dietary habits can result in more weight gain. The effects of weight loss from a healthy diet on the response to resumption of poor dietary habits are not well studied. The involvement of the sex-dependent IGF system in this response is also unknown.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hye Suk Kang, Mi-Young Kim, Seung-Jae Kim, Jae-Ho Lee, Yong-Deuk Kim, Young-Kyo Seo, Jae-Hoon Bae, Goo-Taeg Oh, Dae-Kyu Song, Yong-Ho Ahn, Seung-Soon Im
BIOCHEMICAL JOURNAL
(2015)
Editorial Material
Endocrinology & Metabolism
Mi-Young Kim, Yong-Ho Ahn
Article
Multidisciplinary Sciences
Joo-Man Park, Tae-Hyun Kim, Seong-Ho Jo, Mi-Young Kim, Yong-Ho Ahn
SCIENTIFIC REPORTS
(2015)
Review
Cell Biology
Joo-Man Park, Seong-Ho Jo, Mi-Young Kim, Tae-Hyun Kim, Yong-Ho Ahn
Article
Biochemistry & Molecular Biology
Joo-Man Park, Tae-Hyun Kim, Jin-Sik Bae, Mi-Young Kim, Kyung-Sup Kim, Yong-Ho Ahn
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2010)
Article
Endocrinology & Metabolism
M. Y. Kim, S. H. Jo, J. M. Park, T. H. Kim, S. S. Im, Y. H. Ahn
Article
Endocrinology & Metabolism
Seong Ho Jo, Mi Young Kim, Joo Man Park, Tae Hyun Kim, Yong Ho Ahn
Review
Endocrinology & Metabolism
Mi-Young Kim, Jin-Sik Bae, Tae-Hyun Kim, Joo-Man Park, Yong Ho Ahn
EXPERIMENTAL DIABETES RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Seung-Soon Im, Mi-Young Kim, Sool-Ki Kwon, Tae-Hyun Kim, Jin-Sik Bae, Hail Kim, Kyung-Sup Kim, Goo-Taeg Oh, Yong-Ho Ahn
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Multidisciplinary Sciences
Yun-Seung Jeong, Deokhoon Kim, Yong Seok Lee, Ha-Jung Kim, Jung-Youn Han, Seung-Soon Im, Hansook Kim Chong, Je-Keun Kwon, Yun-Ho Cho, Woo Kyung Kim, Timothy F. Osborne, Jay D. Horton, Hee-Sook Jun, Yong-Ho Ahn, Sung-Min Ahn, Ji-Young Cha
Review
Chemistry, Analytical
Jin-Sik Bae, Tae-Hyun Kim, Mi-Young Kim, Joo-Man Park, Yong-Ho Ahn
Review
Medicine, General & Internal
Tae-Hyun Kim, Mi-Young Kim, Seong-Ho Jo, Joo-Man Park, Yong-Ho Ahn
YONSEI MEDICAL JOURNAL
(2013)
Article
Cell Biology
T-H Kim, S-H Jo, H. Choi, J-M Park, M-Y Kim, H. Nojima, J-W Kim, Y-H Ahn
CELL DEATH & DISEASE
(2014)
Review
Endocrinology & Metabolism
Yong Ho Ahn
DIABETES & METABOLISM JOURNAL
(2018)